التفاصيل البيبلوغرافية
| العنوان: |
Diabetes is associated with familial idiopathic normal pressure hydrocephalus:a case–control comparison with family members |
| المؤلفون: |
Räsänen, J. (Joel), Huovinen, J. (Joel), Korhonen, V. E. (Ville E.), Junkkari, A. (Antti), Kastinen, S. (Sami), Komulainen, S. (Simo), Oinas, M. (Minna), Avellan, C. (Cecilia), Frantzen, J. (Janek), Rinne, J. (Jaakko), Ronkainen, A. (Antti), Kauppinen, M. (Mikko), Lönnrot, K. (Kimmo), Perola, M. (Markus), Koivisto, A. M. (Anne M.), Remes, A. M. (Anne M.), Soininen, H. (Hilkka), Hiltunen, M. (Mikko), Helisalmi, S. (Seppo), Kurki, M. I. (Mitja I.), Jääskeläinen, J. E. (Juha E.), Leinonen, V. (Ville) |
| بيانات النشر: |
Springer Nature |
| سنة النشر: |
2020 |
| المجموعة: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| مصطلحات موضوعية: |
Comorbidities, Depression, Diabetes, Familial, Genetics, Normal pressure hydrocephalus, SFMBT1 |
| الوصف: |
Background: The pathophysiological basis of idiopathic normal pressure hydrocephalus (iNPH) is still unclear. Previous studies have shown a familial aggregation and a potential heritability when it comes to iNPH. Our aim was to conduct a novel case-controlled comparison between familial iNPH (fNPH) patients and their elderly relatives, involving multiple different families. Methods: Questionnaires and phone interviews were used for collecting the data and categorising the iNPH patients into the familial (fNPH) and the sporadic groups. Identical questionnaires were sent to the relatives of the potential fNPH patients. Venous blood samples were collected for genetic studies. The disease histories of the probable fNPH patients (n = 60) were compared with their ≥ 60-year-old relatives with no iNPH (n = 49). A modified Charlson Comorbidity Index (CCI) was used to measure the overall disease burden. Fisher’s exact test (two-tailed), the Mann–Whitney U test (two-tailed) and a multivariate binary logistic regression analysis were used to perform the statistical analyses. Results: Diabetes (32% vs. 14%, p = 0.043), arterial hypertension (65.0% vs. 43%, p = 0.033), cardiac insufficiency (16% vs. 2%, p = 0.020) and depressive symptoms (32% vs. 8%, p = 0.004) were overrepresented among the probable fNPH patients compared to their non-iNPH relatives. In the age-adjusted multivariate logistic regression analysis, diabetes remained independently associated with fNPH (OR = 3.8, 95% CI 1.1–12.9, p = 0.030). Conclusions: Diabetes is associated with fNPH and a possible risk factor for fNPH. Diabetes could contribute to the pathogenesis of iNPH/fNPH, which motivates to further prospective and gene-environmental studies to decipher the disease modelling of iNPH/fNPH. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| الإتاحة: |
http://urn.fi/urn:nbn:fi-fe2020120499447Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0Test/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0Test/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.DFD0EAD0 |
| قاعدة البيانات: |
BASE |
