المؤلفون: Happonen, Natalie, Harma, Mari-Anne, Akhi, Ramin, Nissinen, Antti E., Savolainen, Markku J., Ruuth, Maija, Öörni, Katariina, Adeshara, Krishna, Lehto, Markku, Groop, Per-Henrik, Koivukangas, Vesa, Hukkanen, Janne, Hörkkö, Sohvi

المساهمون: CAMM - Research Program for Clinical and Molecular Metabolism, Helsinki University Hospital Area, Molecular and Integrative Biosciences Research Programme, Nefrologian yksikkö, Medicum, Clinicum, HUS Abdominal Center, Research Programs Unit, Department of Medicine, Per Henrik Groop / Principal Investigator

مصطلحات موضوعية: Roux-en-Y gastric bypass surgery, Immunoglobulins, Natural antibodies, Obesity, 11832 Microbiology and virology

وصف الملف: application/pdf

العلاقة: N.H. wrote the first draft of the manuscript, and performed statistical analyses and part of the experimental work. J.H., M.J.S., V.K., and S.H. contributed to the conception of the idea, design of the study, and critically evaluated the manuscript. R.A., A.E.N., M-A.H., K.A., M.R., and K.O. were involved with the experimental work and critically evaluated the manuscript. M.L. and P.-H.G. participated in the interpretation of the results and critically evaluated the manuscript. All authors approved the final content of the manuscript. The Yrjo Jahnsson Foundation (20197174), Academy of Finland (275614, 316664, and 315568), Novo Nordisk Foundation (#NNF OC0013659), Signe and Ane Gyllenberg Foundation, Folkhalsan Research Foundation, Helsinki University Central Hospital Research Funds, the Diabetes Research Foundation, the Paivikki and Sakari Sohlberg Foundation, the Finnish Foundation for Cardiovascular Research, the Northern Finland Health Care Support Foundation, the Finnish Medical Foundation, Wilhelm and Else Stockmann Foundation and Nylands Nation supported this study. We thank study nurses and coordinators for their assistance in conducting the study visits.; Happonen , N , Harma , M-A , Akhi , R , Nissinen , A E , Savolainen , M J , Ruuth , M , Öörni , K , Adeshara , K , Lehto , M , Groop , P-H , Koivukangas , V , Hukkanen , J & Hörkkö , S 2023 , ' Impact of RYGB surgery on plasma immunoglobulins : association between blood pressure and glucose levels six months after surgery ' , APMIS . https://doi.org/10.1111/apm.13366Test; ORCID: /0000-0001-8903-0617/work/151223208; ORCID: /0000-0002-9525-0250/work/151226138; 815f56d8-15e0-4939-b930-310c86cd9af9; http://hdl.handle.net/10138/569986Test; 001136187300001

الإتاحة: http://hdl.handle.net/10138/569986Test

المؤلفون: Lahelma, Mari, Qadri, Sami, Ahlholm, Noora, Porthan, Kimmo, Ruuth, Maija, Juuti, Anne, Oresic, Matej, 1967, Hyötyläinen, Tuulia, 1971, Öörni, Katariina, Yki-Järvinen, Hannele

المصدر: Atherosclerosis. 363:22-29

مصطلحات موضوعية: Atherosclerosis, Cardiovascular disease, Ceramides, Cholesterol, Lipidomics, Phosphatidylcholines, Triglycerides

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-102540Test
https://doi.org/10.1016/j.atherosclerosis.2022.11.018Test

المؤلفون: Ruuth, Maija, Lahelma, Mari, Luukkonen, Panu K., Lorey, Martina B., Qadri, Sami, Sädevirta, Sanja, Hyötyläinen, Tuulia, 1971, Kovanen, Petri T., Hodson, Leanne, Yki-Järvinen, Hannele, Öörni, Katariina

المصدر: Arteriosclerosis, Thrombosis and Vascular Biology. 41(11):2823-2836

مصطلحات موضوعية: Atherosclerosis, low-density lipoprotein, mitral valve, nutrition, sphingomyelin

