دورية أكاديمية
Trans ethosomal hybrid composites of naproxen-sulfapyridine in hydrogel carrier: anti-inflammatory response in complete Freund’s adjuvant induced arthritis rats
| العنوان: | Trans ethosomal hybrid composites of naproxen-sulfapyridine in hydrogel carrier: anti-inflammatory response in complete Freund’s adjuvant induced arthritis rats |
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| المؤلفون: | Sajeev Kumar Babasahib, Roaddy Well Born, Nulgumnalli Manjunathaiah Raghavendra |
| المصدر: | Artificial Cells, Nanomedicine, and Biotechnology, Vol 50, Iss 1, Pp 59-70 (2022) |
| بيانات النشر: | Taylor & Francis Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biotechnology LCC:Medical technology |
| مصطلحات موضوعية: | Nanohydrogel, ethosome, rheumatoid arthritis, DMARDs, NSAIDs, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | AbstractCurrent treatment for Rheumatoid arthritis (RA) utilizes Disease-modifying antirheumatic drugs, non-steroidal anti-inflammatory drugs or its combination, to decrease joint inflammation. In the present study, naproxen (NAP) and sulfapyridine (SULF) ethosomes were prepared by a thin-film hydration technique using PL90G and cholesterol, later crosslinked with carbopol®934. The ethosomes and ethosomal hydrogel were evaluated for rheological properties, physico-chemical analysis, in vitro and in vivo study. The results show, NAP and SULF ethosomes exhibited an average vesicle size between 251.1 ± 1.80–343.5 ± 3.23 nm and 269.0 ± 1.17–358.8 ± 1.22 nm, respectively, with good stability (zeta potential > 30 mV) and polydispersity index. Differential scanning calorimeter and Fourier transform infrared studies reveal no significant changes in the drug properties of ethosomes. Transmission electron microscopy analysis discloses spherical shape vesicles below 200 nm. The entrapment efficiency of NAP and SULF ethosomes was above 66%, and NAP-SULF ethosomes-hydrogel (EH) exhibited a sustained release effect (>8 h). In vivo studies on NAP-SULF EH shows significant inhibition of inflammation (84.63%), with less paw volume (0.1935 ± 0.08 ml) on induced arthritis Albino Wistar rats, (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 21691401 2169-141X 2169-1401 |
| العلاقة: | https://doaj.org/toc/2169-1401Test; https://doaj.org/toc/2169-141XTest |
| DOI: | 10.1080/21691401.2022.2047712 |
| الوصول الحر: | https://doaj.org/article/8a1dcadccf15487a8bcb74844be144ccTest |
| رقم الانضمام: | edsdoj.8a1dcadccf15487a8bcb74844be144cc |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 21691401 2169141X |
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| DOI: | 10.1080/21691401.2022.2047712 |