-
1
المؤلفون: Michael D. Bartberger, Michael Croghan, Carolyn Moyer, David Lloyd, Rod Cupples, Seifu Tadesse, Nobuko Nishimura, Ke Kong, Gwyneth Van, Christopher H. Fotsch, Randall W. Hungate, David J. St. Jean, Kevin Yang, Kate Ashton, Mark H. Norman, Samer Chmait, Longbin Liu, Lewis D. Pennington, Fang-Tsao Hong, Matthew P. Bourbeau, Clarence Hale, Jiandong Zhang, Aaron C. Siegmund, Jie Chen, Christopher M. Tegley, Steven R. Jordan, Kristin L. Andrews, Klaus Michelsen, Guomin Yao, Glenn Sivits, Andreas Reichelt, Joan Helmering
المصدر: Journal of Medicinal Chemistry. 58:9663-9679
مصطلحات موضوعية: Blood Glucose, Male, Models, Molecular, Cytoplasm, Stereochemistry, Active Transport, Cell Nucleus, Molecular Conformation, Stereoisomerism, Thiophenes, Plasma protein binding, Crystallography, X-Ray, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Glucokinase, Drug Discovery, medicine, Animals, Hypoglycemic Agents, Structure–activity relationship, Lone pair, Adaptor Proteins, Signal Transducing, Cell Nucleus, Sulfonamides, Glucokinase regulatory protein, biology, Chemistry, medicine.anatomical_structure, Microsomes, Liver, biology.protein, Molecular Medicine, Nucleus, Lead compound, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c946578bf834df571e0f47d51f90f41Test
https://doi.org/10.1021/acs.jmedchem.5b01367Test -
2
المؤلفون: Kevin Yang, Rod Cupples, Gwyneth Van, Nobuko Nishimura, Longbin Liu, David J. St. Jean, Clarence Hale, Glenn Sivits, Jie Chen, Nuria A. Tamayo, Steven R. Jordan, Fang-Tsao Hong, Mark H. Norman, Michael D. Bartberger, Yunxin Bo, Christopher H. Fotsch, Samer Chmait, Seifu Tadesse, David Lloyd
المصدر: Journal of Medicinal Chemistry. 58:4462-4482
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Molecular Conformation, Aminopyridines, Crystallography, X-Ray, Sulfone, Rats, Sprague-Dawley, Small Molecule Libraries, Structure-Activity Relationship, chemistry.chemical_compound, Glucokinase, Drug Discovery, Animals, Hypoglycemic Agents, Structure–activity relationship, Glucose homeostasis, Sulfones, Thiazole, Molecular Structure, Glucokinase regulatory protein, biology, Aryl, Small molecule, Rats, Glucose, Liver, chemistry, Biochemistry, biology.protein, Molecular Medicine, Carrier Proteins
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0067ff276fb22038ac064d47a32d35c8Test
https://doi.org/10.1021/jm5018175Test -
3
المؤلفون: Kate S, Ashton, Kristin L, Andrews, Marian C, Bryan, Marion C, Bryan, Jie, Chen, Kui, Chen, Michelle, Chen, Samer, Chmait, Michael, Croghan, Rod, Cupples, Christopher, Fotsch, Joan, Helmering, Steve R, Jordan, Robert J M, Kurzeja, Klaus, Michelsen, Lewis D, Pennington, Steve F, Poon, Glenn, Sivits, Gwyneth, Van, Steve L, Vonderfecht, Robert C, Wahl, Jiandong, Zhang, David J, Lloyd, Clarence, Hale, David J, St Jean
المصدر: Journal of Medicinal Chemistry. 57:309-324
مصطلحات موضوعية: Protein Conformation, Endogeny, Hypoglycemia, Crystallography, X-Ray, Piperazines, Structure-Activity Relationship, In vivo, Glucokinase, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, chemistry.chemical_classification, Sulfonamides, Binding Sites, Glucokinase regulatory protein, biology, Stereoisomerism, medicine.disease, Small molecule, High-Throughput Screening Assays, Rats, Rats, Zucker, Cell biology, Protein Transport, Cytosol, Enzyme, Biochemistry, chemistry, Hepatocytes, biology.protein, Molecular Medicine, Carrier Proteins
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688eef24bebd019f68813ef22be87641Test
