المؤلفون: Nele Van Der Steen, Karen Zwaenepoel, Giulia Mazzaschi, Rosa A. Luirink, Daan P. Geerke, Ken Op de Beeck, Christophe Hermans, Marcello Tiseo, Paul Van Schil, Filip Lardon, Paul Germonpré, Christian Rolfo, Elisa Giovannetti, Godefridus J. Peters, Patrick Pauwels

المصدر: Molecules; Volume 24; Issue 24; Pages: 4443

مصطلحات موضوعية: NSCLC, c-Met, EGFR, biomarkers

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules24244443Test

الإتاحة: https://doi.org/10.3390/molecules24244443Test

المؤلفون: Felix M. Paulussen, Gina K. Schouten, Carolin Moertl, Jolanda Verheul, Irma Hoekstra, Gregory M. Koningstein, George H. Hutchins, Aslihan Alkir, Rosa A. Luirink, Daan P. Geerke, Peter van Ulsen, Tanneke den Blaauwen, Joen Luirink, Tom N. Grossmann

المصدر: Journal of the American Chemical Society. 144(33)

مصطلحات موضوعية: Colloid and Surface Chemistry, Bacterial Proteins, Escherichia coli Proteins, Escherichia coli, Animals, Membrane Proteins, Cell Cycle Proteins, General Chemistry, Biochemistry, Catalysis, Zebrafish, Anti-Bacterial Agents

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3c685c7ec6cad6f37fb845aeb2ae85Test
https://pubmed.ncbi.nlm.nih.gov/35945166Test

المؤلفون: Marlies C. A. Verkade-Vreeker, Jan N. M. Commandeur, Rosa A. Luirink, Daan P. Geerke

المساهمون: AIMMS, Molecular and Computational Toxicology

المصدر: ChemBioChem, 21(10), 1461-1472. Wiley-VCH Verlag
Chembiochem
Luirink, R A, Verkade-Vreeker, M C A, Commandeur, J N M & Geerke, D P 2020, ' A Modified Arrhenius Approach to Thermodynamically Study Regioselectivity in Cytochrome P450-Catalyzed Substrate Conversion ', ChemBioChem, vol. 21, no. 10, pp. 1461-1472 . https://doi.org/10.1002/cbic.201900751Test

مصطلحات موضوعية: cytochrome P450, Heme, Molecular Dynamics Simulation, 010402 general chemistry, Hydroxylation, 01 natural sciences, Biochemistry, Catalysis, Enzyme catalysis, Substrate Specificity, Reaction rate, Molecular dynamics, symbols.namesake, Mefenamic Acid, thermodynamics, Cytochrome P-450 Enzyme System, Computational chemistry, SDG 7 - Affordable and Clean Energy, Molecular Biology, Arrhenius equation, validation, Binding Sites, Full Paper, 010405 organic chemistry, Chemistry, Organic Chemistry, selectivity, Substrate (chemistry), Regioselectivity, Full Papers, molecular dynamics, 0104 chemical sciences, symbols, Molecular Medicine, Selectivity, Oxidation-Reduction, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f767c67c56cae9812128734afc7311Test
https://research.vu.nl/en/publications/a534b2c1-d9cc-4312-96d6-46665930752dTest

المؤلفون: Nico P. E. Vermeulen, Daan P. Geerke, Sandra Ortega Ugalde, Jan N. M. Commandeur, Wilbert Bitter, Rosa A. Luirink

المساهمون: Molecular and Computational Toxicology, AIMMS, Molecular Microbiology

المصدر: Ortega Ugalde, S, Luirink, R A, Geerke, D P, Vermeulen, N P E, Bitter, W & Commandeur, J N M 2017, ' Engineering a self-sufficient Mycobacterium tuberculosis CYP130 by gene fusion with the reductase-domain of CYP102A1 from Bacillus megaterium ', Journal of Inorganic Biochemistry, vol. 180, 180, pp. 48 . https://doi.org/10.1016/j.jinorgbio.2017.12.003Test
Journal of Inorganic Biochemistry, 180:180. Elsevier Inc.

