المؤلفون: Buchebner, D, Malmgren, L, Christensson, A, McGuigan, F, Gerdhem, P, Ridderstråle, M, Åkesson, K

المصدر: Journal of the Endocrine Society. 1(6):615-624

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:229264515Test

المؤلفون: Brown, A.A., Giordano, G.N., Ridderstråle, M., Franks, P.W., Atabaki-Pasdar, N., Fitipaldi, H., Groop, L., Klintenberg, M., Pomares-Millan, H., Viñuela, A.

المصدر: Nature Communications EpiHealth: Epidemiology for Health EXODIAB: Excellence of Diabetes Research in Sweden eSSENCE: The e-Science Collaboration. 14

مصطلحات موضوعية: Genomics, Humans, Multifactorial Inheritance, Phenotype, Research Personnel, RNA, Messenger, messenger RNA, plasma protein, protein kinase Lck, transcription factor, blood, gene expression, genetic analysis, phenotype, protein, 5' untranslated region, adult, aged, Article, biochemical analysis, cohort analysis, DNA extraction, donor, exon, fasting blood glucose level, female, functional enrichment analysis, gene linkage disequilibrium, genetic association, genetic heterogeneity, genetic regulation, genetic variation, genome-wide association study, genotyping, human, impaired glucose tolerance, major clinical study, male, mitochondrion, non insulin dependent diabetes mellitus, pancreas islet, phenotypic variation, pleiotropy, proteomics, quantitative trait locus, RNA sequencing, single nucleotide polymorphism, transcription regulation, Y chromosome, genomics, multifactorial inheritance, personnel, Medicin och hälsovetenskap, Medicinska och farmaceutiska grundvetenskaper, Medicinsk genetik, Medical and Health Sciences, Basic Medicine, Medical Genetics

الوصول الحر: https://lup.lub.lu.se/record/7d0a1863-4e00-4890-92a3-4e041a7bc2c0Test
http://dx.doi.org/10.1038/s41467-023-40569-3Test

المؤلفون: Allesøe, R.L., Ridderstråle, M., Giordano, G.N., Franks, P.W., Groop, L., Pasdar, N.A., Fitipaldi, H., Kurbasic, A., Mutie, P., Pomares-Millan, H., Klintenberg, M., Abdalla, M.

المصدر: Nature Biotechnology EXODIAB: Excellence of Diabetes Research in Sweden EpiHealth: Epidemiology for Health eSSENCE: The e-Science Collaboration.

مصطلحات موضوعية: Deep learning, Learning systems, Patient treatment, 'omics', Auto encoders, In-silico, Learning models, Multi-modal data, Multi-modal dataset, Non-trivial tasks, Omics technologies, Phenotyping, Type-2 diabetes, Modal analysis, Medicin och hälsovetenskap, Klinisk medicin, Endokrinologi och diabetes, Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes

الوصول الحر: https://lup.lub.lu.se/record/13c6b992-22aa-4bcc-b353-dbd6f2f72642Test
http://dx.doi.org/10.1038/s41587-022-01520-xTest

المؤلفون: Allesøe, Rosa Lundbye, Lundgaard, A., Hernández Medina, R., Aguayo-Orozco, Alejandro, Johansen, J., Nissen, Jakob Nybo, Brorsson, Caroline, Mazzoni, Gianluca, Niu, L., Biel, J., Leal Rodríguez, C., Brasas, Valentas, Webel, Henry, Benros, M., Pedersen, A., Chmura, Piotr Jaroslaw, Jacobsen, U., Mari, Andrea, Koivula, R., Mahajan, Anubha, Vinuela, A., Tajes, Juan Fernandez, Sharma, Sapna, Haid, M., Hong, M., Musholt, Petra B, De Masi, Federico, Vogt, Josef, Pedersen, Helle Krogh, Gudmundsdottir, Valborg, Jones, Angus, Kennedy, G., Bell, Jimmy, Thomas, E.L., Frost, G., Thomsen, Henrik, Hansen, Elizaveta, Hansen, T., Vestergaard, Henrik, Muilwijk, Mirthe, Blom, Marieke T, 't Hart, Leen M, Pattou, Francois, Raverdy, Violeta, Brage, Soren, Kokkola, Tarja, Heggie, Alison, McEvoy, Donna, Mourby, Miranda, Kaye, J., Hattersley, A., McDonald, Timothy, Ridderstråle, M., Walker, Mark, Forgie, Ian, Giordano, Giuseppe N, Pavo, Imre, Ruetten, Hartmut, Pedersen, O., Dermitzakis, Emmanouil, Franks, Paul W, Schwenk, J., Adamski, Jerzy, McCarthy, Mark I, Pearson, Ewan, Banasik, Karina, Rasmussen, S., Brunak, S., IMI DIRECT Consortium