https://doi.org/10.1021/jm4016735Test -
4
المؤلفون: Clarence Hale, Martin Henriksson, Randall W. Hungate, Renee Komorowski, Kyung H. Gahm, Jiandong Zhang, Murielle M. Véniant, Janan Jona, Vivian S. W. Li, Andrew Hague, Maurice Emery, Christopher H. Fotsch, Steven R. Jordan, Smriti Joseph, David J. St. Jean, Lars Johansson, Minghan Wang, Rashid Syed, Jeffrey Adams, George A. Moniz, Rod Cupples, Ki Won Kim, Michael D. Bartberger, Jerk Vallgarda, Michelle Chen, Meredith Williams
المصدر: Journal of Medicinal Chemistry. 53:4481-4487
مصطلحات موضوعية: biology, Bicyclic molecule, Stereochemistry, Chemistry, Insulin, medicine.medical_treatment, Diastereomer, In vitro, 11β-hydroxysteroid dehydrogenase type 1, In vivo, Drug Discovery, biology.protein, medicine, Molecular Medicine, Epimer, Isopropyl
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fe379e52733a44c74ee775e8c1cbc9eeTest
https://doi.org/10.1021/jm100242dTest -
5
المؤلفون: Haoda Xu, Michelle Chen, David J. St. Jean, Guy Matsumoto, Zhulun Wang, Christopher H. Fotsch, Minghan Wang, Rod Cupples, Jocelyn McCormick, Clarence Hale, Athena Sudom, Xiaoshan Min, Dean Hickman, Murielle M. Véniant
المصدر: Chemical Biology & Drug Design. 71:36-44
مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Chinese hamster ovary cell, Organic Chemistry, Dehydrogenase, Biology, Biochemistry, chemistry.chemical_compound, Enzyme, Protein structure, chemistry, In vivo, Oxidoreductase, Drug Discovery, Molecular Medicine, Nicotinamide adenine dinucleotide phosphate, Ex vivo
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e0876c60b8c4a81905a37b1e6b541be5Test
https://doi.org/10.1111/j.1747-0285.2007.00603.xTest -
6
المؤلفون: Maurice Emery, Rod Cupples, David J. St. Jean, George A. Moniz, David Pyring, Randall W. Hungate, Chester Chenguang Yuan, Lars Johansson, Aiwen Li, Michelle Chen, Qingyian Liu, Meredith Williams, Steven R. Jordan, Lynn Cai, Lars Tedenborg, Minghan Wang, Christopher H. Fotsch, Nianhe Han, Michael D. Bartberger, Jiandong Zhang, Clarence Hale, Yaxiong Sun, Ben C. Askew
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:6056-6061
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, CHO Cells, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Cricetulus, Cricetinae, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, Aromatic amine, Active site, Fluorine, Human serum albumin, Rats, Thiazoles, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Chlorine, Isopropyl, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8d25f328bd44fee90e85b156177adfTest
https://doi.org/10.1016/j.bmcl.2007.09.070Test -
7
المؤلفون: Jie Chen, Seifu Tadesse, Glenn Sivits, Samer Chmait, David J. St. Jean, Christopher H. Fotsch, Fang-Tsao Hong, Steven R. Jordan, David Lloyd, Michael D. Bartberger, Kate Ashton, Rod Cupples, Mark H. Norman, Clarence Hale
المصدر: Journal of medicinal chemistry. 57(14)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Pyridines, Molecular Conformation, Ring (chemistry), Crystallography, X-Ray, Piperazines, Small Molecule Libraries, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, Glucokinase, Moiety, Structure–activity relationship, Humans, Binding Sites, Glucokinase regulatory protein, biology, Dose-Response Relationship, Drug, Chemistry, Small molecule, Piperazine, Biochemistry, biology.protein, Molecular Medicine, Carrier Proteins, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0bc78dfa951240b6ecb3693e888331bTest