مصطلحات موضوعية: 0301 basic medicine, Recombinant Fusion Proteins, Molecular Dynamics Simulation, Reductase, Dextromethorphan, Methylation, Biochemistry, Catalysis, Substrate Specificity, Inorganic Chemistry, Mycobacterium tuberculosis, Inhibitory Concentration 50, 03 medical and health sciences, Bacterial Proteins, Cytochrome P-450 Enzyme System, SDG 3 - Good Health and Well-being, Humans, Cloning, Molecular, NADPH-Ferrihemoprotein Reductase, Bacillus megaterium, chemistry.chemical_classification, 030102 biochemistry & molecular biology, biology, Active site, Protein engineering, biology.organism_classification, Fusion protein, Molecular Docking Simulation, Kinetics, 030104 developmental biology, Enzyme, chemistry, Docking (molecular), biology.protein, Gene Fusion, Oxidation-Reduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa072c3ebd8a64a61a16b5eafa8016c2Test
https://doi.org/10.1016/j.jinorgbio.2017.12.003Test

المؤلفون: Marcello Tiseo, Godefridus J. Peters, Paul Germonpré, Christian Rolfo, Nele Van Der Steen, Christophe Hermans, Giulia Mazzaschi, Elisa Giovannetti, Karen Zwaenepoel, Daan P. Geerke, Patrick Pauwels, Paul Van Schil, Ken Op de Beeck, Filip Lardon, Rosa A. Luirink

المساهمون: Medical oncology laboratory, AGEM - Re-generation and cancer of the digestive system, CCA - Imaging and biomarkers, AIMMS, Molecular and Computational Toxicology

المصدر: Molecules
Volume 24
Issue 24
Molecules: a journal of synthetic chemistry and natural product chemistry
Molecules, 24(24). Multidisciplinary Digital Publishing Institute
van der Steen, N, Zwaenepoel, K, Mazzaschi, G, A Luirink, R, P Geerke, D, op de Beeck, K, Hermans, C, Tiseo, M, van Schil, P, Lardon, F, Germonpré, P, Rolfo, C, Giovannetti, E, J Peters, G & Pauwels, P 2019, ' The Role of c-Met as a Biomarker and Player in Innate and Acquired Resistance in Non-Small-Cell Lung Cancer: Two New Mutations Warrant Further Studies ', Molecules, vol. 24, no. 24 . https://doi.org/10.3390/molecules24244443Test
Molecules, 24(24):4443. Multidisciplinary Digital Publishing Institute (MDPI)
Van Der Steen, N, Zwaenepoel, K, Mazzaschi, G, Luirink, R A, Geerke, D P, De Beeck, K O, Hermans, C, Tiseo, M, Van Schil, P, Lardon, F, Germonpré, P, Rolfo, C, Giovannetti, E, Peters, G J & Pauwels, P 2019, ' The role of c-met as a biomarker and player in innate and acquired resistance in non-small-cell lung cancer : Two new mutations warrant further studies ', Molecules, vol. 24, no. 24, 4443 . https://doi.org/10.3390/molecules24244443Test

مصطلحات موضوعية: Male, Lung Neoplasms, Mutant, Pharmaceutical Science, NSCLC, Analytical Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Drug Discovery, Epidermal growth factor receptor, Neoplasm Metastasis, Receptor, 0303 health sciences, biology, Middle Aged, Proto-Oncogene Proteins c-met, 3. Good health, ErbB Receptors, Gene Expression Regulation, Neoplastic, Chemistry, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, Molecular Medicine, Biomarker (medicine), Female, Antibody, Adult, C-Met, EGFR, Article, Deep sequencing, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Biomarkers, Tumor, medicine, Humans, Physical and Theoretical Chemistry, Lung cancer, Biology, Aged, 030304 developmental biology, business.industry, Organic Chemistry, Gene Amplification, medicine.disease, chemistry, Drug Resistance, Neoplasm, Mutation, biology.protein, Cancer research, Tumor Suppressor Protein p53, business, Biomarkers

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41c017861e5a2eba24b3519c13c0ba8Test
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076355617&origin=inwardTest

المؤلفون: Carolin Mueller, Aravindan Varadajan, Tom N. Grossmann, Marjolein Glas, Jan Löwe, Tanneke den Blaauwen, Danguole Kureisaite-Ciziene, Stephen H. McLaughlin, Joen Luirink, Rosa A. Luirink, Alejandro Montón Silva

المساهمون: Medicinal chemistry, AIMMS, Molecular and Computational Toxicology, Organic Chemistry, Molecular Microbiology, LaserLaB - Molecular Biophysics, Bacterial Cell Biology & Physiology (SILS, FNWI), Institute of Interdisciplinary Studies

المصدر: mBio, 9(5):e01346-18, 1-17. American Society for Microbiology
mBio, Vol 9, Iss 5 (2018)
Kureisaite-Ciziene, D, Varadajan, A, McLaughlin, S H, Glas, M, Silva, A M, Luirink, R, Mueller, C, Blaauwen, T D, Grossmann, T N, Luirink, J & Löwe, J 2018, ' Structural analysis of the interaction between the bacterial cell division proteins FTSQ and FTSB ', mBio, vol. 9, no. 5, e01346-18, pp. 1-17 . https://doi.org/10.1128/mBio.01346-18Test
mBio, Vol 9, Iss 5, p e01346-18 (2018)
MBio, 9(5):e01346-18. American Society for Microbiology