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-94085Test
https://doi.org/10.1161/ATVBAHA.120.315766Test

المؤلفون: Lahelma, Mari, Qadri, Sami, Ahlholm, Noora, Porthan, Kimmo, Ruuth, Maija, Juuti, Anne, Orešič, Matej, Hyötyläinen, Tuulia, Öörni, Katariina, Yki-Järvinen, Hannele

المساهمون: Department of Medicine, HUS Internal Medicine and Rehabilitation, Clinicum, Medicum, HUS Abdominal Center, Molecular and Integrative Biosciences Research Programme, Biosciences, Hannele Yki-Järvinen Research Group

مصطلحات موضوعية: 3121 General medicine, internal medicine and other clinical medicine, Ateroskleroosi, Maksasairaudet, Lipoproteiinit, Lihavuus, Sfingolipidit, NAFLD, ei-alkoholiperäinen rasvamaksatauti, rasvamaksatauti, rasvamaksa, LDL, aggregaatio, lipidomiikka, maksabiopsia, keramidit, Atherosclerosis, Liver Diseases, Lipoproteins, Obesity, Sphingolipids, non-alcoholic fatty liver disease, fatty liver disease, fatty liver, aggregation, lipidomics, liver biopsy, ceramides

وصف الملف: application/pdf

العلاقة: We would like to acknowledge the technical assistance of Maija Atuegwu, and Aila Karioja-Kallio and Päivi Ihamuotila for their excellent assistance with the clinical studies.; Lahelma , M , Qadri , S , Ahlholm , N , Porthan , K , Ruuth , M , Juuti , A , Orešič , M , Hyötyläinen , T , Öörni , K & Yki-Järvinen , H 2022 , ' The human liver lipidome is significantly related to the lipid composition and aggregation susceptibility of low-density lipoprotein (LDL) particles ' , Atherosclerosis , vol. 363 , pp. 22-29 . https://doi.org/10.1016/j.atherosclerosis.2022.11.018Test; ORCID: /0000-0002-9525-0250/work/127508902; ORCID: /0000-0001-8903-0617/work/127509600; ORCID: /0000-0001-9313-9324/work/127510030; 85142845412; 97135a32-a83a-4bf8-a1fa-fc24df81e00c; http://hdl.handle.net/10138/353504Test; 000904447700003

الإتاحة: http://hdl.handle.net/10138/353504Test

المؤلفون: Lorey, Martina B., Youssef, Amer, Äikäs, Lauri A O, Borrelli, Matthew, Hermansson, Martin, Assini, Julia M., Kemppainen, Aapeli, Ruhanen, Hanna, Ruuth, Maija, Matikainen, Sampsa, Kovanen, Petri T., Kakela, Reijo, Boffa, Michael B., Koschinsky, Marlys L., Öörni, Katariina

المساهمون: Molecular and Integrative Biosciences Research Programme, Functional Lipidomics Group, HUS Internal Medicine and Rehabilitation, Helsinki Institute of Life Science HiLIFE

مصطلحات موضوعية: Apolipoproteins, Atherosclerosis, Atherosclerotic cardiovascular disease, Caspase-1, Inflammation, Interleukin-1 family, Lipoprotein(a), 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: Lorey , M B , Youssef , A , Äikäs , L A O , Borrelli , M , Hermansson , M , Assini , J M , Kemppainen , A , Ruhanen , H , Ruuth , M , Matikainen , S , Kovanen , P T , Kakela , R , Boffa , M B , Koschinsky , M L & Öörni , K 2023 , ' Lipoprotein(a) induces caspase-1 activation and IL-1 signaling in human macrophages ' , Frontiers in cardiovascular medicine , vol. 10 , 1130162 . https://doi.org/10.3389/fcvm.2023.1130162Test; ORCID: /0000-0002-9525-0250/work/137865280; ORCID: /0000-0001-5605-6714/work/137865490; ORCID: /0000-0001-8903-0617/work/137865909; ORCID: /0000-0002-0060-5240/work/147401029; 4d86a791-fc9f-40f1-a7d0-0e636c26bb09; http://hdl.handle.net/10138/563191Test; 001002109800001

