المؤلفون: Kivelä, Milla Riikka, Bry, Maija, Robciuc, Marius R., Räsänen, Markus, Taavitsainen, Miia, Silvola, Johanna M. U., Saraste, Antti, Hulmi, Juha J., Anisimov, Andrey, Mayranpaa, Mikko I., Lindeman, Jan H., Eklund, Lauri, Hellberg, Sanna, Hlushchuk, Ruslan, Zhuang, Zhen W., Simons, Michael, Djonov, Valentin, Knuuti, Juhani, Mervaala, Eero, Alitalo, Kari

المساهمون: Translational Cancer Biology (TCB) Research Programme, Research Programs Unit, Haartman Institute (-2014), Department of Pathology, Clinicum, Medicum, Department of Pharmacology

مصطلحات موضوعية: endothelial cell, angiogenesis, ischemia, VEGF-B, metabolism, FATTY-ACID UPTAKE, MOUSE HEART, MYOCARDIAL HYPERTROPHY, REPERFUSION INJURY, CARDIAC-FUNCTION, MICE, FAILURE, CONTRIBUTES, ARTERIOGENESIS, 3111 Biomedicine, 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: Petri Kovanen, MD, PhD, Tanja Holopainen, MD, Veli-Matti Leppanen, PhD, Aake Honkaniemi, MSc, Miikka Tarkia, MSc, Ove Eriksson, PhD, Raija Soininen PhD, Matti Jauhiainen, PhD and Thomas Quertermous, MD are acknowledged for their valuable help in the analyses and for providing reagents, and Seppo Yla-Herttuala, MD, PhD for scientific discussions. Stephen Gardell, PhD, Christopher Petucci, PhD and Daniel Kelly, MD, PhD, at the Sanford-Burnham Institute in Orlando are acknowledged for their help and expertise in the Malonyl-CoA analysis. Tapio Tainola, Katja Salo, Laura Raitanen, Kirsi Lintula and Paivi Leinikka are acknowledged for expert technical assistance. We also thank the Biomedicum Imaging Unit for microscope support and the AAV Gene Transfer and Cell Therapy Core Facility of Biocentrum Finland for the viral vectors. The Academy of Finland, European Research Council (ERC-2010-AdG-268804), the Leducq Foundation (11CVD03), Sigrid Juselius Foundation and the Finnish Foundation for Cardiovascular Research are acknowledged for funding. M.B. has been personally supported by grants from the Biomedicum Helsinki Foundation, the Finnish Cultural Foundation, the Maud Kuistila Memorial Foundation, Finnish Cancer Foundation, Orion-Farmos Research Foundation, and the Aarne and Aili Turunen Foundation.; Kivelä , M R , Bry , M , Robciuc , M R , Räsänen , M , Taavitsainen , M , Silvola , J M U , Saraste , A , Hulmi , J J , Anisimov , A , Mayranpaa , M I , Lindeman , J H , Eklund , L , Hellberg , S , Hlushchuk , R , Zhuang , Z W , Simons , M , Djonov , V , Knuuti , J , Mervaala , E & Alitalo , K 2014 , ' VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart ' , EMBO molecular medicine , vol. 6 , no. 3 , pp. 307-321 . https://doi.org/10.1002/emmm.201303147Test; ORCID: /0000-0002-2686-8890/work/29321340; ORCID: /0000-0002-0877-9640/work/32728797; 84895734499; 2a01759e-55e0-4eb4-9928-02f46ce04d2a; http://hdl.handle.net/10138/232588Test; 000332389500003

الإتاحة: http://hdl.handle.net/10138/232588Test

المؤلفون: Karaman, Sinem, Hollmen, Maija, Robciuc, Marius R., Alitalo, Annamari, Nurmi, Harri, Morf, Bettina, Buschle, Dorina, Alkan, H. Furkan, Ochsenbein, Alexandra M., Alitalo, Kari, Wolfrum, Christian, Detmar, Michael

المساهمون: Research Programs Unit, Translational Cancer Biology (TCB) Research Programme, Kari Alitalo / Principal Investigator, Institute for Molecular Medicine Finland, Clinicum

مصطلحات موضوعية: Vegfc, Obesity, Adipose tissue, Inflammation, Macrophages, INSULIN-RESISTANCE, MACROPHAGE POLARIZATION, SKIN CARCINOGENESIS, T-CELLS, LYMPHANGIOGENESIS, ACTIVATION, PREADIPOCYTES, ADIPOGENESIS, RECRUITMENT, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: Karaman , S , Hollmen , M , Robciuc , M R , Alitalo , A , Nurmi , H , Morf , B , Buschle , D , Alkan , H F , Ochsenbein , A M , Alitalo , K , Wolfrum , C & Detmar , M 2015 , ' Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet ' , Molecular metabolism , vol. 4 , no. 2 , pp. 93-105 . https://doi.org/10.1016/j.molmet.2014.11.006Test; ORCID: /0000-0002-0719-1773/work/54151483; ORCID: /0000-0003-3173-1474/work/99597711; 84921848567; 68e2ed10-7c6b-4466-b89e-a9a105985f8c; http://hdl.handle.net/10138/175977Test; 000367432800005

