نتائج البحث - "Roger B. Ruggeri"

1

دورية أكاديمية

Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of actions⃞

المؤلفون: Ronald W. Clark, Roger B. Ruggeri, David Cunningham, Mark J. Bamberger

المصدر: Journal of Lipid Research, Vol 47, Iss 3, Pp 537-552 (2006)

مصطلحات موضوعية: lipid transfer, high density lipoprotein, atherosclerosis, cardiovascular disease, Biochemistry, QD415-436

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S0022227520336087Test; https://doaj.org/toc/0022-2275Test

الوصول الحر: https://doaj.org/article/65964bfc21ea4844aa60df2bb08c7a77Test

View record in DOAJ

النص الكامل

2

دورية أكاديمية

Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4

المؤلفون: Allyn T. Londregan (1463164), Karlygash Aitmakhanova (14298913), James Bennett (154826), Laura J. Byrnes (14298916), Daniel P. Canterbury (2022946), Xiayun Cheng (1322244), Thomas Christott (5902688), Jennifer Clemens (1696795), Steven B. Coffey (1463167), João M. Dias (12707543), Matthew S. Dowling (1523953), Gillian Farnie (282327), Oleg Fedorov (244326), Kimberly F. Fennell (2182748), Vicki Gamble (3807208), Carina Gileadi (1385442), Charline Giroud (5902694), Michael R. Harris (399139), Brett D. Hollingshead (9300522), Kilian Huber (625910), Magdalena Korczynska (1327899), Kimberly Lapham (1656913), Paula M. Loria (1600666), Arjun Narayanan (197239), Dafydd R. Owen (1290468), Brigitt Raux (1444024), Parag V. Sahasrabudhe (2948502), Roger B. Ruggeri (1738840), Laura Díaz Sáez (14298919), Ingrid A. Stock (1656904), Benjamin A. Thuma (2204773), Andy Tsai (1721833), Alison E. Varghese (14298922)

العلاقة: https://figshare.com/articles/journal_contribution/Discovery_of_High-Affinity_Small-Molecule_Binders_of_the_Epigenetic_Reader_YEATS4/21777304Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.2c01421.s001Test

View record in BASE

3

Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells

المؤلفون: Jordan M. Mattheisen, Chris Limberakis, Roger B. Ruggeri, Matthew S. Dowling, Christopher W. am Ende, Emilie Ceraudo, Thomas Huber, Christopher L. McClendon, Thomas P. Sakmar

المصدر: Journal of the American Chemical Society. 145:11173-11184

مصطلحات موضوعية: Colloid and Surface Chemistry, General Chemistry, Biochemistry, Catalysis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7cc5b00c6a565fcfee5f02177fdc5ebbTest
https://doi.org/10.1021/jacs.3c00972Test

4

Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4

المصدر: Journal of medicinal chemistry.

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f200505c5effa14e470509072c0e10bTest
https://pubmed.ncbi.nlm.nih.gov/36562986Test

5

A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor

المصدر: Journal of medicinal chemistry. 65(12)

مصطلحات موضوعية: Drug Discovery, Molecular Medicine, Animals, Humans, Hypoglycemic Agents, Peptides, Glucagon-Like Peptide-1 Receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff991134db369ff3aa7ceaecc2f6263eTest
https://pubmed.ncbi.nlm.nih.gov/35647711Test

6

A small-molecule oral agonist of the human glucagon-like peptide-1 receptor

مصطلحات موضوعية: chemistry.chemical_classification, Agonist, Chemistry, medicine.drug_class, Insulin, medicine.medical_treatment, Endogeny, Peptide, Pharmacology, Small molecule, Glucagon-like peptide-1, Oral administration, medicine, Receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::064b771366df377937229b83ffb7a9bfTest
https://doi.org/10.1101/2020.09.29.319483Test

7

Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis

المصدر: Angewandte Chemie International Edition. 56:16218-16222

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284063acd5910c34eb16ba576995a299Test
https://doi.org/10.1002/anie.201708744Test

8

Myeloperoxidase Inhibition Improves Ventricular Function and Remodeling After Experimental Myocardial Infarction

المؤلفون: Ingo Hilgendorf, Filip K. Swirski, Amit Kalgukar, Leonard Buckbinder, Roger B. Ruggeri, Stefan Schob, John W. Chen, Matthew Sebas, Benoit Tricot, Yoshiko Iwamoto, Christian Cortes, Benjamin Pulli, Gabriel Courties, Anping Dong, Wei Zheng, Athanasia Skoura, Muhammad Ali, Matthias Nahrendorf

المصدر: JACC: Basic to Translational Science, Vol 1, Iss 7, Pp 633-643 (2016)
JACC: Basic to Translational Science

مصطلحات موضوعية: MPO−/−, myeloperoxidase knock out, 0301 basic medicine, Cardiac function curve, lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, CNR, contrast to noise ratio, MPO, myeloperoxidase, Infarction, Inflammation, 030204 cardiovascular system & hematology, medicine.disease_cause, EDV, end-diastolic volume, PRECLINICAL RESEARCH, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, EF, ejection fraction, oxidative stress, Myocardial infarction, treatment, biology, Ventricular function, business.industry, Therapeutic effect, Ly-6C, lymphocyte antigen 6C, MPO-Gd, bis-5-hydroxytryptamide-diethylenetriaminepentaacetate-gadolinium, medicine.disease, 3. Good health, myeloperoxidase, myocardial infarction, 030104 developmental biology, inflammation, lcsh:RC666-701, Myeloperoxidase, LAR, lesion activation ratio, MI, myocardial infarction, biology.protein, Cardiology, IRI, ischemia reperfusion injury, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f865d2b9a48e7c50f62499fffc36ea2cTest
https://doi.org/10.1016/j.jacbts.2016.09.004Test

9

A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation

المؤلفون: Wanida Ruangsiriluk, Kimberly A. Stevens, Markus Boehm, Benjamin N. Rocke, Paula M. Loria, Julie Jia Li Hawkins, Thomas N. O'Connell, Tim Rolph, Roger B. Ruggeri, Philip A. Carpino, David Hepworth, Bruce A. Maguire, Donna N. Petersen

المصدر: Cell Chemical Biology. 23:1362-1371

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53acfff7de0a3694bb598b1b57596deeTest
https://doi.org/10.1016/j.chembiol.2016.08.016Test

10

Discovery of N-(piperidin-3-yl)-N-(pyridin-2-yl)piperidine/piperazine-1-carboxamides as small molecule inhibitors of PCSK9

المؤلفون: Donna N. Petersen, David W. Piotrowski, Allyn T. Londregan, Brian Raymer, Paula M. Loria, Liuqing Wei, Kim F. McClure, Gary Erik Aspnes, Jun Xiao, Chris Limberakis, Roger B. Ruggeri

المصدر: Bioorganicmedicinal chemistry letters. 28(23-24)

مصطلحات موضوعية: 0301 basic medicine, Cell Membrane Permeability, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, 010402 general chemistry, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Madin Darby Canine Kidney Cells, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Dogs, Piperidines, Drug Discovery, Potency, Animals, Humans, Protease Inhibitors, Molecular Biology, ADME, Chemistry, Organic Chemistry, PCSK9 Inhibitors, Small molecule, Amides, In vitro, 0104 chemical sciences, Piperazine, 030104 developmental biology, Molecular Medicine, Piperidine, Proprotein Convertase 9

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e0977a375ad322edf956fc104b143fTest
https://pubmed.ncbi.nlm.nih.gov/30482620Test

تنقيح النتائج