الإتاحة: http://hdl.handle.net/10138/563191Test

المؤلفون: Happonen, Natalie, Härma, Mari‐Anne, Akhi, Ramin, Nissinen, Antti E., Savolainen, Markku J., Ruuth, Maija, Öörni, Katariina, Adeshara, Krishna, Lehto, Markku, Groop, Per‐Henrik, Koivukangas, Vesa, Hukkanen, Janne, Hörkkö, Sohvi

المساهمون: Academy of Finland, Diabetestutkimussäätiö, Folkhälsanin Tutkimussäätiö, Novo Nordisk Fonden, Päivikki ja Sakari Sohlbergin Säätiö, Pohjois-Suomen Terveydenhuollon Tukisäätiö, Signe ja Ane Gyllenbergin Säätiö, Sydäntutkimussäätiö, Yrjö Jahnssonin Säätiö, Wilhelm och Else Stockmanns stiftelse

المصدر: APMIS ; volume 132, issue 3, page 187-197 ; ISSN 0903-4641 1600-0463

الإتاحة: https://doi.org/10.1111/apm.13366Test

المؤلفون: Erkkilä, Arja T., Manninen, Suvi, Fredrikson, Linda, Bhalke, Monika, Holopainen, Minna, Ruuth, Maija, Lankinen, Maria, Käkelä, Reijo, Öörni, Katariina, Schwab, Ursula S.

المساهمون: Helsinki Institute of Life Science HiLIFE, Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, Functional Lipidomics Group, Medicum, Research Programs Unit

مصطلحات موضوعية: Aggregation, Alpha-linolenic acid, Fish, Low-density lipoprotein, Lipidomics, n-3 PUFA, LOW-DENSITY-LIPOPROTEIN, QUANTITATIVE-ANALYSIS, PARTICLES, SUPPLEMENTATION, ELECTROSPRAY, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

العلاقة: Suomen Kasvioljyt Ltd., Kesko Ltd., and Bunge Fin-land Ltd. provided oil and fat spreads. This study was fi-nancially supported by Finnish Diabetes Research Founda-tion; Competitive Research Funding of the Northern Savo Hospital District special state subsidy for health research; Juho Vainio Foundation; the Central Foundation and the North Savo Regional Fund of the Finnish Cultural Founda-tion; Paavo Nurmi Foundation; and Yrjo Jahnsson Founda-tion (grant number 6437); Finnish Foundation for Cardio-vascular Research; the Academy of Finland (grant numbers 315568 and 332564) and Novo Nordisk Fonden.; Erkkilä , A T , Manninen , S , Fredrikson , L , Bhalke , M , Holopainen , M , Ruuth , M , Lankinen , M , Käkelä , R , Öörni , K & Schwab , U S 2021 , ' Lipidomic changes of LDL after consumption of Camelina sativa oil, fatty fish and lean fish in subjects with impaired glucose metabolism-A randomized controlled trial ' , Journal of Clinical Lipidology , vol. 15 , no. 5 , pp. 743-751 . https://doi.org/10.1016/j.jacl.2021.08.060Test; ORCID: /0000-0002-3030-8677/work/105911447; ORCID: /0000-0002-9525-0250/work/105911608; ORCID: /0000-0001-8903-0617/work/105911743; http://hdl.handle.net/10138/338338Test; 0adc40c2-a102-4f95-aca4-7f270b234c4c; 000731791700017

الإتاحة: http://hdl.handle.net/10138/338338Test

المؤلفون: Heffron, Sean P., Ruuth, Maija K., Xia, Yuhe, Hernandez, Gustavo, Äikäs, Lauri, Rodriguez, Crystalann, Öörni, Katariina, Berger, Jeffrey S.