وصف الملف: application/pdf

العلاقة: https://westminsterresearch.westminster.ac.uk/download/9810d123e49a8ab66192883b3052cbe38c8896bc716f413c75645bc63d032dcf/502186/s41587-023-01805-9-1.pdfTest; https://doi.org/10.1038/s41587-023-01805-9Test; Allesøe, Rosa Lundbye, Lundgaard, A., Hernández Medina, R., Aguayo-Orozco, Alejandro, Johansen, J., Nissen, Jakob Nybo, Brorsson, Caroline, Mazzoni, Gianluca, Niu, L., Biel, J., Leal Rodríguez, C., Brasas, Valentas, Webel, Henry, Benros, M., Pedersen, A., Chmura, Piotr Jaroslaw, Jacobsen, U., Mari, Andrea, Koivula, R., Mahajan, Anubha, Vinuela, A., Tajes, Juan Fernandez, Sharma, Sapna, Haid, M., Hong, M., Musholt, Petra B, De Masi, Federico, Vogt, Josef, Pedersen, Helle Krogh, Gudmundsdottir, Valborg, Jones, Angus, Kennedy, G., Bell, Jimmy, Thomas, E.L., Frost, G., Thomsen, Henrik, Hansen, Elizaveta, Hansen, T., Vestergaard, Henrik, Muilwijk, Mirthe, Blom, Marieke T, 't Hart, Leen M, Pattou, Francois, Raverdy, Violeta, Brage, Soren, Kokkola, Tarja, Heggie, Alison, McEvoy, Donna, Mourby, Miranda, Kaye, J., Hattersley, A., McDonald, Timothy, Ridderstråle, M., Walker, Mark, Forgie, Ian, Giordano, Giuseppe N, Pavo, Imre, Ruetten, Hartmut, Pedersen, O., Hansen, T., Dermitzakis, Emmanouil, Franks, Paul W, Schwenk, J., Adamski, Jerzy, McCarthy, Mark I, Pearson, Ewan, Banasik, Karina, Rasmussen, S., Brunak, S. and IMI DIRECT Consortium 2023. Author Correction: Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models. Nature Biotechnology. 41 1026. https://doi.org/10.1038/s41587-023-01805-9Test

الإتاحة: https://doi.org/10.1038/s41587-023-01805-9Test
https://westminsterresearch.westminster.ac.uk/item/w31yz/author-correction-discovery-of-drug-omics-associations-in-type-2-diabetes-with-generative-deep-learning-modelsTest
https://westminsterresearch.westminster.ac.uk/download/9810d123e49a8ab66192883b3052cbe38c8896bc716f413c75645bc63d032dcf/502186/s41587-023-01805-9-1.pdfTest

المؤلفون: Franks, P. W., Cefalu, W. T., Dennis, J., Florez, J. C., Mathieu, C., Morton, R. W., Ridderstråle, M., Sillesen, H. H., Stehouwer, C. D. A.

