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Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

التفاصيل البيبلوغرافية
العنوان: Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data
المؤلفون: Thomalla, Götz, Boutitie, Florent, Cheng, Bastian, Cloud, Geoffrey, Cogez, Julien, Cortijo, Elisa, Crozier, Sophie, Damgaard, Dorte, Dani, Krishna, De Coene, Beatrijs, De Hollander, Isabel, De Keyser, Jacques, De Klippel, Nina, Churilov, Leonid, De Maeseneire, Charlotte, De Smedt, Ann, del Mar Castellanos Rodrigo, Maria, Deltour, Sandrine, Demeestere, Jelle, Derex, Laurent, Desfontaines, Philippe, Dittrich, Ralf, Dixit, Anand, Dobbels, Laurens, Ebinger, Martin, Domigo, Valérie, Dorado, Laura, Druart, Charlotte, Dupont, Kristina Hougaard, Dusart, Anne, Dziewas, Rainer, Ebner, Matthias, Edjali-Goujon, Myriam, Eisele, Philipp, Endres, Matthias, El Tawil, Salwa, Elhfnawy, Ahmed, Etexberria, Ana, Evans, Nicholas, Fandler, Simon, Fazekas, Franz, Felix, Sandra, Fiebach, Jochen B., Fiehler, Jens, Filipov, Alexandra, Fiebach, Jochen B, Filipski, Katharina, Fleischmann, Robert, Foerch, Christian, Ford, Ian, Gaenslen, Alexandra, Galinovic, Ivana, Gancedo, Elena Meseguer, Ganeshan, Ramanan, García Esperón, Carlos, Garrido, Alicia, Fukuda-Doi, Mayumi, Gattringer, Thomas, Geraghty, Olivia, Geran, Rohat, Gerloff, Christian, Gerner, Stefan, Godon-Hardy, Sylvie, Göhler, Jos, Golsari, Amir, Gomis, Meritxell, Gorriz, David, Inoue, Manabu, Gramse, Verena, Grau, Laia, Griebe, Martin, Guerrero, Cristina, Guerzoglu, Damla, Guettier, Sophie, Guiraud, Vincent, Gumbinger, Christoph, Gunreben, Ignaz, Haertig, Florian, Kleinig, Timothy J, Hametner, Christian, Hanseeuw, Bernard, Hansen, Andreas, Hansen, Jakob, Harbo, Thomas, Harloff, Andreas, Harmel, Peter, Häusler, Karl Georg, Heinen, Florian, Held, Valentin, Latour, Lawrence L, Hellwig, Simon, Hemelsoet, Dimitri, Hennerici, Michael, Herm, Juliane, Hermans, Sylvia, Hernández, María, Hervas Vicente, Jose, Hjort, Niels, Hobeanu, Cristina, Hobohm, Carsten, Lemmens, Robin, Höfner, Elmar, Hohenbichler, Katharina, Hommel, Marc, Hoppe, Julia, Hornberger, Eva, Hoyer, Carolin, Huang, Xuya, Ipsen, Nils, Isern, Irina, Ispierto, Lourdes, Ma, Henry, Levi, Christopher R, Iversen, Helle, Jeppesen, Lise, Jimenez, Marta, Jungehülsing, Jan, Jüttler, Eric, Kalladka, Dheeraj, Kallmünzer, Bernd, Kar, Arindam, Kellert, Lars, Kemmling, André, Leys, Didier, Kessler, Tobias, Khan, Usman, Klein, Matthias, Kleinschnitz, Christoph, Klockziem, Matti, Knops, Michael, Koehler, Luzie, Koehrmann, Martin, Kohlfürst, Heinz, Kollmar, Rainer, Miwa, Kaori, Kraft, Peter, Krause, Thomas, Kristensen, Bo, Kröber, Jan M., Kurka, Natalia, Ladoux, Alexandre, Laloux, Patrice, Lamy, Catherine, Landrault, Emmanuelle, Lauer, Arne, Molina, Carlos A, Lebely, Claire, Leempoel, Jonathan, Lees, Kennedy, Leger, Anne, Legrand, Laurence, Li, Lin, Löbbe, Anna-Mareike, London, Frederic, Lopez-cancio, Elena, Muir, Keith W, Lorenz, Matthias, Louw, Stephen, Lovelock, Caroline, Lozano Sánchez, Manuel, Lucente, Giuseppe, Lückl, Janos, Luna, Alain, Macha, Kosmas, Machet, Alexandre, Mackenrodt, Daniel, Nighoghossian, Norbert, Madzar, Dominik, Majoie, Charles, Männer, Anika, Maqueda, Vicky, Marstrand, Jacob, Martinez, Alicia, Marzina, Annika, Mechthouff, Laura, Meden, Per, Meersman, Guy, Parsons, Mark