Physician and Patient Barriers to Breast Cancer Preventive Therapy
| العنوان: | Physician and Patient Barriers to Breast Cancer Preventive Therapy |
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| المؤلفون: | Ruth Heisey, Sandhya Pruthi, Melinda Wu, Susan Hum |
| المصدر: | Current Breast Cancer Reports |
| بيانات النشر: | Springer US, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | medicine.medical_specialty, AIs, Psychological intervention, Uptake, Chemoprevention, law.invention, Efficacy, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Randomized controlled trial, law, Primary prevention, medicine, 030212 general & internal medicine, Intensive care medicine, Gynecology, business.industry, medicine.disease, Preventive therapy, Aromatase inhibitors, Oncology, 030220 oncology & carcinogenesis, Risk and Prevention (TB Bevers, Section Editor), business, Risk assessment, Selective estrogen receptor modulators, Clinical risk factor, SERMs, Decision-making |
| الوصف: | The uptake of selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs) for the primary prevention of breast cancer is low, despite their proven efficacy in several randomized clinical trials. This review summarizes the latest data on physicians’ and women’s barriers to breast cancer preventive therapy. Physicians’ challenges include: identifying suitable candidates for preventive therapy, inadequate training and confidence in risk assessment and counselling, insufficient knowledge of risk-reducing medications, and lack of time. High-risk women fear medication side effects, and they often weigh experiences of others more heavily than statistical probabilities to guide their decision-making. Despite decision aid interventions to help women make an informed decision, acceptance of preventive therapy will remain low until: risk/benefit profiles are more favorable, physicians are better educated and skilled in having these discussions, and suitable biomarkers to monitor drug efficacy and better clinical risk prediction models to assess true individual risk are available. |
| اللغة: | English |
| تدمد: | 1943-4596 1943-4588 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbba2640afc03eed8af5fdf506bcfddbTest http://europepmc.org/articles/PMC4995234Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cbba2640afc03eed8af5fdf506bcfddb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19434596 19434588 |
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