مصطلحات موضوعية: Humans, Precision Medicine/methods, Prospective Studies, Evidence-Based Medicine, Treatment Outcome, Cardiovascular Diseases/diagnosis/therapy

العلاقة: https://linkinghub.elsevier.com/retrieve/pii/S2213-8587Test(23)00165-1; Franks PW, Cefalu WT, Dennis J, Florez JC, Mathieu C, Morton RW, et al. Precision medicine for cardiometabolic disease: a framework for clinical translation. The lancet Diabetes & endocrinology. 2023;11(11):822-35.; The lancet. Diabetes & endocrinology; https://hdl.handle.net/11287/623098Test

الإتاحة: https://doi.org/10.1016/s2213-8587Test(23)00165-1
https://hdl.handle.net/11287/623098Test

المؤلفون: Wesolowska-Andersen, A., Brorsson, C.A., Bizzotto, R., Mari, A., Tura, A., Koivula, R., Mahajan, A., Viñuela, A., Fernandez Tajes, J, Sharma, S., Haid, M., Prehn, C., Artati, A., Hong, M-G, Musholt, P.B, Kurbasic, A., Masi, F., Tsirigos, K, Pedersen, H., Gudmundsdottir, V., Thomas, C., Banasik, K., Jennison, C., Jones, A., Kennedy, G., Bell, J.D., Thomas, E.L., Frost, G., Thomsen, H., Allin, K., Hansen, T.H., Vestergaard, H., Hansen, T., Rutters, F., Elders, P., t'Hart, L., Bonnefond, A., Canouil, M., Brage, S., Kokkola, T., Heggie, A., McEvoy, D., Hattersley, A., McDonald, T., Teare, H., Ridderstrale, M., Walker, M., Forgie, I., Giordano, G.N., Froguel, P., Pavo, I., Ruetten, H., Pedersen, O., Dermitzakis, E., Franks, P.W., Schwenk, J.M., Adamski, J., Pearson, E., McCarthy, M.I., Brunak, S., IMI DIRECT Consortium

مصطلحات موضوعية: type 2 diabetes, patient stratification, patient clustering, soft-clustering archetypes, multi-omics, disease progression, glycaemic deterioration, precision medicine

وصف الملف: application/pdf

العلاقة: https://westminsterresearch.westminster.ac.uk/download/63fcaf3b747e90cd816ca0d0bdc2d12dcd496c19d814aad4fbad9f016defb448/6350322/Direct%20Four%20groups%20of%20type%202%20diabetes%20contribute%20to%20the%20etiological%20and%20clinical%20heterogeneity%20in%20newly%20diagnosed%20individuals%202022.pdfTest; https://doi.org/10.1016/j.xcrm.2021.100477Test; Wesolowska-Andersen, A., Brorsson, C.A., Bizzotto, R., Mari, A., Tura, A., Koivula, R., Mahajan, A., Viñuela, A., Fernandez Tajes, J, Sharma, S., Haid, M., Prehn, C., Artati, A., Hong, M-G, Musholt, P.B, Kurbasic, A., Masi, F., Tsirigos, K, Pedersen, H., Gudmundsdottir, V., Thomas, C., Banasik, K., Jennison, C., Jones, A., Kennedy, G., Bell, J.D., Thomas, E.L., Frost, G., Thomsen, H., Allin, K., Hansen, T.H., Vestergaard, H., Hansen, T., Rutters, F., Elders, P., t'Hart, L., Bonnefond, A., Canouil, M., Brage, S., Kokkola, T., Heggie, A., McEvoy, D., Hattersley, A., McDonald, T., Teare, H., Ridderstrale, M., Walker, M., Forgie, I., Giordano, G.N., Froguel, P., Pavo, I., Ruetten, H., Pedersen, O., Dermitzakis, E., Franks, P.W., Schwenk, J.M., Adamski, J., Pearson, E., McCarthy, M.I., Brunak, S. and IMI DIRECT Consortium 2022. Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study. Cell Reports Medicine. 3 (1) 100477. https://doi.org/10.1016/j.xcrm.2021.100477Test

الإتاحة: https://doi.org/10.1016/j.xcrm.2021.100477Test
https://westminsterresearch.westminster.ac.uk/item/vq4z3/four-groups-of-type-2-diabetes-contribute-to-the-etiological-and-clinical-heterogeneity-in-newly-diagnosed-individuals-an-imi-direct-studyTest
https://westminsterresearch.westminster.ac.uk/download/63fcaf3b747e90cd816ca0d0bdc2d12dcd496c19d814aad4fbad9f016defb448/6350322/Direct%20Four%20groups%20of%20type%202%20diabetes%20contribute%20to%20the%20etiological%20and%20clinical%20heterogeneity%20in%20newly%20diagnosed%20individuals%202022.pdfTest