الإتاحة: http://hdl.handle.net/10138/175977Test

المؤلفون: Robciuc, Marius R., Tahvanainen, Esa, Jauhiainen, Matti, Ehnholm, Christian

المساهمون: Department of Medical and Clinical Genetics, Institute for Molecular Medicine Finland

مصطلحات موضوعية: ELISA, lipoproteins, triacylglycerols, high density lipoproteins, body weight, body mass index, serum lipids, post-heparin plasma, HIGH-DENSITY LIPOPROTEIN, INDUCED ADIPOSE FACTOR, FATTY-ACIDS, LIPASE, METABOLISM, HDL, HYPERLIPIDEMIA, TRIGLYCERIDE, ANGPTL3, HUMANS

وصف الملف: application/pdf

العلاقة: Robciuc , M R , Tahvanainen , E , Jauhiainen , M & Ehnholm , C 2010 , ' Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample ' , Journal of Lipid Research , vol. 51 , pp. 824-831 . https://doi.org/10.1194/jlr.M002618Test; 77950613841; 0c7bbb88-58a7-47d6-9c38-f89e165fe2b5; http://hdl.handle.net/10138/162186Test; 000275368800016

الإتاحة: http://hdl.handle.net/10138/162186Test

المؤلفون: Nurmi, Harri, Saharinen, Pipsa, Zarkada, Georgia, Zheng, Wei, Robciuc, Marius R., Alitalo, Kari

المساهمون: Research Programs Unit, Kari Alitalo / Principal Investigator, Translational Cancer Biology (TCB) Research Programme, Pipsa Ilona Saharinen / Principal Investigator

مصطلحات موضوعية: cholesterol, lipid absorption, lymphatic vasculature, obesity, VEGF-C, GROWTH-FACTOR-C, ULTRASTRUCTURAL ANALYSIS, FACTOR RECEPTOR-3, MOUSE EMBRYOS, BLOOD, CELLS, RAT, LYMPHANGIOGENESIS, VASCULATURE, FAILURE, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: We thank Jarmo Koponen, Essi Salminen, Maija Atuegwu, Mari Jokinen, Tapio Tainola, and Kirsi Manttari for technical assistance, the personnel of the Biomedicum Imaging Unit for microscopy service and the Laboratory Animal Center of the University of Helsinki for animal housing. This study was supported in part by the Leducq Transatlantic Network of Excellence in Lymph Vessels in Obesity and Cardiovascular Disease (grant no: 11CVD03), the Marie Curie ITN Vessel consortium (grant no: 317250) of the Seventh Framework Program of European Union, Academy of Finland Centre of Excellence in Translational Cancer Biology 2014-2019 (grant no: 271845), the European Research Council (ERC-2010-AdG-268804); the Finnish Cancer Research Organizations, the Sigrid Juselius Foundation, and by the Biomedicum Helsinki Foundation and Ida Montin Foundation (to H.N.).; Nurmi , H , Saharinen , P , Zarkada , G , Zheng , W , Robciuc , M R & Alitalo , K 2015 , ' VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption ' , EMBO molecular medicine , vol. 7 , no. 11 , pp. 1418-1425 . https://doi.org/10.15252/emmm.201505731Test; ORCID: /0000-0003-3173-1474/work/99597727; 84946478463; 9e0bdf6c-7a7b-4e37-948d-83ed5d0a7f26; http://hdl.handle.net/10138/161934Test; 000364320100004

الإتاحة: http://hdl.handle.net/10138/161934Test

المؤلفون: Robciuc, Marius R., Naukkarinen, Jussi, Ortega-Alonso, Alfredo, Tyynismaa, Henna, Raivio, Taneli, Rissanen, Aila, Kaprio, Jaakko, Ehnholm, Christian, Jauhiainen, Matti, Pietiläinen, Kirsi Hannele

المساهمون: Institute for Molecular Medicine Finland, Department of Medicine, Department of Psychiatry, Hjelt Institute (-2014), Department of Public Health, Research Programme for Molecular Neurology, Medicum, Department of Physiology, Children's Hospital, Clinicum, Raivio Group, HUS Children and Adolescents, HUS Psychiatry, HUS Internal Medicine and Rehabilitation, Genetic Epidemiology

مصطلحات موضوعية: Angptl4, heritability, twin pairs, obesity-discordant monozygotic twins, FREE FATTY-ACIDS, TARGET GENE, PLASMA, ANGIOGENESIS, METASTASIS, INHIBITION, METABOLISM, RESISTANCE, LIPOLYSIS, TUMORS, 3142 Public health care science, environmental and occupational health