المساهمون: Medicum, CAN-PRO - Translational Cancer Medicine Program, Faculty of Medicine, Research Programs Unit, Molecular and Integrative Biosciences Research Programme, Biosciences, Faculty of Biological and Environmental Sciences, University of Helsinki

مصطلحات موضوعية: Peripheral artery disease, Low-density lipoprotein, Major adverse cardiovascular events, Risk, GREATER FREQUENCY, LOWER PREVALENCE, SUSCEPTIBILITY, CONSUMPTION, POPULATION, PARTICLES, 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: SPH was supported by NIH (HL135398). KO was supported by The Academy of Finland (#315568), the Finnish Foundation for Cardiovascular Research, and Aarne Koskelo Foundation. JSB was supported by NIH (HL139909 and HL144993).; Heffron , S P , Ruuth , M K , Xia , Y , Hernandez , G , Äikäs , L , Rodriguez , C , Öörni , K & Berger , J S 2021 , ' Low-density lipoprotein aggregation predicts adverse cardiovascular events in peripheral artery disease ' , Atherosclerosis , vol. 316 , pp. 53-57 . https://doi.org/10.1016/j.atherosclerosis.2020.11.016Test; ORCID: /0000-0002-9525-0250/work/87788799; ORCID: /0000-0001-8903-0617/work/87789027; ORCID: /0000-0002-0060-5240/work/137046033; 3c1d21f6-c66b-49e8-845c-bc0d0a734109; http://hdl.handle.net/10138/340117Test; 000604560000008

الإتاحة: http://hdl.handle.net/10138/340117Test

المؤلفون: Christensen, Jacob J., Narverud, Ingunn, Ruuth, Maija, Heier, Martin, Jauhiainen, Matti, Ulven, Stine M., Bogsrud, Martin P., Kovanen, Petri T., Halvorsen, Bente, Oda, Michael N., Wium, Cecilie, Retterstøl, Kjetil, Öörni, Katariina, Holven, Kirsten B.

المساهمون: Research Programs Unit, University of Helsinki, Medicum, Molecular and Integrative Biosciences Research Programme, Biosciences

مصطلحات موضوعية: ASCVD, children, cholesterol, familial hypercholesterolemia, HDL-apoA-I exchange, LDL aggregation, lipoproteins, metabolomics, NMR, reverse cholesterol transport, 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: We would like to thank all children and families that kindly chose to participate in our research studies. We would also like to thank technician Maija Atuegwu for helpful assistance with laboratory analyses. This work was funded by the University of Oslo (Oslo, Norway), the National Advisory Unit on FH at OUH (Oslo, Norway), the Throne‐Holst Foundation for Nutrition Research (Oslo, Norway), the South‐Eastern Regional Health Authority (Oslo, Norway), the Academy of Finland(#315568 and #332564 to KÖ), the Jane and Aatos Erkko Foundation (to MJ), the Finnish Foundation for Cardiovascular Research (to MJ and KÖ), the Aarne Koskelo Foundation (to KÖ), and the Novo Nordisk Foundation (#NNF19OC0057411 to KÖ). Wihuri Research Institute is maintained by the Jenny and Antti Wihuri Foundation. Dr. Christensen has received research grants and/or personal fees from Mills DA, unrelated to the content of this manuscript. Dr. Ruuth, Kovanen and Dr. Öörni have applied for a patent on the LDL aggregation method; otherwise, they have no other relevant financial relationships to disclose. Dr. Ulven has received research grants from Tine DA, Mills DA, and Olympic Seafood, none of which are related to the content of this manuscript. Dr. Bogsrud reports personal fees from Amgen and Sanofi. Dr. Retterstøl reports personal fees from Amgen, Mills DA, The Norwegian Medical Association, The Norwegian Directorate of Health, Sanofi, Takeda, Chiesi, Bayer, MSD, and research grants from Oslo Economics and Mills outside the submitted work. Dr. Heier has received a research grant from the Norwegian Diabetes Association for analyses included in this manuscript. Dr. Holven has received research grants and/or personal fees from Tine DA, Mills DA, Olympic Seafood, Amgen, Sanofi, and Pronova, none of which are related to the content of this manuscript. The other authors have no relevant financial relationships to disclose. We would like to thank all children and families that kindly chose to participate in our research studies. We would also like to thank technician Maija Atuegwu for helpful assistance with laboratory analyses. This work was funded by the University of Oslo (Oslo, Norway), the National Advisory Unit on FH at OUH (Oslo, Norway), the Throne-Holst Foundation for Nutrition Research (Oslo, Norway), the South-Eastern Regional Health Authority (Oslo, Norway), the Academy of Finland(#315568 and #332564 to K?), the Jane and Aatos Erkko Foundation (to MJ), the Finnish Foundation for Cardiovascular Research (to MJ and K?), the Aarne Koskelo Foundation (to K?), and the Novo Nordisk Foundation (#NNF19OC0057411 to K?). Wihuri Research Institute is maintained by the Jenny and Antti Wihuri Foundation.; Christensen , J J , Narverud , I , Ruuth , M , Heier , M , Jauhiainen , M , Ulven , S M , Bogsrud , M P , Kovanen , P T , Halvorsen , B , Oda , M N , Wium , C , Retterstøl , K , Öörni , K & Holven , K B 2021 , ' Children with familial hypercholesterolemia display changes in LDL and HDL function : A cross-sectional study ' , Journal of internal medicine , vol. 290 , no. 5 , pp. 1083-1097 . https://doi.org/10.1111/joim.13383Test; ORCID: /0000-0002-9525-0250/work/102237189; ORCID: /0000-0001-8903-0617/work/102237724; 85117316392; cf2a0fb8-aa87-49f8-a256-92b25ab52073; http://hdl.handle.net/10138/351291Test; 000708677400016