المؤلفون: Wesolowska-Andersen, A, Brorsson, CA, Bizzotto, R, Mari, A, Tura, A, Koivula, R, Mahajan, A, Vinuela, A, Tajes, JF, Sharma, S, Haid, M, Prehn, C, Artati, A, Hong, MG, Musholt, PB, Kurbasic, A, De Masi, F, Tsirigos, K, Pedersen, HK, Gudmundsdottir, V, Thomas, CE, Banasik, K, Jennison, C, Jones, A, Kennedy, G, Bell, J, Thomas, L, Frost, G, Thomsen, H, Allin, K, Hansen, TH, Vestergaard, H, Hansen, T, Rutters, F, Elders, P, t'Hart, L, Bonnefond, A, Canouil, M, Brage, S, Kokkola, T, Heggie, A, McEvoy, D, Hattersley, A, McDonald, T, Teare, H, Ridderstrale, M, Walker, M, Forgie, I, Giordano, GN, Froguel, P, Pavo, I, Ruetten, H, Pedersen, O, Dermitzakis, E, Franks, PW, Schwenk, JM, Adamski, J, Pearson, E, McCarthy, MI, Brunak, S

المصدر: nlmid: 101766894 ; essn: 2666-3791

مصطلحات موضوعية: archetypes, disease progression, glycaemic deterioration, multi-omics, patient clustering, patient stratification, precision medicine, soft-clustering, type 2 diabetes, Adult, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Genetic Predisposition to Disease, Genomics, Humans, Male, Middle Aged, Phenotype, Risk Factors

وصف الملف: application/pdf

العلاقة: https://www.repository.cam.ac.uk/handle/1810/334703Test

الإتاحة: https://doi.org/10.17863/CAM.82121Test
https://www.repository.cam.ac.uk/handle/1810/334703Test

المؤلفون: Obura, M., Beulens, J. W.J., Slieker, R., Koopman, A. D.M., Hoekstra, T., Nijpels, G., Elders, P., Dekker, J. M., Koivula, R. W., Kurbasic, A., Laakso, M., Hansen, T. H., Ridderstråle, M., Hansen, T., Pavo, I., Forgie, I., Jablonka, B., Ruetten, H., Mari, A., McCarthy, M. I., Walker, M., McDonald, T. J., Perry, M. H., Pearson, E. R., Franks, P. W., ‘t Hart, L. M., Rutters, F.

المصدر: Diabetic Medicine EXODIAB: Excellence of Diabetes Research in Sweden EpiHealth: Epidemiology for Health. 38(2)

مصطلحات موضوعية: Medicin och hälsovetenskap, Klinisk medicin, Endokrinologi och diabetes, Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes

الوصول الحر: https://lup.lub.lu.se/record/f94ba062-1244-4b13-b412-e2d88439d9ceTest
http://dx.doi.org/10.1111/dme.14428Test

المؤلفون: Tura, A., Grespan, E., Göbl, C. S., Koivula, R. W., Franks, P. W., Pearson, E. R., Walker, M., Forgie, I. M., Giordano, G. N., Pavo, I., Ruetten, H., Dermitzakis, E. T., McCarthy, M. I., Pedersen, O., Schwenk, J. M., Adamski, J., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., Mahajan, A., McDonald, T. J., Kokkola, T., Vangipurapu, J., Cederberg, H., Laakso, M., Rutters, F., Elders, P. J. M., Koopman, A. D. M., Beulens, J. W., Ridderstråle, M., Hansen, T. H., Allin, K. H., Hansen, T., Vestergaard, H., Mari, A.

