المؤلفون: HAROSA I Study Grp, Pepin, Jean-Louis, Georgiev, Ognian, Tiholov, Rumen, Partinen, Markku, Dauvilliers, Yves

المساهمون: Department of Neurosciences, HUS Neurocenter, Neurologian yksikkö, University of Helsinki

مصطلحات موضوعية: CPAP, OSA, pitolisant, residual excessive daytime sleepiness, IMPORTANT DIFFERENCE, APNEA PATIENTS, DOUBLE-BLIND, PLACEBO, NARCOLEPSY, SCALE, 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: Author contributions: J.-L. P. takes responsibility for the content of the manuscript, including the data and analysis. I. L. and J.-M. L. participated in the conception, design, and organization of the study. Y. D. and J.-L. P. participated in the conception and design of the study and wrote the article. J.-C. S. participated in the conception and design and minor revision of the article. O. G. R. Tiholov, V. A. J. V. B. B. M. P. I. F. G. B. D. D. R. Tamisier, and P. L. were investigators or coordinators of the study and assisted in revising the manuscript. All authors shared the decision to submit the manuscript for publication. Financial/nonfinancial disclosures: The authors have reported to CHEST the following: Y. D. has consulted for UCB Pharma, Jazz, Theranexus, Flamel, Idorsia, Takeda, Harmony Biosciences, and Bioprojet. J.-L. P. reports other from Bioprojet, Jazz Pharmaceuticals, and Idorsia, during the conduct of the study; grants from Air Liquide Foundation, Fisher, Paykel, Mutualia, Vitalaire, Boehringer Ingelheim, Jazz Pharmaceuticals, Night Balance, and Sefam, all outside the submitted work; and grants and personal fees from Agiradom, AstraZeneca, Philips, Resmed, all outside the submitted work. J. V. reports grants from Antwerp University Hospital, during the conduct of the study; and grants from Bioprojet, Jazz Pharmaceuticals, and UCB Pharma, outside the submitted work. B. B. reports reimbursement fees for travel and conference expenses from VitalAire, outside the submitted work. R. Tamisier reports other from Agiradom (Healthcare provider) and grants from Resmed, both outside the submitted work. J.-C. S. and J.-M. L. are co-founders and shareholders of Bioprojet pharma and Bioprojet biotech. I. L. is an employee of Bioprojet pharma. None declared (O. G. R. Tiholov, V. A. M. P. I. F. G. B. D. D, P. L.). Role of sponsors: The sponsor had no role in the design of the study, the collection and analysis of the data, or the preparation of the manuscript. ?HAROSA I Study Group Collaborators: Valerie Attali, MD, PhD, Sleep Disorder Unit, la Piti?-Salp?tri?re Hospital, Paris, France; Patrice Bourgin, MD, PhD, H?pital Civil, Strasbourg, France; Yves Dauvilliers, MD, PhD, Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, Montpellier, France; Marie D'Ortho, MD, PhD, Unit? Epreuves Fonctionnelles Respiratoires, Hopital Bichat, Paris, France; Frederic Gagnadoux, MD, PhD, Department of Pneumology, CHU Angers, France; Jean Claude Meurice, MD, Pneumology CHU Poitiers, France; Xuan Lan Nguyen, MD, Saint Antoine Hospital, Paris, France; Jean-Louis P?pin, MD, PhD, Unit? Epreuves Fonctionnelles Respiratoires, Michallon Hospital, La Tronche, France; Bertien Buyse, MD, PhD, Leuvens Universitair Centrum voor Slaap- en waakstoornissen, University Hospitals Leuven, Leuven, Belgium; Katrien Hertegonne, MD, PhD, Pneumology