المؤلفون: Chris P. M. Reutelingsperger, Marion J. Gijbels, Henri Spronk, Rene Van Oerle, Roy Schrijver, Peter Ekhart, Sjef de Kimpe, Gerry A. F. Nicolaes

المصدر: International Journal of Molecular Sciences, Vol 25, Iss 3, p 1376 (2024)

مصطلحات موضوعية: M6229, sepsis, hyperinflammation, extracellular histones, DAMPs, organ injury, Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1422-0067/25/3/1376Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/d619560b95fb4294b9ca9688d8e839f3Test

المؤلفون: Karin C A A Wildhagen, Roy Schrijver, Linda Beckers, Hugo ten Cate, Chris P M Reutelingsperger, Esther Lutgens, Gerry A F Nicolaes

المصدر: PLoS ONE, Vol 9, Iss 7, p e101446 (2014)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC4102480?pdf=renderTest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/dc009b25dd374f87926379fe14bdd14dTest

المؤلفون: H. Coenraad Hemker, Roy Schrijver, Chris P. M. Reutelingsperger, Danielle M. H. Beurskens, Joram Huckriede, Gerry A. F. Nicolaes

المصدر: Thrombosis and Haemostasis. 120:1371-1383

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, medicine.medical_specialty, medicine.drug_class, Anti-Inflammatory Agents, Antineoplastic Agents, 030204 cardiovascular system & hematology, ACTIVATED PROTEIN-C, KAPPA-B ACTIVATION, ANTI-COAGULANT, 03 medical and health sciences, 0302 clinical medicine, LOW-MOLECULAR-WEIGHT, medicine, metastasis, Animals, Humans, Anticoagulant use, In patient, Neoplasm Metastasis, anticoagulation, Intensive care medicine, PATHWAY INHIBITOR, Blood Coagulation, Beneficial effects, FIBROBLAST-GROWTH-FACTOR, UNFRACTIONATED HEPARIN, Heparin, business.industry, P-SELECTIN, Anticoagulant, Anticoagulants, Hematology, medicine.disease, ENDOTHELIAL-CELLS, Pulmonary embolism, Review article, 030104 developmental biology, inflammation, Intercellular Signaling Peptides and Proteins, business, Venous thromboembolism, CELL-ADHESION, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26df757fbd1bb6c4551e6d439e730b9Test
https://doi.org/10.1055/s-0040-1715460Test

المؤلفون: Marion A.H. Feijge, Roy Schrijver, Stella Thomassen, Judith M.E.M. Cosemans, Alan E. Mast, Kristien Winckers, Johan W. M. Heemskerk, Tilman M. Hackeng, Frauke Swieringa, Susan A. Maroney, Tom G. Mastenbroek

المساهمون: Biochemie, RS: CARIM - R1.03 - Cell biochemistry of thrombosis and haemostasis, MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), RS: CARIM - R1.01 - Blood proteins & engineering

المصدر: Thrombosis and Haemostasis, 118(3), 502-513. Georg Thieme Verlag

مصطلحات موضوعية: Male, 0301 basic medicine, FACTOR VIIA, PROTEIN-S, 030204 cardiovascular system & hematology, Mice, 0302 clinical medicine, fibrin clot formation, Platelet, BLOOD-COAGULATION, biology, Chemistry, Hematology, Thrombosis, Healthy Volunteers, EMBRYONIC-DEVELOPMENT, Cell biology, Perfusion, Coagulation, thrombin generation, Factor Xa, platelets, Female, Collagen, KEY ROLE, Blood Platelets, Heterozygote, VON-WILLEBRAND-FACTOR, Lipoproteins, haemophilia, Hemophilia A, Hemophilia B, TFPI, Article, Fibrin, Thromboplastin, 03 medical and health sciences, Tissue factor, Tissue factor pathway inhibitor, Von Willebrand factor, medicine, Animals, Humans, Integrin Alpha-IIb/Beta-3, Blood Coagulation, Crosses, Genetic, mouse, INTEGRIN ALPHA(IIB)BETA(3), Coagulants, FACTOR-X ACTIVATION, Anticoagulants, medicine.disease, Mice, Inbred C57BL, THROMBUS FORMATION, 030104 developmental biology, biology.protein

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1767a7e6e3eb64c095dffa377ffb40ecTest
https://cris.maastrichtuniversity.nl/en/publications/e71a3eee-d255-464b-9cb3-71522d140e8dTest