وصف الملف: application/pdf

العلاقة: Robciuc , M R , Naukkarinen , J , Ortega-Alonso , A , Tyynismaa , H , Raivio , T , Rissanen , A , Kaprio , J , Ehnholm , C , Jauhiainen , M & Pietiläinen , K H 2011 , ' Serum angiopoietin-like 4 protein levels and expression in adipose tissue are inversely correlated with obesity in monozygotic twins ' , Journal of Lipid Research , vol. 52 , no. 8 , pp. 1575-1582 . https://doi.org/10.1194/jlr.P015867Test; ORCID: /0000-0002-2493-2422/work/29948444; 79960689146; a40dcdc9-f4cd-488b-b377-98709a0c9cb1; http://hdl.handle.net/10138/162187Test; 000292763200016

الإتاحة: http://hdl.handle.net/10138/162187Test

المؤلفون: Robciuc, Marius R., Metso, Jari, Sima, Anca, Ehnholm, Christian, Jauhiainen, Matti

المساهمون: Institute for Molecular Medicine Finland

مصطلحات موضوعية: PHOSPHOLIPID TRANSFER PROTEIN, HUMAN-PLASMA, ATHEROSCLEROTIC LESIONS, CHOLESTEROL EFFLUX, A-I, DEFICIENCY, SECRETION, BINDING, FORMS, MICE, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: The authors would like to express gratitude to Acad. Maya Simionescu for facilitating this collaborative study and Sari Nuutinen for excellent technical assistance. This study was supported by the Research Council for the Health, Academy of Finland, Grants 114484 and 132629, Ministry for Education, Research, Youth and Sport, Romania, Grant 1220/2008, Finska Lakaresallskape and Magnus Ehrnrooth Foundation.; Robciuc , M R , Metso , J , Sima , A , Ehnholm , C & Jauhiainen , M 2010 , ' Human apoA-I increases macrophage foam cell derived PLTP activity without affecting the PLTP mass ' , Lipids in Health and Disease , vol. 9 , 59 . https://doi.org/10.1186/1476-511X-9-59Test; 77953186494; e89687f1-9cff-493e-9342-f14781e69bf5; http://hdl.handle.net/10138/162280Test; 000279909400001

الإتاحة: http://hdl.handle.net/10138/162280Test

المؤلفون: Robciuc, Marius R., Kivela, Riikka, Williams, Ian M., de Boer, Jan Freark, van Dijk, Theo H., Elamaa, Harri, Tigistu-Sahle, Feven, Molotkov, Dmitry, Leppanen, Veli-Matti, Kakela, Reijo, Eklund, Lauri, Wasserman, David H., Groen, Albert K., Alitalo, Kari

المصدر: Robciuc , M R , Kivela , R , Williams , I M , de Boer , J F , van Dijk , T H , Elamaa , H , Tigistu-Sahle , F , Molotkov , D , Leppanen , V-M , Kakela , R , Eklund , L , Wasserman , D H , Groen , A K & Alitalo , K 2016 , ' VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications ' , Cell metabolism , vol. 23 , no. 4 , pp. 712-724 . https://doi.org/10.1016/j.cmet.2016.03.004Test

مصطلحات موضوعية: ENDOTHELIAL GROWTH-FACTOR, FATTY-ACID UPTAKE, B-DEFICIENT MICE, VEGF-B, INSULIN-RESISTANCE, MYOCARDIAL-INFARCTION, SIGNAL-TRANSDUCTION, ANGIOGENESIS, RATS, INFLAMMATION

العلاقة: https://research.rug.nl/en/publications/f3f040db-8298-425c-9428-acb2ec1e7c5bTest

الإتاحة: https://doi.org/10.1016/j.cmet.2016.03.004Test
https://hdl.handle.net/11370/f3f040db-8298-425c-9428-acb2ec1e7c5bTest
https://research.rug.nl/en/publications/f3f040db-8298-425c-9428-acb2ec1e7c5bTest

المؤلفون: Aspelund, Aleksanteri, Robciuc, Marius R., Karaman, Sinem, Makinen, Taija, Alitalo, Kari

المصدر: Circulation Research ; volume 118, issue 3, page 515-530 ; ISSN 0009-7330 1524-4571

الإتاحة: https://doi.org/10.1161/circresaha.115.306544Test

المؤلفون: Karaman, Sinem, Hollmèn, Maija, Robciuc, Marius R., Alitalo, Annamari, Nurmi, Harri, Morf, Bettina, Buschle, Dorina, Alkan, Hamza Furkan, Ochsenbein, Alexandra M., Alitalo, Kari, Wolfrum, Christian, Detmar, Michael

وصف الملف: application/pdf

العلاقة: http://openlib.tugraz.at/5d66fd2df27cdTest

الإتاحة: http://openlib.tugraz.at/5d66fd2df27cdTest

المؤلفون: Nurmi, Harri, Saharinen, Pipsa, Zarkada, Georgia, Zheng, Wei, Robciuc, Marius R, Alitalo, Kari

المصدر: EMBO Molecular Medicine ; volume 7, issue 11, page 1418-1425 ; ISSN 1757-4676 1757-4684

مصطلحات موضوعية: Molecular Medicine

الإتاحة: https://doi.org/10.15252/emmm.201505731Test