W, Meier, Julia, Mellerio, Charles, Menn, Oliver, Meyer, Nadja, Michalski, Dominik, Michels, Peter, Michelsen, Lene, Millán Torne, Monica, Minnerup, Jens, Modrau, Boris, Pedraza, Salvador, Moeller, Sebastian, Møller, Anette, Morel, Nathalie, Moreton, Fiona, Morin, Ludovic, Moulin, Thierry, Moynihan, Barry, Mueller, Anne K., Muir, Keith W., Mulero, Patricia, Schellinger, Peter D, Mundiyanapurath, Sibu, Mutzenbach, Johannes, Nagel, Simon, Naggara, Oliver, Nallasivan, Arumugam, Navalpotro, Irene, Nave, Alexander H., Nederkoorn, Paul, Neeb, Lars, Neugebauer, Hermann, Schwab, Stefan, Neumann-Haefelin, Tobias, Oberndorfer, Stefan, Opherk, Christian, Oppel, Lorenz, Oppenheim, Catherine, Orthgieß, Johannes, Ostergaard, Leif, Paindeville, Perrine, Palomeras, Ernest, Koga, Masatoshi, Simonsen, Claus Z, Panitz, Verena, Patel, Bhavni, Peeters, Andre, Peeters, Dirk, Pellisé, Anna, Pelz, Johann, Pereira, Anthony, Pérez de la Ossa, Natalia, Perry, Richard, Petraza, Salvador, Song, Shlee S, Peysson, Stéphane, Pfeilschifter, Waltraud, Pichler, Alexander, Pierskalla, Alexandra, Pledl, Hans-Werner, Poli, Sven, Pomrehn, Katrin, Poulsen, Marika, Prats, Luis, Presas, Silvia, Thijs, Vincent, Prohaska, Elisabeth, Puetz, Volker, Puig, Josep, Puig Alcántara, Josep, Purrucker, Jan, Quenardelle, Veronique, Ramachandran, Sankaranarayanan, Raphaelle, Soulliard, Raposo, Nicolas, Reiff, Tilman, Toni, Danilo, Remmers, Michel, Renou, Pauline, Ribitsch, Martin, Richter, Hardy, Ringleb, Peter, Ritter, Martin, Ritzenthaler, Thomas, Rodier, Gilles, Rodriguez-Regent, Christine, Rodríguez-Yáñez, Manuel, Hsu, Chung Y, Roennefarth, Maria, Roffe, Christine, Rosenbaum, Sverre, Rosso, Charlotte, Röther, Joachim, Rozanski, Michal, Ruiz de Morales, Noelia, Russo, Francesca, Rutgers, Matthieu, Sagnier, Sharmilla, Wahlgren, Nils, Samson, Yves, Sánchez, Josep, Sauer, Tamara, Schäfer, Jan H., Schieber, Simon, Schill, Josef, Schlak, Dennis, Schlemm, Ludwig, Schmidt, Sein, Schonewille, Wouter, Yamamoto, Haruko, Schröder, Julian, Schulz, Andreas, Schurig, Johannes, Schwarting, Sönke, Schwarz, Alexander, Schwarzbach, Christopher, Seidel, Matthias, Seiler, Alexander, Sembill, Jochen, Serena Leal, Joaquin, Yassi, Nawaf, Shetty, Ashit, Sibon, Igor, Simonsen, Claus Z., Singer, Oliver, Sivagnanaratham, Aravinth, Smets, Ide, Smith, Craig, Soors, Peter, Sprigg, Nikola, Spruegel, Maximilian, Yoshimura, Sohei, Stark, David, Steinert, Susanne, Stösser, Sebastian, Stuermlinger, Markus, Swinnen, Bart, Tamazyan, Ruben, Tembl, Jose, Terceno Izaga, Mikel, Warach, Steven, Touze, Emmanuel, Truelsen, Thomas, Turc, Guillaume, Turine, Gaetane, Tütüncü, Serdar, Tyrell, Pippa, Ustrell, Xavier, Vadot, Wilfried, Vallet, Anne-Evelyne, Vallet, Pauline, Hacke, Werner, van den Berg, Lucie, van den Berg, Sophie, van Eendenburg, Cecile, Van Hooff, Robbert-Jan, van Sloten, Isabelle, Vanacker, Peter, Vancaester, Evelien, Vanderdonckt, Patrick, Vandermeeren, Yves, Vanhee, Frederik, Toyoda, Kazunori, Veltkamp, Roland, Vestergaard, Karsten, Viguier, Alain, Vilas, Dolores, Villringer, Kersten, Voget, Dieke, von Schrader, Jörg, von Weitzel, Paul, Warburton, Elisabeth, Weber, Claudia, Donnan, Geoffrey A, Weber, Jörg, Wegscheider, Karl, Wegscheider, Mirko, Weimar, Christian, Weinstich, Karin, Weise, Christopher, Weise, Gesa, Willems, Chris, Winder, Klemens, Wittayer, Matthias, Davis, Stephen M, Wolf, Marc, Wolf, Martin, Wolff, Valerie, Wollboldt, Christian, Wollenweber, Frank, Wouters, Anke, Yalo, Bertrand, Yger, Marion, Younan, Nadia, Yperzeele, Laetita, Zegarac, Vesna, Zeiner, Pia, Ziemann, Ulf, Zonneveld, Thomas, Zuber, Mathieu, Akutsu, Tsugio, Aoki, Junya, Arakawa, Shuji, Doijiri, Ryosuke, Acosta, Boris Raul, Egashira, Yusuke, Enomoto, Yukiko, Furui, Eisuke, Furuta, Konosuke, Gotoh, Seiji, Hamasaki, Toshimitsu, Hasegawa, Yasuhiro, Hirano, Teryuki, Homma, Kazunari, Aegidius, Karen, Ichijyo, Masahiko, Ide, Toshihiro, Igarashi, Shuichi, Iguchi, Yasuyuki, Ihara, Masafumi, Ikenouchi, Hajime, Inoue, Tsuyoshi, Itabashi, Ryo, Ito, Yasuhiro, Albiker, Christian, Iwama, Toru, Kamiyama, Kenji, Kamiyoshi, Shoko, Kanai, Haruka, Kanematsu, Yasuhisa, Kanzawa, Takao, Kimura, Kazumi, Kitayama, Jiro, Kitazono, Takanari, Alegiani, Anna, Kondo, Rei, Kudo, Kohsuke, Kusumi, Masayoshi, Kuwahara, Ken, Matsumoto, Shoji, Matsuoka, Hideki, Mihara, Ban, Minematsu, Kazuo, Miura, Ken, Almendrote, Miriam, Morita, Naomi, Mouri, Wataru, Murata, Kayo, Nagakane, Yoshinari, Nakase, Taizen, Ohara, Hiromi, Ohara, Nobuyuki, Ohnishi, Hideyuki, Ohta, Hajime, Ohtaki, Masafumi, Schwamm, Lee H, Alonso, Angelika, Ohtani, Ryo, Ohtsuki, Toshiho, Ohyama, Hideo, Okada, Takashi, Okada, Yasushi, Osaki, Masato, Sakai, Nobuyuki, Sanbongi, Yoshiki, Sasaki, Naoshi, Sasaki, Makoto, Althaus, Katharina, Sato, Shoichiro, Seki, Kenta, Shimizu, Wataru, Shiokawa, Yoshiaki, Sozu, Takashi, Suzuki, Junichiro, Suzuki, Rieko, Takagi, Yasushi, Takizawa, Shunya, Tanahashi, Norio, Amarenco, Pierre, Tanaka, Eijiro, Tanaka, Ryota, Tateishi, Yohei, Terada, Tomoaki, Terasaki, Tadashi, Todo, Kenichi, Tokunaga, Azusa, Tsujino, Akira, Ueda, Toshihiro, Amiri, Hemasse, Uesaka, Yoshikazu, Uotani, Mihoko, Urabe, Takao, Watanabe, Masao, Yagita, Yoshiki, Yakushiji, Yusuke, Yasui, Keizo, Yonehara, Toshiro, Anders, Bettina, Yoshimura, Shinichi, Aarnio, K., Alemseged, F., Anderson, C., Ang, T., Archer, M. L., Attia, J., Bailey, P., Balabanski, A., Barber, A., Aniculaesei, Adriana, Barber, P. A., Bernhardt, J., Bivard, A., Blacker, D., Bladin, C. F., Brodtmann, A., Cadilhac, D., Campbell, B. C. V., Carey, L., Celestino, S., Appleton, Jason, Chan, L., Chang, W. H., ChangI, A., Chen, C. H., Chen, C.-I., Chen, H. F., Chen, T. C., Chen, W. H., Chen, Y. Y., Cheng, C. A., Arenillas, Juan, Cheong, E., Chiou, Y. W., Choi, P. M., Chu, H. J., Chuang, C. S., Chung, T. C., Churilov, L., Clissold, B., Connelly, A., Coote, S., Back, Christina, Coulton, B., Cowley, E., Cranefield, J., Curtze, S., D'Este, C., Davis, S. M., Day, S., Desmond, P. M., Dewey, H. M., Ding, C., Bähr, Christian, Donnan, G. A., Drew, R., Eirola, S., Field, D., Frost, T., Garcia-Esperon, C., George, K., Gerraty, R., Grimley, R., Guo, Y. C., Wu, Ona, Bardutzky, Jürgen, Hankey, G., Harvey, J., Ho, S. C., Hogan, K., Howells, D., Hsiao, P. M., Hsu, C. H., Hsu, C. T., Hsu, C.