دورية أكاديمية
Evidence of a hypercoagulable state in patients with acute lymphoblastic leukemia treated with low dose of E. coli L-asparaginase: a GIMEMA study.
| العنوان: | Evidence of a hypercoagulable state in patients with acute lymphoblastic leukemia treated with low dose of E. coli L-asparaginase: a GIMEMA study. |
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| المؤلفون: | G. Leone, L. Gugliotta, M. G. Mazzucconi, V. D. Stefano, M. M. Belmonte, F. Dragoni, G. Specchia, A. Centra, G. Gamba, A. Camera, F. Mandelli, P. Leoni, M. Montillo, E. Volpe, N. Cantore, S. V. Zagonel, A. Pinto, V. Liso, S. Tura, G. Visani, G. Broccia, W. Deplano, E. Cacciola, G. Milone, A. Alberti, A. Peta, E. Bianchini, A. Porcellini, F. Leoni, S. Ciolli, L. Deriu, F. Decataldo, F. Baudo, A. Spada, R. Debiase, E. Miraglia, B. Rotoli, A. Gabbas, G. Latte, F. Caronia, S. Vasta, P. Citarrella, M. T. Reyes, M. Martelli, A. Tabilio, G. Lucarelli, G. Sparaventi, G. Torlontano, G. Recchia, F. Ricciuti, A. Dinota, F. Nobile, L. Annino, A. Ferrari, A. Delaurenzi, N. Petti, G. Papa, E. Stipa, M. Carotenuto, S. Ladogana, M. Baccarani, G. Fasola, ASCARI, EDOARDO, INVERNIZZI, ROSANGELA |
| المساهمون: | G., Leone, L., Gugliotta, M. G., Mazzucconi, V. D., Stefano, M. M., Belmonte, F., Dragoni, G., Specchia, A., Centra, G., Gamba, A., Camera, F., Mandelli, P., Leoni, M., Montillo, E., Volpe, N., Cantore, S. V., Zagonel, A., Pinto, V., Liso, S., Tura, G., Visani, G., Broccia, W., Deplano, E., Cacciola, G., Milone, A., Alberti, A., Peta, E., Bianchini, A., Porcellini, F., Leoni, S., Ciolli, L., Deriu, F., Decataldo, F., Baudo, A., Spada, R., Debiase, E., Miraglia, B., Rotoli, A., Gabba, G., Latte, F., Caronia, S., Vasta, P., Citarrella, M. T., Reye, Ascari, Edoardo, Invernizzi, Rosangela, M., Martelli, A., Tabilio, G., Lucarelli, G., Sparaventi, G., Torlontano, G., Recchia, F., Ricciuti, A., Dinota, F., Nobile, L., Annino, A., Ferrari, A., Delaurenzi, N., Petti, G., Papa, E., Stipa, M., Carotenuto, S., Ladogana, M., Baccarani, G., Fasola |
| سنة النشر: | 1993 |
| المجموعة: | IRIS UNIPV (Università degli studi di Pavia) |
| مصطلحات موضوعية: | Asparaginase, Acute lymphoblastic leukemia, Therapy, Blood coagulation factors |
| الوصف: | Blood coagulation abnormalities induced by administration of E. coli L-asparaginase were investigated in 25 patients with acute lymphoblastic leukemia treated according to the GIMEMA ALL 0288 trial. Dosage of L-asparaginase was relatively low (6,000 U/m2/day for 7 days total dose 42,000 U/m2) as compared to the conventional dosages (120,000-140,000 U/m2 over 10-14 days). A significant decrease in fibronogen, plasminogen, alpha2-antiplasmin and antithrombin III was observed from day IV of L-asparaginase and it was maximum on day VIII, with return to the baseline levels on day XV. Protein C levels had only a borderline reduction, while no modification of protein S or factor VII was observed. Two of the patients investigated developed thrombosis. The presence of a prothrombotic state induced even by this low dosage of E. coli L-asparaginase was suggested by a significant increase of sensitive markers of hypercoagulability such as fibrinopeptide A, thrombin-antithrombin complexes, and prothrombin fragment F1 + 2. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/8446931; info:eu-repo/semantics/altIdentifier/wos/WOS:A1993KH65500004; volume:69; issue:1; firstpage:12; lastpage:15; numberofpages:3; journal:THROMBOSIS AND HAEMOSTASIS; http://hdl.handle.net/11571/559844Test |
| الإتاحة: | http://hdl.handle.net/11571/559844Test |
| رقم الانضمام: | edsbas.F99F8229 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |