The Effect of Renin Angiotensin System Genetic Variants in Acute Pancreatitis
| العنوان: | The Effect of Renin Angiotensin System Genetic Variants in Acute Pancreatitis |
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| المؤلفون: | Hans-Ulrich Schulz, James R. A. Skipworth, Hugh Montgomery, Jay Acharya, Steven W.M. Olde Damink, Hjalmar C. van Santvoort, Mika Kivimäki, Meena Kumari, Jackie A. Cooper, Marc G. Besselink, Massimo Malagó, Rm. Nijmeijer, Arjun Shankar, Steve E. Humphries |
| المساهمون: | Surgery, RS: NUTRIM - R2 - Gut-liver homeostasis, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam |
| المصدر: | Annals of Surgery, 261(1), 180-188. LIPPINCOTT WILLIAMS & WILKINS Annals of surgery, 261(1), 180-188. Lippincott Williams and Wilkins |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Vitamin, medicine.medical_specialty, Adolescent, Genotype, Pancreatitis, Alcoholic, Peptidyl-Dipeptidase A, Polymorphism, Single Nucleotide, Article, Renin-Angiotensin System, Young Adult, chemistry.chemical_compound, Internal medicine, Renin, Renin–angiotensin system, medicine, Vitamin D and neurology, Humans, Vitamin D, Allele, Aged, Aged, 80 and over, Angiotensin II receptor type 1, business.industry, Middle Aged, medicine.disease, Angiotensin II, Endocrinology, Pancreatitis, chemistry, Acute Disease, Acute pancreatitis, Female, Surgery, business |
| الوصف: | Objectives: We sought association of genetic variants in the renin-angiotensin system (RAS) and vitamin D system with acute pancreatitis (AP) development and severity. Background: The endocrine RAS is involved in circulatory homeostasis through the pressor action of angiotensin II at its AT1 receptor. However, local RAS regulate growth and inflammation in diverse cells and tissues, and their activity may be suppressed by vitamin D. Intrapancreatic angiotensin II generation has been implicated in the development of AP. Methods: Five hundred forty-four white patients with AP from 3 countries (United Kingdom, 22; Germany, 136; and The Netherlands 386) and 8487 control subjects (United Kingdom 7833, The Netherlands 717) were genotyped for 8 polymorphisms of the RAS/vitamin D systems, chosen on the basis of likely functionality. Results: The angiotensin-converting enzyme I (rather than D) allele was significantly associated with alcohol-related AP when all cohorts were combined (P = 0.03). The renin rs5707 G (rather than A) allele was associated with AP (P = 0.002), infected necrosis (P = 0.025) and mortality (P = 0.046). Conclusions: The association of 2 RAS polymorphisms with AP suggests the need for further detailed analysis of the role of RAS/vitamin D in the genesis or severity of AP, particularly given the ready potential for pharmacological manipulation of this system using existing marketed agents. However, further replication studies will be required before any such association is considered robust, particularly given the significant heterogeneity of AP causation and clinical course. |
| تدمد: | 0003-4932 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0c036e4dd2788a922e8d58ea5ca108Test https://doi.org/10.1097/sla.0000000000000655Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7e0c036e4dd2788a922e8d58ea5ca108 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00034932 |
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