المؤلفون: Janneke Horn, Maryse A. Wiewel, Tom van der Poll, Marcus J. Schultz, Karin C. A. A. Wildhagen, Roy Schrijver, Chris P. M. Reutelingsperger, Gerry A. F. Nicolaes

المساهمون: Graduate School, AII - Amsterdam institute for Infection and Immunity, Intensive Care Medicine, ANS - Amsterdam Neuroscience, Infectious diseases, Center of Experimental and Molecular Medicine, Promovendi CD, Biochemie, RS: CARIM - R1 - Thrombosis and haemostasis

المصدر: Thrombosis research, 136(3), 542-547. Elsevier Limited
Thrombosis Research, 136(3), 542-547. Elsevier Science

مصطلحات موضوعية: Male, medicine.medical_specialty, Thrombin generation, Antithrombin, Inflammation, Biology, Sensitivity and Specificity, Antithrombins, law.invention, Sepsis, Histones, chemistry.chemical_compound, law, Risk Factors, Internal medicine, Lactate dehydrogenase, medicine, Extracellular, Humans, Platelet, Mortality, Tissue homeostasis, Hydro-Lyases, Netherlands, Platelet Count, Incidence, Reproducibility of Results, NETosis, Hematology, Middle Aged, medicine.disease, Prognosis, Intensive care unit, Survival Rate, Endocrinology, chemistry, Immunology, Female, medicine.symptom, Biomarkers, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f38d944b46cacbae0691d1432d6f78Test
https://cris.maastrichtuniversity.nl/en/publications/183d6dc8-7668-4e10-bf40-bf83d8065d63Test

المؤلفون: Claudia M. van Tiel, Roy Schrijver, Dorothee Atzler, Aldo Jongejan, Oliver Soehnlein, Marnix Lameijer, Menno P.J. de Winther, Francois Fay, Suzanne A. B. M. Aarts, Barbara Zarzycka, Bram Slütter, Christian Weber, Jun Tang, Perry D. Moerland, Norbert Gerdes, Boris Bleijlevens, Myrthe den Toom, Raphaël Duivenvoorden, Esther Lutgens, Tom Seijkens, Linda Beckers, Pascal J. H. Kusters, Remco T. A. Megens, Marion J.J. Gijbels, Gijs Kooij, Cornelis van 't Veer, Johan Kuiper, Gerry A. F. Nicolaes, Gert Vriend, Louis Boon, Edward A. Fisher, Willem J. M. Mulder, Samantha Baxter, Johan Duchene, Maria Aslani, Marten A. Hoeksema

المساهمون: Biomedische Technologie, Promovendi CD, Biochemie, Moleculaire Genetica, Pathologie, RS: CARIM - R3.06 - The vulnerable plaque: makers and markers, RS: CARIM - R2.06 - Intermediate cardiac metabolism, RS: CARIM - R3.07 - Structure-function analysis of the chemokine interactome for therapeutic targeting and imaging in atherosclerosis, RS: CARIM - R1.01 - Blood proteins & engineering, Medical Biochemistry, ACS - Amsterdam Cardiovascular Sciences, Graduate School, Other departments, Center of Experimental and Molecular Medicine, APH - Methodology, Epidemiology and Data Science, APH - Personalized Medicine, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Other Research, Nephrology, ACS - Atherosclerosis & ischemic syndromes, ACS - Pulmonary hypertension & thrombosis, Molecular cell biology and Immunology, Amsterdam Neuroscience - Neuroinfection & -inflammation

المصدر: Journal of the American College of Cardiology, 71(5), 527-542. Elsevier Science
Journal of the American College of Cardiology
Journal of the American College of Cardiology, 71(5), 527-542
Journal of the American College of Cardiology, 71, 5, pp. 527-542
Journal of the American College of Cardiology, 71(5), 527-542. Elsevier USA
Seijkens, T T P, van Tiel, C M, Kusters, P J H, Atzler, D, Soehnlein, O, Zarzycka, B, Aarts, S A B M, Lameijer, M, Gijbels, M J, Beckers, L, den Toom, M, Slütter, B, Kuiper, J, Duchene, J, Aslani, M, Megens, R T A, van ‘t Veer, C, Kooij, G, Schrijver, R, Hoeksema, M A, Boon, L, Fay, F, Tang, J, Baxter, S, Jongejan, A, Moerland, P D, Vriend, G, Bleijlevens, B, Fisher, E A, Duivenvoorden, R, Gerdes, N, de Winther, M P J, Nicolaes, G A, Mulder, W J M, Weber, C & Lutgens, E 2018, ' Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis ', Journal of the American College of Cardiology, vol. 71, no. 5, pp. 527-542 . https://doi.org/10.1016/j.jacc.2017.11.055Test, https://doi.org/10.1016/j.jacc.2017.11.055Test
Journal of the American College of Cardiology, 71, 527-542

مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein E, MECHANISM, rHDL, recombinant high-density lipoprotein, Cell Culture Techniques, 030204 cardiovascular system & hematology, PHENOTYPE, THERAPY, Monocytes, ACTIVATION, immunology, Mice, DC, dendritic cell, 0302 clinical medicine, Cell Movement, TRAF, tumor necrosis factor receptor-associated factor, CD40, Medicine, Propiophenones, Aniline Compounds, biology, nanotechnology, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, BMDM, bone marrow-derived macrophage, Plaque, Atherosclerotic, 3. Good health, medicine.anatomical_structure, Apoe, apolipoprotein E, Tumor necrosis factor alpha, medicine.symptom, Cardiology and Cardiovascular Medicine, CD40-TRAF6 INTERACTIONS, Signal Transduction, Bioinformatics, CD40 Ligand, INHIBITION, Inflammation, CVD, cardiovascular disease, Article, 03 medical and health sciences, Immune system, Animals, Humans, TNF Receptor-Associated Factor 6, SMI, small molecule inhibitor, business.industry, Monocyte, Macrophages, Germinal center, drug development, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Immunoglobulin class switching, inflammation, CELLS, Cancer research, biology.protein, IMMUNE-SYSTEM, atherosclerosis, business, Nanomedicine Radboud Institute for Molecular Life Sciences [Radboudumc 19]

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca6a3b34a4eaed1e2703cd007d5bc8dTest
https://doi.org/10.1016/j.jacc.2017.11.055Test

المؤلفون: Roy Schrijver, Oliver Soehnlein, Claudia M. van Tiel, Tom Seijkens, Barbara Zarzycka, Tina Ritschel, Tilman M. Hackeng, Sander B. Nabuurs, Jochen Grommes, Gert Vriend, Esther Lutgens, Fabian Giehler, Arnd Kieser, Christian Weber, Gerry A. F. Nicolaes

المساهمون: Promovendi CD, Pathologie, Biochemie, RS: CARIM - R1 - Thrombosis and haemostasis, RS: CARIM - R3 - Vascular biology, Medical Biochemistry, Pathology, ACS - Amsterdam Cardiovascular Sciences, AII - Amsterdam institute for Infection and Immunity

المصدر: Journal of Chemical Information and Modeling, 55(2), 294-307. American Chemical Society
Journal of chemical information and modeling, 55(2), 294-307. American Chemical Society
Journal of Chemical Information and Modeling, 55, 2, pp. 294-307
Journal of Chemical Information and Modeling, 55, 294-307

مصطلحات موضوعية: Male, Models, Molecular, Receptor complex, General Chemical Engineering, Anti-Inflammatory Agents, Inflammation, Peritonitis, Library and Information Sciences, Pharmacology, Biology, Ligands, Cell Line, Small Molecule Libraries, Mice, Sepsis, Drug Discovery, medicine, Animals, CD40 Antigens, TNF Receptor-Associated Factor 6, Drug discovery, Signal transducing adaptor protein, General Chemistry, Peptide Fragments, High-Throughput Screening Assays, Computer Science Applications, Cell biology, Mice, Inbred C57BL, Molecular Docking Simulation, Drug development, Docking (molecular), Tumor necrosis factor alpha, medicine.symptom, Nanomedicine Radboud Institute for Molecular Life Sciences [Radboudumc 19], CD40 signaling pathway, Databases, Chemical, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f08cd0f10fbe5082265c09cd8195e62Test
https://doi.org/10.1021/ci500631eTest

المؤلفون: Gerry A. F. Nicolaes, Olivier Sperandio, Roy Schrijver, Bruno O. Villoutreix, Karin C. A. A. Wildhagen, Simone J.H. Wielders

المساهمون: Promovendi CD, Ondersteunend personeel CD, Biochemie, RS: CARIM - R1 - Thrombosis and haemostasis

المصدر: Thrombosis Research, 133(6), 1105-1114. Elsevier Science

مصطلحات موضوعية: Models, Molecular, Virtual screening, Protein Data Bank (RCSB PDB), Drug Evaluation, Preclinical, Drug design, Small Molecule Libraries, Structure-Activity Relationship, Thrombin, medicine, Humans, Binding site, Protein C Inhibitor, chemistry.chemical_classification, Binding Sites, Chemistry, Binding protein, Hematology, computer.file_format, Surface Plasmon Resonance, Protein Data Bank, Small molecule, Enzyme, Activated protein C, Biochemistry, Factor Va, computer, medicine.drug, Protein C