الإتاحة: http://hdl.handle.net/10138/351291Test

المؤلفون: Ruuth, Maija, Äikäs, Lauri, Tigistu-Sahle, Feven, Käkelä, Reijo, Lindholm, Harri, Simonen, Piia, Kovanen, Petri T., Gylling, Helena, Öörni, Katariina

المساهمون: Medicum, Research Programs Unit, Faculty of Medicine, University of Helsinki, Molecular and Integrative Biosciences Research Programme, Functional Lipidomics Group, Physiology and Neuroscience (-2020), Department of Diagnostics and Therapeutics, Clinicum, HUS Heart and Lung Center, Kardiologian yksikkö, Helsinki University Hospital Area, Biosciences

مصطلحات موضوعية: atherosclerosis, cardiovascular disease, cholesterol, lipidomics, lipoproteins, B-CONTAINING LIPOPROTEINS, PHOSPHOLIPASE A(2), CHOLESTEROL ABSORPTION, INCREASED BINDING, APOLIPOPROTEIN-B, GROUP-V, SPHINGOMYELINASE, PARTICLES, RETENTION, 3121 General medicine, internal medicine and other clinical medicine, 1182 Biochemistry, cell and molecular biology

وصف الملف: application/pdf

العلاقة: Wihuri Research Institute is maintained by the Jenny and Antti Wihuri Foundation. This study was also supported by grants from the Academy of Finland (no. 315568), the Finnish Foundation for Cardiovascular Research to Dr Oorni, and M. Ruuth and Raisio Nutrition Ltd.; Ruuth , M , Äikäs , L , Tigistu-Sahle , F , Käkelä , R , Lindholm , H , Simonen , P , Kovanen , P T , Gylling , H & Öörni , K 2020 , ' Plant Stanol Esters Reduce LDL (Low-Density Lipoprotein) Aggregation by Altering LDL Surface Lipids The BLOOD FLOW Randomized Intervention Study ' , Arteriosclerosis, Thrombosis, and Vascular Biology , vol. 40 , no. 9 , pp. 2310-2321 . https://doi.org/10.1161/ATVBAHA.120.314329Test; ORCID: /0000-0002-9525-0250/work/80946371; ORCID: /0000-0001-8903-0617/work/80947789; ORCID: /0000-0002-0060-5240/work/137046032; 343de25b-002c-4914-a553-173d95dbadce; http://hdl.handle.net/10138/326484Test; 000567549000035

الإتاحة: http://hdl.handle.net/10138/326484Test