التفاصيل البيبلوغرافية
| العنوان: |
FHL-1 is not involved in pressure overload-induced maladaptive right ventricular remodeling and dysfunction |
| المؤلفون: |
Veith, Christine, Neghabian, Dariusch, Luitel, Himal, Wilhelm, Jochen, Egemnazarov, Bakytbek, Muntanjohl, Caja, Fischer, Jan-Hendrik, Dahal, Bhola Kumar, Schermuly, Ralph Theo, Ghofrani, Hossein Ardeschir, Grimminger, Friedrich, Fink, Ludger, Kwapiszewska, Grazyna, Weissmann, Norbert, Sydykov, Akylbek |
| المصدر: |
http://lobid.org/resources/99370671625606441Test#!, 115(2):17. |
| سنة النشر: |
2020 |
| المجموعة: |
Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: |
Ventricular Dysfunction, Right/physiopathology [MeSH], Mice, Inbred C57BL [MeSH], Heart Ventricles/physiopathology [MeSH], Original Contribution, LIM Domain Proteins/deficiency [MeSH], Right/pathology [MeSH], Right/genetics [MeSH], Hypertrophy, Right Ventricular/physiopathology [MeSH], Male [MeSH], Natriuretic Peptides/metabolism [MeSH], Four and-a-half LIM domain 1 protein, Calcium-Binding Proteins/metabolism [MeSH], Ryanodine Receptor Calcium Release Channel/metabolism [MeSH], Muscle Proteins/metabolism [MeSH], Disease Models, Animal [MeSH], LIM Domain Proteins/genetics [MeSH], Muscle Proteins/genetics [MeSH], Cytoskeletal proteins, Intracellular Signaling Peptides and Proteins/metabolism [MeSH], Fibrosis [MeSH], Right Ventricular/metabolism [MeSH], Ventricular Function, Right [MeSH], Intracellular Signaling Peptides and Proteins/deficiency [MeSH], Animals [MeSH], Knockout [MeSH] |
| الوصف: |
Aims!#!The cytoskeletal signaling protein four and-a-half LIM domains 1 (FHL-1) has recently been identified as a novel key player in pulmonary hypertension as well as in left heart diseases. In this regard, FHL-1 has been implicated in dysregulated hypertrophic signaling in pulmonary arterial smooth muscle cells leading to pulmonary hypertension. In mice, FHL-1-deficiency (FHL-1!##!Methods and results!#!We investigated FHL-1 expression in C57Bl/6 mice subjected to chronic biomechanical stress and found it to be enhanced in the right ventricle (RV). Next, we subjected FHL-1!##!Conclusion!#!FHL-1 pathway is not involved in the control of adverse remodeling in the pressure overloaded RV. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| ردمك: |
978-9937-0-6716-4
9937-0-6716-2 |
| العلاقة: |
https://repository.publisso.de/resource/frl:6466416Test; https://doi.org/10.1007/s00395-019-0767-5Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981327Test/ |
| DOI: |
10.1007/s00395-019-0767-5 |
| الإتاحة: |
https://doi.org/10.1007/s00395-019-0767-5Test
https://repository.publisso.de/resource/frl:6466416Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981327Test/ |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.E69B7335 |
| قاعدة البيانات: |
BASE |
