دورية أكاديمية
Deep eutectic solvent self-assembled reverse nanomicelles for transdermal delivery of sparingly soluble drugs
| العنوان: | Deep eutectic solvent self-assembled reverse nanomicelles for transdermal delivery of sparingly soluble drugs |
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| المؤلفون: | Bin Li, Siwen Jiao, Shiqi Guo, Ting Xiao, Yao Zeng, Yingwei Hu, Xiaojuan Li, Sha Xiong, Yuehong Xu |
| المصدر: | Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-22 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biotechnology LCC:Medical technology |
| مصطلحات موضوعية: | Transdermal delivery, Deep eutectic solvent, Self-assembly, Reverse nanomicelle, Computational simulation, Anti-psoriasis, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | Abstract Background Transdermal delivery of sparingly soluble drugs is challenging due to their low solubility and poor permeability. Deep eutectic solvent (DES)/or ionic liquid (IL)-mediated nanocarriers are attracting increasing attention. However, most of them require the addition of auxiliary materials (such as surfactants or organic solvents) to maintain the stability of formulations, which may cause skin irritation and potential toxicity. Results We fabricated an amphiphilic DES using natural oxymatrine and lauric acid and constructed a novel self-assembled reverse nanomicelle system (DES-RM) based on the features of this DES. Synthesized DESs showed the broad liquid window and significantly solubilized a series of sparingly soluble drugs, and quantitative structure-activity relationship (QSAR) models with good prediction ability were further built. The experimental and molecular dynamics simulation elucidated that the self-assembly of DES-RM was adjusted by noncovalent intermolecular forces. Choosing triamcinolone acetonide (TA) as a model drug, the skin penetration studies revealed that DES-RM significantly enhanced TA penetration and retention in comparison with their corresponding DES and oil. Furthermore, in vivo animal experiments demonstrated that TA@DES-RM exhibited good anti-psoriasis therapeutic efficacy as well as biocompatibility. Conclusions The present study offers innovative insights into the optimal design of micellar nanodelivery system based on DES combining experiments and computational simulations and provides a promising strategy for developing efficient transdermal delivery systems for sparingly soluble drugs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1477-3155 |
| العلاقة: | https://doaj.org/toc/1477-3155Test |
| DOI: | 10.1186/s12951-024-02552-y |
| الوصول الحر: | https://doaj.org/article/3390440f9faa451e8b41293f7c086ee8Test |
| رقم الانضمام: | edsdoj.3390440f9faa451e8b41293f7c086ee8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14773155 |
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| DOI: | 10.1186/s12951-024-02552-y |