-S., Hsu, J. P., Baronnet-Chauvet, Flore, Hsu, Y. D., Hsu, Y. T., Hu, C. J., Huang, C. C., Huang, H. Y., Huang, M. Y., Huang, S. C., Huang, W. S., Jackson, D., Jeng, J. S., Bathe-Peters, Rouven, Jiang, S. K., Kaauwai, L., Kasari, O., King, J., Kleinig, T. J., Koivu, M., Kolbe, J., Krause, M., Kuan, C. W., Kung, W. L., Bayer-Karpinska, Anna, Kyndt, C., Lau, C. L., Lee, A., Lee, C. Y., Lee, J. T., Lee, Y., Lee, Y. C., Levi, C., Levi, C. R., Lien, L. M., Becerra, Juan L., Lim, J. C., Lin, C. C., Lin, C. H., Lin, C. M., Lin, D., Liu, J., Lo, Y. C., Loh, P. S., Low, E., Lu, C. H., Beck, Christoph, Lu, C. J., Lu, M. K., Ly, J., Ma, H., Macaulay, L., Macdonnell, R., Mackey, E., Macleod, M., Mahadevan, J., Maxwell, V., Belchí Guillamon, Olga, McCoy, R., McDonald, A., McModie, S., Meretoja, A., Mishra, S., Mitchell, P. J., Miteff, F., Moore, A., Muller, C., Ng, F., Benoit, Amandine, Ng, F. C., Ng, J-L., O'Brian, W., O'Collins, V., Oxley, T. J., Parsons, M. W., Patel, S., Peng, G. S., Pesavento, L., Phan, T., Berhoune, Nadia, Rodrigues, E., Ross, Z., Sabet, A., Sallaberger, M., Salvaris, P., Shah, D., Sharma, G., Sibolt, G., Simpson, M., Singhal, S., Bindila, Daniela, Snow, B., Spratt, N., Stark, R., Sturm, J., Sun, M. C., Sun, Y., Sung, P. S., Sung, Y. F., Suzuki, M., Tan, M., Bendszus, Martin, Birchenall, Julia, Tang, S. C., Tatlisumak, T., Thijs, V., Tiainen, M., Tsai, C. H., Tsai, C. K., Tsai, C. L., Tsai, H. T., Tsai, L. K., Tseng, C. H., Blanc-Lasserre, Karine, Tseng, L. T., Tsoleridis, J., Tu, H., Tu, H. T-H., Vallat, W., Virta, J., Wang, W. C., Wang, Y. T., Waters, M., Weir, L., Blanco Gonzales, Miguel, Wijeratne, T., Williams, C., Wilson, W., Wong, A. A., Wong, K., Wu, T. Y., Wu, Y. H., Yan, B., Yang, F. C., Yang, Y. W., Bobinger, Tobias, Yassi, N., Yeh, H. L., Yeh, J. H., Yeh, S. J., Yen, C. H., Young, D., Ysai, C. L., Zhang, W. W., Zhao, H., Zhao, L., Bodechtel, Ulf, Althaus-Knaurer, Katharina, Berrouschot, Jörg, Bluhmki, Erich, Bovi, Paolo, Chatellier, Gilles, Cove, Lynda, Davis, Stephen, Dixit, A., Donnan, Geoffrey, Bodiguel, Eric, Ehrenkrona, Christina, Eschenfelder, Christoph, Fatar, Marc, Francisco Arenillas, Juan, Gruber, Franz, Kala, Lalit, Kapeller, Peter, Kaste, Markku, Bojaryn, Urszula, Kessler, Christof, Köhrmann, Martin, Laage, Rico, Lees, Kennedy R., Luna Rodriguez, Alain, Mas, Jean-Louis, Mikulik, Robert, Molina, Carlos, Muddegowda, Girish, Muir, Keith, Bonnet, Louise, Niederkorn, Kurt, Nuñez, Xavier, Schellinger, Peter, Serena, Joaquin, Sobesky, Jan, Steiner, Thorsten, Bouamra, Benjamin, Svenson, Ann-Sofie, von Kummer, Rüdiger, Wardlaw, Joanna, Betensky, Rebecca A., Boulouis, Gregoire, Carandang, Raphael A., Copen, William A., Bourgeois, Paul, Cougo, Pedro, Cutting, Shawna, Drake, Kendra, Ford, Andria L., Hallenbeck, John, Harris, Gordon J., Hoesch, Robert, Hsia, Amie, Kase, Carlos, Latour, Lawrence, Bladin, Christopher F, Lev, Michael H., Muzikansky, Alona, Nagaraja, Nandakumar, Schwamm, Lee H., Searls, Eric, Song, Shlee S., Starkman, Sidney, Breuer, Lorenz, Yoo, Albert J., Zand, Ramin, Breynaert, Ludovic, Broughton, David, Brouns, Raf, Brugirard, Sébastian, Bruneel, Bart, Buggle, Florian, Cakmak, Serkan, Calleja, Ana, Campbell, Bruce C V, Calvet, David, Carrera, David, Chen, Hsin-Chieh, Cheripelli, Bharath, Cho, Tae-Hee, Choe, Chi-un, Choy, Lillian, Christensen, Hanne, Ciatipis, Mareva
