دورية أكاديمية
Cohort profile : risk and risk factors for female breast cancer after treatment for childhood and adolescent cancer : an internationally pooled cohort
| العنوان: | Cohort profile : risk and risk factors for female breast cancer after treatment for childhood and adolescent cancer : an internationally pooled cohort |
|---|---|
| المؤلفون: | Wang, Yuehan, Kremer, Leontien C M, van Leeuwen, Flora E, Armstrong, Gregory T, Leisenring, Wendy, de Vathaire, Florent, Hudson, Melissa M, Kuehni, Claudia E, Arnold, Michael A, Haddy, Nadia, Demoor-Goldschmidt, Charlotte, Diallo, Ibrahima, Howell, Rebecca M, Ehrhardt, Matthew J, Moskowitz, Chaya S, Neglia, Joseph P, van der Pal, Helena J H, Robison, Leslie L, Schaapveld, Michael, Turcotte, Lucie M, Waespe, Nicolas, Ronckers, Cécile M, Teepen, Jop C, International Consortium for Pooled Studies on Subsequent Malignancies after Childhood and Adolescent Cancer |
| المصدر: | ISSN: 2044-6055 ; BMJ open, vol. 12, no. 11 (2022) e065910. |
| سنة النشر: | 2022 |
| المجموعة: | Université de Genève: Archive ouverte UNIGE |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/618, EPIDEMIOLOGY, Paediatric oncology, Paediatric radiotherapy, STATISTICS & RESEARCH METHODS, Male, Adolescent, Female, Humans, Child, Preschool, Young Adult, Adult, Breast Neoplasms / epidemiology, Breast Neoplasms / etiology, Breast Neoplasms / therapy, Neoplasms / therapy, Cancer Survivors, Cohort Studies, Risk Factors, Neoplasms, Second Primary / diagnosis, Incidence, Antineoplastic Agents / therapeutic use |
| الوصف: | Purpose: The International Consortium for Pooled Studies on Subsequent Malignancies after Childhood and Adolescent Cancer was established in 2018 to address gaps in knowledge of risk and risk factors for breast cancer subsequent to childhood/adolescent cancer by pooling individual patient data from seven cohorts. Initially, the pooled cohort will focus on three clinically relevant questions regarding treatment-related subsequent breast cancer risk in female survivors, which are the risk related to low-dose radiotherapy exposure to the chest, specific chemotherapy agents and attained age. Participants: The consortium database includes pooled data on 21 892 female survivors from seven cohorts in North America and Europe with a primary cancer diagnosis at <21 years of age, and survival ≥5 years from diagnosis. Findings to date: This is a newly established pooled study. The cohort profile summarised the data collected from each included cohort, including childhood cancer diagnosis information and treatment details (ie, radiotherapy fields and cumulative doses, and chemotherapy agents and cumulative doses for each agent). Included cohorts' follow-up started 1951-1981 and ended 2013-2021, respectively, for a median follow-up duration of 24.3 (IQR 18.0-32.8) years since primary cancer diagnosis. The median age at primary cancer diagnosis was 5.4 (IQR 2.5-11.9) years. And the median attained age at last follow-up was 32.2 (IQR 24.0-40.4) years. In all, 4240 (19.4%) survivors were treated with radiotherapy to the chest and 9308 (42.5%) with anthracyclines. At the end of the follow-up, 835 females developed a first subsequent breast cancer, including 635 invasive breast cancer only, 184 carcinomas in situ only (172 ductal carcinomas in situ and 12 lobular carcinomas in situ), and 16 with both an invasive and in situ diagnosis at the same moment. The cumulative incidences of subsequent breast cancer (both invasive and in situ) 25 and 35 years after primary cancer diagnosis were 2.2% and 6.2%, respectively. Future ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36344003; https://archive-ouverte.unige.ch/unige:174523Test; unige:174523 |
| الإتاحة: | https://doi.org/10.1136/bmjopen-2022-065910Test https://archive-ouverte.unige.ch/unige:174523Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5A969F0D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |