المؤلفون: Velcicky, Juraj, Bodendorf, Ursula, Rigollier, Pascal, Epple, Robert, Beisner, Daniel R., Guerini, Danilo, Smith, Philip, Liu, Bo, Feifel, Roland, Wipfli, Peter, Aichholz, Reiner, Couttet, Philippe, Dix, Ina, Widmer, Toni, Wen, Ben, Brandl, Trixi

المصدر: Journal of Medicinal Chemistry ; volume 61, issue 3, page 865-880 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.7b01371Test

المؤلفون: Lorthiois, Edwige, Gerspacher, Marc, Beyer, Kim, Vaupel, Andrea, Leblanc, Catherine, Stringer, Rowan, Weiss, Andreas, Wilcken, Rainer, Guthy, Daniel Alexander, Lingel, Andreas, Bomio-Confaglia, Claudio, Machauer, Rainer, Rigollier, Pascal, Ottl, Johannes, Arz, Dorothee, Bernet, Pascal, Desjonqueres, Gaelle, Dussauge, Solene, Kazic-Legueux, Malika, Lozac'h, Marie-Anne, Mura, Christophe, Sorge, Mickael, Todorov, Milen, Warin, Nicolas, Zink, Florence, Voshol, Johannes, Zecri, Frederic, Sedrani, Richard, Ostermann, Nils, Brachmann, Saskia

العلاقة: Lorthiois, Edwige, Gerspacher, Marc, Beyer, Kim, Vaupel, Andrea, Leblanc, Catherine, Stringer, Rowan, Weiss, Andreas, Wilcken, Rainer, Guthy, Daniel Alexander, Lingel, Andreas, Bomio-Confaglia, Claudio, Machauer, Rainer, Rigollier, Pascal, Ottl, Johannes, Arz, Dorothee, Bernet, Pascal, Desjonqueres, Gaelle, Dussauge, Solene, Kazic-Legueux, Malika, Lozac'h, Marie-Anne, Mura, Christophe, Sorge, Mickael, Todorov, Milen, Warin, Nicolas, Zink, Florence, Voshol, Johannes, Zecri, Frederic, Sedrani, Richard, Ostermann, Nils and Brachmann, Saskia (2022) JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors. Journal of medicinal chemistry, 65 (24). pp. 16173-16203. ISSN 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.2c01438Test
https://oak.novartis.com/48106Test/

المؤلفون: Weiss, Andreas, Lorthiois, Edwige, Barys, Louise, Beyer, Kim, Bomio-Confaglia, Claudio, Burks, Heather, Chen, Xueying, Cui, Xiaoming, de Kanter, Ruben, Dharmarajan, Lekshmi, Fedele, Carmine, Gerspacher, Marc, Guthy, Daniel Alexander, Head, Victoria, Jaeger, Ashley, Jimenez Nunez, Eloisa, Kearns, Jeff, Leblanc, Catherine, Maira, Michel, Murphy, Jason, Oakman, Helen, Ostermann, Nils, Ottl, Johannes, Rigollier, Pascal, Roman, Danielle, Schnell, Christian, Sedrani, Richard, Shimizu, Toshio, Stringer, Rowan, Vaupel, Andrea, Voshol, Johannes, Wessels, Peter, Widmer, Toni, Wilcken, Rainer, Xu, Kun, Zecri, Frederic, Farago, Anna, Cotesta, Simona, Brachmann, Saskia

العلاقة: Weiss, Andreas, Lorthiois, Edwige, Barys, Louise, Beyer, Kim, Bomio-Confaglia, Claudio, Burks, Heather, Chen, Xueying, Cui, Xiaoming, de Kanter, Ruben, Dharmarajan, Lekshmi, Fedele, Carmine, Gerspacher, Marc, Guthy, Daniel Alexander, Head, Victoria, Jaeger, Ashley, Jimenez Nunez, Eloisa, Kearns, Jeff, Leblanc, Catherine, Maira, Michel, Murphy, Jason, Oakman, Helen, Ostermann, Nils, Ottl, Johannes, Rigollier, Pascal, Roman, Danielle, Schnell, Christian, Sedrani, Richard, Shimizu, Toshio, Stringer, Rowan, Vaupel, Andrea, Voshol, Johannes, Wessels, Peter, Widmer, Toni, Wilcken, Rainer, Xu, Kun, Zecri, Frederic, Farago, Anna, Cotesta, Simona and Brachmann, Saskia (2022) Discovery, preclinical characterization, and early clinical activity of JDQ443, a structurally novel, highly potent, selective covalent oral inhibitor of KRASG12C. Discovery, preclinical characterization, and early clinical activity of JDQ443, a structurally novel, highly potent, selective covalent oral inhibitor of KRASG12C.

الإتاحة: https://doi.org/10.1158/2159-8290.CD-22-0158Test
https://oak.novartis.com/46756Test/
https://pubmed.ncbi.nlm.nih.gov/35404998Test/

المؤلفون: Lorthiois, Edwige, Gerspacher, Marc, Beyer, Kim S., Vaupel, Andrea, Leblanc, Catherine, Stringer, Rowan, Weiss, Andreas, Wilcken, Rainer, Guthy, Daniel A., Lingel, Andreas, Bomio-Confaglia, Claudio, Machauer, Rainer, Rigollier, Pascal, Ottl, Johannes, Arz, Dorothee, Bernet, Pascal, Desjonqueres, Gaëlle, Dussauge, Solene, Kazic-Legueux, Malika, Lozac'h, Marie-Anne

المصدر: Journal of Medicinal Chemistry; 12/22/2022, Vol. 65 Issue 24, p16173-16203, 31p