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cc4cf2e16c7771e3d0bf2c052c7733Test
https://doi.org/10.1016/j.thromres.2014.01.026Test

المؤلفون: Linda Beckers, Gerry A. F. Nicolaes, Hugo ten Cate, Chris P. M. Reutelingsperger, Karin C. A. A. Wildhagen, Roy Schrijver, Esther Lutgens

المساهمون: Promovendi CD, Ondersteunend personeel NTM, MUMC+: MA Alg Interne Geneeskunde (9), Interne Geneeskunde, Pathologie, Biochemie, RS: CARIM - R1 - Thrombosis and haemostasis, RS: CARIM - R3 - Vascular biology, Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam institute for Infection and Immunity

المصدر: PLoS ONE, Vol 9, Iss 7, p e101446 (2014)
PLoS ONE
PLOS ONE, 9(7):e101446. Public Library of Science
PLoS ONE, 9(7), e101446-(10 p.). Public Library of Science

مصطلحات موضوعية: Male, Myocardial Infarction, lcsh:Medicine, Biochemistry, Vascular Medicine, Mice, Spectrum Analysis Techniques, Ischemia, Medicine and Health Sciences, Receptor, lcsh:Science, Immune Response, Chemokine CCL2, Mice, Knockout, Endothelial protein C receptor, Innate Immune System, Multidisciplinary, Endothelial Protein C Receptor, Heart, Animal Models, Flow Cytometry, Recombinant Proteins, Interleukin-10, Spectrophotometry, Reperfusion Injury, Cytokines, Cytophotometry, medicine.symptom, Coagulation Factors, medicine.drug, Research Article, medicine.medical_specialty, Immunology, Cardiology, Inflammation, Mouse Models, Receptors, Cell Surface, CCL2, Research and Analysis Methods, Cell Line, Thrombin, Model Organisms, Apolipoproteins E, Antigens, CD, Internal medicine, medicine, Animals, Humans, Receptor, PAR-1, Animal Models of Disease, Immunoassays, Immunohistochemistry Techniques, business.industry, Interleukin-6, lcsh:R, Biology and Life Sciences, Proteins, Molecular Development, medicine.disease, Atherosclerosis, Histochemistry and Cytochemistry Techniques, Mice, Inbred C57BL, Endocrinology, HEK293 Cells, Cytoprotection, Immune System, Animal Studies, Immunologic Techniques, lcsh:Q, business, Reperfusion injury, Protein C, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842f2d90df0a2bf5ef2c8e81a88397e4Test
http://europepmc.org/articles/PMC4102480?pdf=renderTest

المؤلفون: Bruno O. Villoutreix, Jan Voorberg, Paul H. P. Kaijen, Roy Schrijver, Aleksandra Wroblewska, Mahesh Kulharia, Gerry A. F. Nicolaes, Olivier Sperandio, Simone J.H. Wielders

المساهمون: ACS - Amsterdam Cardiovascular Sciences, Experimental Vascular Medicine, Biochemie, Ondersteunend personeel CD, RS: CARIM - R1 - Thrombosis and haemostasis

المصدر: Blood, 123(1), 113-120. American Society of Hematology
Blood, 123(1), 113-120. The American Society of Hematology

مصطلحات موضوعية: Models, Molecular, congenital, hereditary, and neonatal diseases and abnormalities, Protein Conformation, Surface Properties, animal diseases, Immunology, Ligands, Biochemistry, Cofactor, Inhibitory Concentration 50, Plasma, Thrombin, In vivo, hemic and lymphatic diseases, medicine, Humans, C2 domain, Factor VIII, biology, Dose-Response Relationship, Drug, Chemistry, Rational design, Anticoagulants, Cell Biology, Hematology, Surface Plasmon Resonance, Small molecule, Cell biology, Protein Structure, Tertiary, Blood, Coagulation, Drug Design, biology.protein, Function (biology), medicine.drug, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299fd3d6e68b05c33d68e138247b1258Test
https://pure.amc.nl/en/publications/rational-design-of-small-molecules-targeting-the-c2-domain-of-coagulation-factor-viiiTest(394bbc01-cac5-4822-9ff6-c2f7fc2f03f4).html