العلاقة: https://diabetes.diabetesjournals.org/lookup/pmidlookup?view=long&pmid=34233929Test; Tura, A., Grespan, E., Göbl, C. S., Koivula, R. W., Franks, P. W., Pearson, E. R., Walker, M., Forgie, I. M., Giordano, G. N., Pavo, I., Ruetten, H., Dermitzakis, E. T., McCarthy, M. I., Pedersen, O., Schwenk, J. M., Adamski, J., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., Mahajan, A., McDonald, T. J., Kokkola, T., Vangipurapu, J., Cederberg, H., Laakso, M., Rutters, F., Elders, P. J. M., Koopman, A. D. M., Beulens, J. W., Ridderstråle, M., Hansen, T. H., Allin, K. H., Hansen, T., Vestergaard, H. and Mari, A. (2021) 'Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study', Diabetes.; https://rde.dspace-express.com/handle/11287/621987Test; Diabetes

الإتاحة: https://doi.org/10.2337/db21-0227Test
https://rde.dspace-express.com/handle/11287/621987Test

المؤلفون: Atabaki-Pasdar, N., Ohlsson, M., Viñuela, A., Frau, F., Pomares-Millan, H., Haid, M., Jones, A., Thomas, E.L., Koivula, R., Kurbasic, A., Mutie, P., Fitipaldi, H., Fernandez, J., Dawed, A., Giordano, G., Forgie, I., McDonald, T., Rutters, F., Cederberg, H., Chabanova, E., Dale, M., Masi, F., Thomas, C., Allin, K., Hansen, T., Heggie, A., Hong, M., Elders, P., Kennedy, G., Kokkola, T., Pedersen, H., Mahajan, A., McEvoy, D., Pattou, F., Raverdy, V., Häussler, R., Sharma, S., Thomsen, H., Vangipurapu, J., Vestergaard, H., ‘t Hart, L., Adamski, J., Musholt, P., Brage, S., Brunak, S., Dermitzakis, E., Frost, G., Laakso, M., Pedersen, O., Ridderstråle, M., Ruetten, H., Hattersley, A., Walker, M., Beulens, J., Mari, A., Schwenk, J., Gupta, R., McCarthy, M., Pearson, E., Bell, J.D., Pavo, I., Franks, P.

وصف الملف: application/pdf

العلاقة: https://westminsterresearch.westminster.ac.uk/download/e46370fe9b4ee0ddb49728f3b63098835904ba8138de1bccdd6cbd9bed548d6a/2224476/journal.pmed.1003149.pdfTest; https://doi.org/10.1371/journal.pmed.1003149Test; Atabaki-Pasdar, N., Ohlsson, M., Viñuela, A., Frau, F., Pomares-Millan, H., Haid, M., Jones, A., Thomas, E.L., Koivula, R., Kurbasic, A., Mutie, P., Fitipaldi, H., Fernandez, J., Dawed, A., Giordano, G., Forgie, I., McDonald, T., Rutters, F., Cederberg, H., Chabanova, E., Dale, M., Masi, F., Thomas, C., Allin, K., Hansen, T., Heggie, A., Hong, M., Elders, P., Kennedy, G., Kokkola, T., Pedersen, H., Mahajan, A., McEvoy, D., Pattou, F., Raverdy, V., Häussler, R., Sharma, S., Thomsen, H., Vangipurapu, J., Vestergaard, H., ‘t Hart, L., Adamski, J., Musholt, P., Brage, S., Brunak, S., Dermitzakis, E., Frost, G., Hansen, T., Laakso, M., Pedersen, O., Ridderstråle, M., Ruetten, H., Hattersley, A., Walker, M., Beulens, J., Mari, A., Schwenk, J., Gupta, R., McCarthy, M., Pearson, E., Bell, J.D., Pavo, I. and Franks, P. 2020. Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts. PLoS Medicine. 17 (6) e1003149. https://doi.org/10.1371/journal.pmed.1003149Test

الإتاحة: https://doi.org/10.1371/journal.pmed.1003149Test
https://westminsterresearch.westminster.ac.uk/item/qzw5v/predicting-and-elucidating-the-etiology-of-fatty-liver-disease-a-machine-learning-modeling-and-validation-study-in-the-imi-direct-cohortsTest
https://westminsterresearch.westminster.ac.uk/download/e46370fe9b4ee0ddb49728f3b63098835904ba8138de1bccdd6cbd9bed548d6a/2224476/journal.pmed.1003149.pdfTest