Polyclinic, Ghent, Belgium; Daniel Rodenstein, MD, PhD, Pneumology Saint Luc Clinic, Brussels, Belgium; Johan Verbraecken, MD, PhD, Multidisciplinary Sleep Disorders Centre, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium; Jan Ovesen, MD, Sleep Clinical Trial Aps, Kodling, Denmark; Soren Berg, MD, Scan Sleep ApS, Sovnlaegecentret, Copenhagen, Denmark; Markku Partinen, MD, PhD, Helsinki Sleep Clinic, Helsinki, Finland; Olli Polo, MD, PhD, Unesta Research Center, Tampere, Finland; Tarja Saaresranta, MD, PhD, Sleep Research Unit, University of Turku, Turku, Finland; Jan Anders Hedner, MD, PhD, Sleep Medicine Clinic, Sahlgrenska University Hospital, Gothenburg, Sweden; Y?ksel Peker, MD, PhD, Ko? University School of Medicine, Istanbul, Turkey; Ingo Fietze, MD, Interdisziplin?res Schlafmedizinesches Zentrum, Charit?, Berlin, Germany; W. J. Randerath, MD, Pneumology Institut Witten Herdecke, Solingen, Germany; Elke R?ssner, MD, Pneumology and Sleep Medicine Clinic, Nurenberg, Germany; Diego Garcia Borreguero, MD, Sleep Research Institute, Madrid, Spain; Francisco Javier Puertas Cuesta, MD, PhD, Sleep Unit, Neurophysiology Department, Ribera Hospital, Valencia, Spain; Joaquim Duran-Cantolla, MD, Sleep Disorder Unit, Txagorritxu Hospital, Vitoria Gasteiz, Spain; Ferran Barbe, MD, PhD, Vilanova de Lleida, Lleida, Spain; Dra Odile Romero, MD, Neurophysiology Unit, Vall d'Hebron Hospital, Barcelona, Spain; Georgi Belev, MD, Department of Pneumology, Saint George Hospital, Plovdiv, Bulgaria; Ognian Georgiev, MD, PhD, Department of Pneumology, Alexandrovska Hospital, Sofia, Bulgaria; Yavor Ivanov, MD, Clinic of Pneumology, Pleven, Bulgaria; Hristo Metev, MD, PhD, Department of Pneumology, Rousse, Bulgaria; Diana Petkova, MD, Department of Pneumology, Varna, Bulgaria; Rumen Tiholov, MD, Department of Internal Diseases, Kozloduy, Bulgaria; Dejan Dokic, MD, PhD, Department of Pneumology and Allergy, Mother Teresa Medical University, Skopje, Macedonia; and Merita Ismajli Marku, MD, Neuropraxis, Skopje, Macedonia. Other contributions: The authors thank Alison Foote, PhD, Grenoble Alpes University Hospital, Grenoble, France, for editing the manuscript. Data sharing statement: Data collected for the study, including de-identified individual participant data and a data dictionary defining each field in the set, will be made available to others after the publication of this article, as well as additional related documents (study protocol, statistical analysis plan, informed consent form) for academic purposes (eg, meta-analyses) on request to the sponsor Bioprojet (jm.lecomte@bioprojet.com) and with a signed data access agreement. Additional information: The e-Appendix and e-Tables can be found in the Supplemental Materials section of the online article. FUNDING/SUPPORT: This study was funded by Bioprojet, Paris, France.; HAROSA I Study Grp , Pepin , J-L , Georgiev , O , Tiholov , R , Partinen , M & Dauvilliers , Y 2021 , ' Pitolisant for Residual Excessive Daytime Sleepiness in OSA Patients Adhering to CPAP A Randomized Trial ' , Chest , vol. 159 , no. 4 , pp. 1598-1609 . https://doi.org/10.1016/j.chest.2020.09.281Test; ORCID: /0000-0002-8182-9368/work/95863912; 3806f216-9bde-42e1-978a-0dec33b823ab; http://hdl.handle.net/10138/342487Test; 000637558400064