https://pubmed.ncbi.nlm.nih.gov/25001129Test -
8
المؤلفون: Mark H. Norman, Nobuko Nishimura, Samer Chmait, Rod Cupples, Kate Ashton, Roxanne Kunz, Joan Helmering, Aaron C. Siegmund, David J. St. Jean, Clarence Hale, David Lloyd, Steven R. Jordan, Glenn Sivits, Michael D. Bartberger, Christopher H. Fotsch, Kevin Yang, Steve F. Poon, Lewis D. Pennington, Longbin Liu, Jie Chen
المصدر: Journal of medicinal chemistry. 57(7)
مصطلحات موضوعية: Blood Glucose, Models, Molecular, Stereochemistry, Biological Availability, Stereoisomerism, Crystallography, X-Ray, Piperazines, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Discovery, Glucokinase, Diabetes Mellitus, Structure–activity relationship, Animals, Hypoglycemic Agents, Sulfonyl, chemistry.chemical_classification, Sulfonamides, Glucokinase regulatory protein, biology, Aryl, Small molecule, Rats, Disease Models, Animal, chemistry, Biochemistry, Microsome, biology.protein, Hepatocytes, Microsomes, Liver, Molecular Medicine, Carrier Proteins
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9e58eb1815a689eef7dd774dd416f8Test
https://pubmed.ncbi.nlm.nih.gov/24611879Test -
9
المؤلفون: Joan Helmering, Fang-Tsao Hong, Mark H. Norman, Jiandong Zhang, Klaus Michelsen, Markian Stec, Nobuko Nishimura, Steven R. Jordan, Lewis D. Pennington, Rod Cupples, David J. St. Jean, Darren L. Reid, Clarence Hale, Gwyneth Van, Jie Chen, Seifu Tadesse, Roxanne Kunz, Nuria A. Tamayo, Steve F. Poon, Kevin Yang, Christopher H. Fotsch, Longbin Liu, David Lloyd, Glenn Sivits, Elizabeth J. Galbreath, Michael D. Bartberger, Kate Ashton, Samer Chmait
المصدر: Journal of medicinal chemistry. 57(2)
مصطلحات موضوعية: Drug, Blood Glucose, Models, Molecular, media_common.quotation_subject, Metabolite, Morpholines, Pharmacology, Piperazines, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, Drug Discovery, Glucokinase, Potency, Animals, Humans, Hypoglycemic Agents, media_common, Sulfonamides, Glucokinase regulatory protein, biology, Chemistry, Stereoisomerism, Small molecule, In vitro, Rats, Protein Transport, Biochemistry, Alkynes, biology.protein, Hepatocytes, Microsomes, Liver, Molecular Medicine, Carrier Proteins, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d2a8943c3198375b234ab664a4fed0Test
https://pubmed.ncbi.nlm.nih.gov/24405213Test -
10
المؤلفون: Tadashi Yamamoto, Shigeo Mori, Duanzhi Wen, Rod Cupples, Nathan Bucay, Tsutomu Arakawa, Jiro Fujimoto, Barry J. Ratzkin, Toshinori Iwahara
المصدر: Oncogene. 14:439-449
مصطلحات موضوعية: Male, Cancer Research, DNA, Complementary, Recombinant Fusion Proteins, Molecular Sequence Data, Gene Expression, In situ hybridization, Biology, Translocation, Genetic, Receptor tyrosine kinase, Fusion gene, Mice, hemic and lymphatic diseases, Testis, Gene expression, Genetics, Animals, Humans, Anaplastic lymphoma kinase, Anaplastic Lymphoma Kinase, Amino Acid Sequence, Cloning, Molecular, Molecular Biology, Gene, In Situ Hybridization, Gene Library, Neurons, Messenger RNA, Base Sequence, Sequence Homology, Amino Acid, Oncogene, Brain, Nuclear Proteins, Receptor Protein-Tyrosine Kinases, Protein-Tyrosine Kinases, Embryo, Mammalian, Molecular biology, Animals, Newborn, Spinal Cord, Organ Specificity, Chromosomes, Human, Pair 2, biology.protein, Chromosomes, Human, Pair 5, Ganglia, Nucleophosmin
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fba8a50dbdeac596fd316fa112ddebdTest
https://doi.org/10.1038/sj.onc.1200849Test