دورية أكاديمية
Effect of genetic variants associated with plasma homocysteine levels on stroke risk
| العنوان: | Effect of genetic variants associated with plasma homocysteine levels on stroke risk |
|---|---|
| المؤلفون: | Cotlarciuc, I. (Ioana), Malik, R. (Rainer), Holliday, E.G. (Elizabeth), Ahmadi, K.R. (Kourosh), Paré, G. (Guillaume), Psaty, B.M. (Bruce), Fornage, M. (Myriam), Hasan, N. (Nazeeha), Rinne, P.E. (Paul), Ikram, M.A. (Arfan), Markus, H.S. (Hugh), Rosand, J. (Jonathan), Mitchell, B.D. (Braxton), Kittner, T. (Thomas), Meschia, J.F. (James F.), Meurs, J.B.J. (Joyce) van, Uitterlinden, A.G. (André), Worrall, B.B. (Bradford B.), Kubisch, C. (Christian), Sharma, P. (Pankaj) |
| المصدر: | Stroke vol. 45 no. 7, pp. 1920-1924 |
| سنة النشر: | 2014 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| مصطلحات موضوعية: | genetic association studies, genetic risk score, homocysteine, stroke |
| الوصف: | BACKGROUND AND PURPOSE - : Elevated total plasma homocysteine (tHcy) levels are known to be associated with increased risk of ischemic stroke (IS). Given that both tHcy and IS are heritable traits, we investigated a potential genetic relationship between homocysteine levels and stroke risk by assessing 18 polymorphisms previously associated with tHcy levels for their association with IS and its subtypes. METHODS - : Previous meta-analysis results from an international stroke collaborative network, METASTROKE, were used to assess association of the 18 tHcy-associated single-nucleotide polymorphisms (SNPs) in 12 389 IS cases and 62 004 controls. We also investigated the associations in regions located within 50 kb from the 18 tHcy-related SNPs and the association of a genetic risk score, including the 18 SNPs. RESULTS - : One SNP located in the RASIP1 gene and a cluster of 3 SNPs located at and near SLC17A3 were significantly associated with IS (P<0.0003) after correcting for multiple testing. For stroke subtypes, the sentinel SNP located upstream of MUT was significantly associated with small-vessel disease (P=0.0022), whereas 1 SNP located in MTHFR was significantly associated with large-vessel dis |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://repub.eur.nl/pub/60572Test; urn:hdl:1765/60572 |
| DOI: | 10.1161/STROKEAHA.114.005208 |
| الإتاحة: | https://doi.org/10.1161/STROKEAHA.114.005208Test http://repub.eur.nl/pub/60572Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.19298D3B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1161/STROKEAHA.114.005208 |
|---|