الإتاحة: http://hdl.handle.net/10138/342487Test

المؤلفون: Pépin, Jean-Louis, Georgiev, Ognian, Tiholov, Rumen, Attali, Valérie, Verbraecken, Johan, Buyse, Bertien, Partinen, Markku, Fietze, Ingo, Belev, Georgi, Dokic, Dejan, Tamisier, Renaud, Lévy, Patrick, Lecomte, Isabelle, Lecomte, Jeanne-Marie, Schwartz, Jean-Charles, Dauvilliers, Yves, Bourgin, Patrice, D’ortho, Marie, Gagnadoux, Frederic, Meurice, Jean Claude, Nguyen, Xuan Lan, Hertegonne, Katrien, Rodenstein, Daniel, Ovesen, Jan, Berg, Soren, Polo, Olli, Saaresranta, Tarja, Hedner, Jan Anders, Peker, Yuksel, Randerath, W.J., Rössner, Elke, Borreguero, Diego Garcia, Puertas Cuesta, Francisco Javier, Duran-Cantolla, Joaquim, Barbe, Ferran, Romero, Dra Odile, Ivanov, Yavor, Metev, Hristo, Petkova, Diana, Marku, Merita Ismajli

المساهمون: Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire CHU Grenoble (CHUGA), University Hospital Alexandrovska, St. Ivan Rilski University Hospital, Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Antwerp University Hospital Edegem (UZA), University Hospitals Leuven Leuven, Catholic University of Leuven = Katholieke Universiteit Leuven (KU Leuven), Helsinki Sleep Clinic Helsinki, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Charité - UniversitätsMedizin = Charité - University Hospital Berlin, St. George Hospital Medical University Plovidv, University Hospital Center “Mother Teresa", Bioprojet, Département de neurologie Montpellier, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Hôpital Gui de Chauliac CHU Montpellier, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Université de Montpellier (UM), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)

المصدر: ISSN: 0012-3692.

مصطلحات موضوعية: CPAP, OSA, pitolisant, residual excessive daytime sleepiness, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33121980; hal-03270752; https://hal.umontpellier.fr/hal-03270752Test; https://hal.umontpellier.fr/hal-03270752/documentTest; https://hal.umontpellier.fr/hal-03270752/file/S0012369220351059.pdfTest; PII: S0012-3692(20)35105-9; PUBMED: 33121980

الإتاحة: https://doi.org/10.1016/j.chest.2020.09.281Test
https://hal.umontpellier.fr/hal-03270752Test
https://hal.umontpellier.fr/hal-03270752/documentTest
https://hal.umontpellier.fr/hal-03270752/file/S0012369220351059.pdfTest

المؤلفون: Pablo R. Castillo, Reena Mehra, Raphael Heinzer

المصدر: Neurology and Therapy

مصطلحات موضوعية: medicine.medical_specialty, Neurology, business.industry, medicine.medical_treatment, Epworth Sleepiness Scale, Continuous positive airway pressure, Excessive daytime sleepiness, Review, medicine.disease, Obstructive sleep apnea, Residual excessive daytime sleepiness, Current management, medicine, Effective treatment, Orexin, In patient, Neurology (clinical), medicine.symptom, business, Intensive care medicine, Hypoxia

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d8dc2116c65faeacd2143dffeb1c1eTest
http://europepmc.org/articles/PMC8520824Test

المؤلفون: Jean-Louis Pépin, Ognian Georgiev, Rumen Tiholov, Valérie Attali, Johan Verbraecken, Bertien Buyse, Markku Partinen, Ingo Fietze, Georgi Belev, Dejan Dokic, Renaud Tamisier, Patrick Lévy, Isabelle Lecomte, Jeanne-Marie Lecomte, Jean-Charles Schwartz, Yves Dauvilliers, Valerie Attali, Patrice Bourgin, Marie D’Ortho, Frederic Gagnadoux, Jean Claude Meurice, Xuan Lan Nguyen, Katrien Hertegonne, Daniel Rodenstein, Jan Ovesen, Soren Berg, Olli Polo, Tarja Saaresranta, Jan Anders Hedner, Yuksel Peker, W.J. Randerath, Elke Rössner, Diego Garcia Borreguero, Francisco Javier Puertas Cuesta, Joaquim Duran-Cantolla, Ferran Barbe, Dra Odile Romero, Yavor Ivanov, Hristo Metev, Diana Petkova, Merita Ismajli Marku

