دورية أكاديمية
Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the 'European Human Biomonitoring Initiative' HBM4EU participating studies
| العنوان: | Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the 'European Human Biomonitoring Initiative' HBM4EU participating studies |
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| المؤلفون: | Fernández, Sandra F., Poteser, Michel, Govarts, Eva, Pardo, Olga, Coscollà, Clara, Schettgen, Thomas, Vogel, Nina, Weber, Till, Murawski, Aline, Kolossa‐Gehring, Marike, Rüther, Maria, Schmidt, Phillipp, Namorado, Sónia, Van Nieuwenhuyse, An, Appenzeller, Brice, Ólafsdóttir, Kristín, Halldorsson, Thorhallur I., Haug. Line S, Thomsen, Cathrine, Barbone, Fabio, Mariuz, Marika, Rosolen, Valentina, Rambaud, Loic, Rio, Margaux, Göen, Thomas, Nübler, Stefanie, Schäfer, Moritz, Zarrabi, Karin H. A., Sepal, Ovnair, Rodriguez Martin, Laura, Schoeters, Greet, Gilles, Liese, Leander, Karin, Moshammer, Hanns, Akesson, Agneta, Federica, Laguzzi |
| المصدر: | Fernández, Sandra F. Poteser, Michel Govarts, Eva Pardo, Olga Coscollà, Clara Schettgen, Thomas Vogel, Nina Weber, Till Murawski, Aline Kolossa‐Gehring, Marike Rüther, Maria Schmidt, Phillipp Namorado, Sónia Van Nieuwenhuyse, An Appenzeller, Brice Ólafsdóttir, Kristín Halldorsson, Thorhallur I. Haug. Line S Thomsen, Cathrine Barbone, Fabio Mariuz, Marika Rosolen, Valentina Rambaud, Loic Rio, Margaux Göen, Thomas Nübler, Stefanie Schäfer, Moritz Zarrabi, Karin H. A. Sepal, Ovnair Rodriguez Martin, Laura Schoeters, Greet Gilles, Liese Leander, Karin Moshammer, Hanns Akesson, Agneta Federica, Laguzzi 2023 Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the 'European Human .... |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2024 |
| المجموعة: | Universitat de València: Roderic - Repositorio de contenido libre |
| مصطلحات موضوعية: | UNESCO::QUÍMICA |
| الوصف: | Little is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed determinants of AA exposure, measured by urinary mercapturic acids of AA (AAMA) and glycidamide (GAMA), its main metabolite, in 3157 children/adolescents and 1297 adults in the European Human Biomonitoring Initiative. Harmonized individual-level questionnaires data and quality assured measurements of AAMA and GAMA (urine collection: 2014-2021), the short-term validated biomarkers of AA exposure, were obtained from four studies (Italy, France, Germany, and Norway) in children/adolescents (age range: 3-18 years) and six studies (Portugal, Spain, France, Germany, Luxembourg, and Iceland) in adults (age range: 20-45 years). Multivariable-adjusted pooled quantile regressions were employed to assess median differences (β coefficients) with 95% confidence intervals (95% CI) in AAMA and GAMA (µg/g creatinine) in relation to exposure determinants. Southern European studies had higher AAMA than Northern studies. In children/adolescents, we observed significant lower AA associated with high socioeconomic status (AAMA:β = − 9.1 µg/g creatinine, 95% CI − 15.8, − 2.4; GAMA: β = − 3.4 µg/g creatinine, 95% CI − 4.7, − 2.2), living in rural areas (AAMA:β = − 4.7 µg/g creatinine, 95% CI − 8.6, − 0.8; GAMA:β = − 1.1 µg/g creatinine, 95% CI − 1.9, − 0.4) and increasing age (AAMA:β = − 1.9 µg/g creatinine, 95% CI − 2.4, − 1.4; GAMA:β = − 0.7 µg/g creatinine, 95% CI − 0.8, − 0.6). In adults, higher AAMA was also associated with high consumption of fried potatoes whereas lower AAMA was associated with higher body-mass-index. Based on this large-scale study, several potential determinants of AA exposure were identified in children/adolescents and adults in European countries. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | Scientific Reports, 2023, vol. 13, p. 21291; F. Fernández, S., Poteser, M., Govarts, E., Pardo, O., Coscollà, C., Schettgen, T., Vogel, N., Weber, T., Murawski, A., Kolossa-Gehring, M., Rüther, M., Schmidt, P., Namorado, S., Van Nieuwenhuyse, A., Appenzeller, B., Ólafsdóttir, K., Halldorsson, T. I., Haug, L. S., Thomsen, C., … Federica, L. (2023). Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the “European Human Biomonitoring Initiative” HBM4EU participating studies. En Scientific Reports (Vol. 13, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1038/s41598-023-48738-6Test; https://hdl.handle.net/10550/92677Test; 162675 |
| DOI: | 10.1038/s41598-023-48738-6 |
| الإتاحة: | https://doi.org/10.1038/s41598-023-48738-6Test https://hdl.handle.net/10550/92677Test |
| حقوق: | open access |
| رقم الانضمام: | edsbas.A160BA4C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-023-48738-6 |