مصطلحات موضوعية: 0301 basic medicine, FTSN, Molecular microbiology, FTSL, Cell division, Protein Conformation, DNA Mutational Analysis, 030106 microbiology, Cell Cycle Proteins, Protein structure function, Crystallography, X-Ray, Biochemistry, Microbiology, Bacterial cell structure, 03 medical and health sciences, Protein Domains, Virology, Protein Interaction Mapping, Escherichia coli, FtsZ, Bacterial cell division, Divisome, X-ray crystallography, 030304 developmental biology, 0303 health sciences, biology, 030306 microbiology, Chemistry, Escherichia coli Proteins, Membrane Proteins, Periplasmic space, QR1-502, Transmembrane protein, Cell biology, Tubulin, Membrane protein, Periplasm, biology.protein, Bacterial outer membrane, Protein structure-function, Cell Division, Gene Deletion, Protein Binding

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655786313e5ec2116dce0aed9ac161d3Test
https://doi.org/10.1128/mbio.01346-18Test

المؤلفون: Jan N. M. Commandeur, Luigi Capoferri, Cynthia L. Kuiper, Laura F.H. Janssen, J. Chris Vos, Nico P. E. Vermeulen, Rosa A. Luirink, Mehmet E. Ari, Daan P. Geerke, Stefan J. Dekker

المساهمون: AIMMS, Molecular and Computational Toxicology, Innovations in Human Health & Life Sciences, Chemistry and Pharmaceutical Sciences

المصدر: Journal of Inorganic Biochemistry, 184, 115-122. Elsevier Inc.
Luirink, R A, Dekker, S J, Capoferri, L, Kuiper, C L, Janssen, L F H, Ari, M E, Vermeulen, N P E, Vos, J C, Commandeur, J N M & Geerke, D P 2018, ' A combined computational and experimental study on selective flucloxacillin hydroxylation by cytochrome P450 BM3 variants ', Journal of Inorganic Biochemistry, vol. 184, pp. 115-122 . https://doi.org/10.1016/j.jinorgbio.2018.04.013Test

مصطلحات موضوعية: 0301 basic medicine, Magnetic Resonance Spectroscopy, animal structures, Stereochemistry, Metabolite, Mutant, Molecular Dynamics Simulation, Hydroxylation, Biochemistry, Floxacillin, Mass Spectrometry, Substrate Specificity, Docking, Flucloxacillin, Inorganic Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Catalytic Domain, Cytochrome P450 BM3, Hydroxymethyl, chemistry.chemical_classification, biology, Cytochrome P450, Protein engineering, 030104 developmental biology, Enzyme, chemistry, Docking (molecular), biology.protein, Biocatalysis, Molecular Dynamics simulations

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9937dc44bef21fac6bfe5f63344427bbTest
https://research.vu.nl/en/publications/9e064fb2-79b8-46f2-8281-8dc89356a4a2Test

المؤلفون: Rosa A. Luirink, Daan P. Geerke, Koen M. Visscher, C. Ruben Vosmeer

المساهمون: Molecular and Computational Toxicology, AIMMS

المصدر: Visscher, K M, Vosmeer, C R, Luirink, R A & Geerke, D P 2017, ' A Systematic Approach to Calibrate a Transferable Polarizable Force Field Parameter Set for Primary Alcohols ', Journal of Computational Chemistry, vol. 38, no. 8, pp. 508-517 . https://doi.org/10.1002/jcc.24702Test
Journal of Computational Chemistry, 38(8), 508-517. John Wiley and Sons Inc.

مصطلحات موضوعية: GROMOS11, Transferability, Thermodynamics, Molecular simulation, Dielectric, 010402 general chemistry, 01 natural sciences, Force field (chemistry), molecular simulation, symbols.namesake, force field parameterization, polarizable force field, Polarizability, 0103 physical sciences, Coulomb, Physics::Atomic Physics, SDG 7 - Affordable and Clean Energy, 010304 chemical physics, Chemistry, General Chemistry, 0104 chemical sciences, Computational Mathematics, symbols, Free energies, van der Waals force, Atomic physics, charge-on-spring model

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aba0df839269b9c13d6b4acd23e5ecdTest
https://research.vu.nl/en/publications/e80def09-ddb9-4e95-9b26-9581995d5583Test