Second‐ and third‐trimester serum levels of growth‐differentiation factor‐15 in prediction of pre‐eclampsia
| العنوان: | Second‐ and third‐trimester serum levels of growth‐differentiation factor‐15 in prediction of pre‐eclampsia |
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| المؤلفون: | Argyro Syngelaki, F. da Silva Costa, Daniel L. Rolnik, Guiying Nie, D Wertaschnigg, S. S. Y. Teoh, K. H. Nicolaides |
| المصدر: | Ultrasound in Obstetrics & Gynecology. 56:879-884 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Growth Differentiation Factor 15, Pregnancy Trimester, Third, Gestational Age, Third trimester, Asymptomatic, 03 medical and health sciences, 0302 clinical medicine, Pre-Eclampsia, Predictive Value of Tests, Pregnancy, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Prospective Studies, 030212 general & internal medicine, 030219 obstetrics & reproductive medicine, Eclampsia, Radiological and Ultrasound Technology, business.industry, Obstetrics, Obstetrics and Gynecology, Gestational age, General Medicine, medicine.disease, Reproductive Medicine, Case-Control Studies, Pregnancy Trimester, Second, embryonic structures, Gestation, Biomarker (medicine), Female, GDF15, medicine.symptom, business, Biomarkers, Maternal Serum Screening Tests, Blood sampling |
| الوصف: | Objective: Pre-eclampsia (PE) is a significant contributor to adverse maternal and perinatal outcome; however, accurate prediction and early diagnosis of this condition remain a challenge. The aim of this study was to compare serum levels of growth-differentiation factor-15 (GDF-15) at three different gestational ages between asymptomatic women who subsequently developed preterm or term PE and healthy controls. Methods: This was a case–control study drawn from a prospective observational study on adverse pregnancy outcomes in women attending for their routine second- and third-trimester hospital visits. Serum GDF-15 was determined in 300 samples using a commercial GDF-15 enzyme-linked immunosorbent assay: 120 samples at 19–24 weeks of gestation, 120 samples at 30–34 weeks and 60 samples at 35–37 weeks. Multiple linear regression was applied to logarithmically transformed GDF-15 control values to evaluate the influence of gestational age at blood sampling and maternal characteristics on GDF-15 results. GDF-15 multiples of the normal median (MoM) values, adjusted for gestational age and maternal characteristics, were compared between pregnancies that subsequently developed preterm or term PE and healthy controls. Results: Values of GDF-15 increased with gestational age. There were no significant differences in GDF-15 MoM values between cases of preterm or term PE and normotensive pregnancies at 19–24 or 35–37 weeks of gestation. At 30–34 weeks, GDF-15 MoM values were significantly increased in cases of preterm PE, but not in those who later developed term PE. Elevated GDF-15 MoM values were associated significantly with a shorter interval between sampling at 30–34 weeks and delivery with PE (P = 0.005). Conclusion: Serum GDF-15 levels at 19–24 or 35–37 weeks of gestation are not predictive of preterm or term PE. At 30–34 weeks, GDF-15 levels are higher in women who subsequently develop preterm PE; however, this difference is small and GDF-15 is unlikely to be useful in clinical practice when used in isolation. Copyright © 2020 ISUOG. Published by John Wiley & Sons Ltd. |
| تدمد: | 1469-0705 0960-7692 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31555ddac9dd51a50f12cbdc9e6cd10Test https://doi.org/10.1002/uog.22070Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e31555ddac9dd51a50f12cbdc9e6cd10 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14690705 09607692 |
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