المصدر: The lancet 396(10262), 1574 - 1584 (2020). doi:10.1016/S0140-6736(20)32163-2
بيانات النشر: Elsevier
سنة النشر: 2020
مصطلحات موضوعية: info:eu-repo/classification/ddc/610
جغرافية الموضوع: DE
الوصف: BackgroundPatients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to establish whether intravenous alteplase is safe and effective in such patients when salvageable tissue has been identified with imaging biomarkers.MethodsWe did a systematic review and meta-analysis of individual patient data for trials published before Sept 21, 2020. Randomised trials of intravenous alteplase versus standard of care or placebo in adults with stroke with unknown time of onset with perfusion-diffusion MRI, perfusion CT, or MRI with diffusion weighted imaging-fluid attenuated inversion recovery (DWI-FLAIR) mismatch were eligible. The primary outcome was favourable functional outcome (score of 0–1 on the modified Rankin Scale [mRS]) at 90 days indicating no disability using an unconditional mixed-effect logistic-regression model fitted to estimate the treatment effect. Secondary outcomes were mRS shift towards a better functional outcome and independent outcome (mRS 0–2) at 90 days. Safety outcomes included death, severe disability or death (mRS score 4–6), and symptomatic intracranial haemorrhage. This study is registered with PROSPERO, CRD42020166903.FindingsOf 249 identified abstracts, four trials met our eligibility criteria for inclusion: WAKE-UP, EXTEND, THAWS, and ECASS-4. The four trials provided individual patient data for 843 individuals, of whom 429 (51%) were assigned to alteplase and 414 (49%) to placebo or standard care. A favourable outcome occurred in 199 (47%) of 420 patients with alteplase and in 160 (39%) of 409 patients among controls (adjusted odds ratio [OR] 1·49 [95% CI 1·10–2·03]; p=0·011), with low heterogeneity across studies (I2=27%). Alteplase was associated with a significant shift towards better functional outcome (adjusted common OR 1·38 [95% CI 1·05–1·80]; p=0·019), and a higher odds of independent outcome (adjusted OR 1·50 [1·06–2·12]; p=0·022). In the alteplase group, 90 (21%) patients were severely disabled or died (mRS score 4–6), ...
نوع الوثيقة: article in journal/newspaper
اللغة: English
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/pmid:33176180; info:eu-repo/semantics/altIdentifier/issn/0023-7507; info:eu-repo/semantics/altIdentifier/issn/0099-5355; info:eu-repo/semantics/altIdentifier/issn/1474-547X; info:eu-repo/semantics/altIdentifier/issn/0140-6736; https://pub.dzne.de/record/154345Test; https://pub.dzne.de/search?p=id:%22DZNE-2021-00199%22Test
الإتاحة: https://doi.org/10.1016/S0140-6736Test(20)32163-2
https://pub.dzne.de/record/154345Test
https://pub.dzne.de/search?p=id:%22DZNE-2021-00199%22Test
حقوق: info:eu-repo/semantics/closedAccess
رقم الانضمام: edsbas.5B029E87
قاعدة البيانات: BASE
الوصف
الوصف غير متاح.