المساهمون: Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), CHU Grenoble, University Hospital Alexandrovska, St. Ivan Rilski University Hospital, Neurophysiologie Respiratoire Expérimentale et Clinique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service des Pathologies du sommeil [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Antwerp University Hospital [Edegem] (UZA), University Hospitals Leuven [Leuven], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Helsinki Sleep Clinic [Helsinki], University of Helsinki, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], St. George Hospital Medical University [Plovidv], University Hospital Center 'Mother Teresa', Bioprojet, Département de neurologie [Montpellier], Hôpital Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)

المصدر: Chest
Chest, American College of Chest Physicians, 2021, 159 (4), pp.1598-1609. ⟨10.1016/j.chest.2020.09.281⟩

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Pitolisant, Population, Excessive daytime sleepiness, Critical Care and Intensive Care Medicine, Placebo, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, law.invention, OSA, 03 medical and health sciences, chemistry.chemical_compound, residual excessive daytime sleepiness, 0302 clinical medicine, Randomized controlled trial, CPAP, law, medicine, 030212 general & internal medicine, education, pitolisant, education.field_of_study, Intention-to-treat analysis, business.industry, Epworth Sleepiness Scale, respiratory tract diseases, 3. Good health, 030228 respiratory system, Apnea–hypopnea index, chemistry, Physical therapy, medicine.symptom, Cardiology and Cardiovascular Medicine, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3ccc4b6cff98bc547ba2310ab07a6eTest
https://doi.org/10.1016/j.chest.2020.09.281Test

المؤلفون: Mehra, R., Heinzer, R., Castillo, P.

المصدر: Neurology and therapy, vol. 10, no. 2, pp. 651-672

مصطلحات موضوعية: Continuous positive airway pressure, Epworth Sleepiness Scale, Hypoxia, Obstructive sleep apnea, Orexin, Residual excessive daytime sleepiness

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______1900::d8623108286058a011023b2bb63b1cf5Test
https://serval.unil.ch/resource/serval:BIB_8C4770D2E079.P001/REF.pdfTest

المؤلفون: HAROSA I Study Grp, Pepin, Jean-Louis, Georgiev, Ognian, Tiholov, Rumen, Partinen, Markku, Dauvilliers, Yves

المساهمون: Department of Neurosciences, HUS Neurocenter, Neurologian yksikkö, University of Helsinki

مصطلحات موضوعية: OSA, DOUBLE-BLIND, residual excessive daytime sleepiness, IMPORTANT DIFFERENCE, PLACEBO, CPAP, 3121 General medicine, internal medicine and other clinical medicine, APNEA PATIENTS, NARCOLEPSY, pitolisant, SCALE

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______1593::e891d91a9a6b09dbecca95b95e83afdbTest
http://hdl.handle.net/10138/342487Test

المؤلفون: Pepin, Jean-Louis, Georgiev, Ognian, Tiholov, Rumen, Attali, Valerie, Verbraecken, Johan, Buyse, Bertien, Partinen, Markku, Fietze, Ingo, Belev, Georgi, Dokic, Dejan, Tamisier, Renaud, Levy, Patrick, Lecomte, Isabelle, Lecomte, Jeanne-Marie, Schwartz, Jean-Charles, Dauvilliers, Yves

المساهمون: HAROSA I Study Group

المصدر: Chest

مصطلحات موضوعية: Obstructive Sleep Apnea, Continuous Positive Airway Pressure, Human medicine, pitolisant, residual Excessive Daytime Sleepiness

وصف الملف: Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bc8554a58a4b5c908ac122a7a5819d8aTest
https://hdl.handle.net/10067/1862950151162165141Test