The effect of treatment on quality of life in patients with acromegaly: a prospective study
| العنوان: | The effect of treatment on quality of life in patients with acromegaly: a prospective study |
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| المؤلفون: | Margreet A E M Wagenmakers, Thalijn L C Wolters, Olga Husson, Rosalie Btm Sterenborg, Sean H.P.P. Roerink, Ad R. M. M. Hermus, Jan Smit, Romana T. Netea-Maier |
| المساهمون: | Internal Medicine |
| المصدر: | European Journal of Endocrinology, 182, 3, pp. 319-331 European Journal of Endocrinology, 182, 319-331 European Journal of Endocrinology, 182, 319-331. Bioscientifica Ltd |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Health Status, Health change, Population, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], 030209 endocrinology & metabolism, Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9], Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], 03 medical and health sciences, Young Adult, 0302 clinical medicine, Endocrinology, Postoperative Complications, Sex Factors, All institutes and research themes of the Radboud University Medical Center, Quality of life, Internal medicine, Surveys and Questionnaires, Acromegaly, Medicine, Humans, In patient, Prospective Studies, Young adult, Insulin-Like Growth Factor I, Prospective cohort study, education, Aged, education.field_of_study, business.industry, Human Growth Hormone, General Medicine, Middle Aged, medicine.disease, Hormones, Self Concept, Treatment Outcome, 030220 oncology & carcinogenesis, Quality of Life, Female, business, After treatment |
| الوصف: | Objective Acromegaly has a negative influence on health-related quality of life (HRQoL). Previous studies provide limited information on the course of HRQoL during treatment. This study aims to assess the effect of treatment on the course of HRQoL at six predefined time points. Design This prospective study examines HRQoL in treatment-naive patients before and during the first 2.5 years of acromegaly treatment. Methods Therapy-naive acromegaly patients completed three validated questionnaires (RAND-36, AcroQoL, and the Appearance Self-Esteem (ASE)) at six predetermined time points before, during, and after treatment. Outcomes were correlated to IGF1 levels and disease control status. Results Twenty-seven acromegaly patients completed the questionnaires at all time points. After treatment, all patients had controlled acromegaly. Scores of RAND-36 domains General health, Vitality and Health change, and all AcroQoL dimensions (except for Relations) improved during treatment (P ≤ 0.003); the largest changes were detected during the first year. Gender influenced HRQoL scores, since AcroQoL scores significantly improved in males but not in females. Over time, IGF1 levels were negatively correlated with HRQoL. After 2.5 years of follow-up, HRQoL of controlled patients was still lower than in the general population. Conclusion HRQoL of acromegaly patients was considerably reduced at diagnosis. Disease control was associated with an improvement of HRQoL scores. Males showed a more pronounced improvement than females. The largest changes were detected in the first year of treatment. However, HRQoL during and after treatment remained impaired in acromegaly patients, emphasizing the need of additional support. |
| وصف الملف: | application/pdf |
| تدمد: | 0804-4643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c28b329b005745ac795c7d3a40106eTest https://hdl.handle.net/2066/217592Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a5c28b329b005745ac795c7d3a40106e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08044643 |
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