دورية أكاديمية
Short-term exercise training early in life restores deficits in pancreatic β-cell mass associated with growth restriction in adult male rats
| العنوان: | Short-term exercise training early in life restores deficits in pancreatic β-cell mass associated with growth restriction in adult male rats |
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| المؤلفون: | Laker, Rhianna C, Gallo, Linda A, Wlodek, Mary E, Siebel, Andrew L, Wadley, Glenn D, McConell, Glenn |
| بيانات النشر: | American Physiological Society |
| سنة النشر: | 2011 |
| المجموعة: | Victoria University Melbourne: VU Eprint Repository |
| مصطلحات موضوعية: | Institute of Sport, Exercise and Active Living (ISEAL), 0606 Physiology, 9201 Clinical Health (Organs, Diseases and Abnormal Conditions), ResPubID24361, β-cell, fetal size, insulin secretion |
| الوصف: | Fetal growth restriction is associated with reduced pancreatic β-cell mass, contributing to impaired glucose tolerance and diabetes. Exercise training increases β-cell mass in animals with diabetes and has long-lasting metabolic benefits in rodents and humans. We studied the effect of exercise training on islet and β-cell morphology and plasma insulin and glucose, following an intraperitoneal glucose tolerance test (IPGTT) in juvenile and adult male Wistar-Kyoto rats born small. Bilateral uterine vessel ligation performed on day 18 of pregnancy resulted in Restricted offspring born small compared with sham-operated Controls and also sham-operated Reduced litter offspring that had their litter size reduced to five pups at birth. Restricted, Control, and Reduced litter offspring remained sedentary or underwent treadmill running from 5 to 9 or 20 to 24 wk of age. Early life exercise increased relative islet surface area and β-cell mass across all groups at 9 wk, partially restoring the 60–68% deficit (P < 0.05) in Restricted offspring. Remarkably, despite no further exercise training after 9 wk, β-cell mass was restored in Restricted at 24 wk, while sedentary littermates retained a 45% deficit (P = 0.05) in relative β-cell mass. Later exercise training also restored Restricted β-cell mass to Control levels. In conclusion, early life exercise training in rats born small restored β-cell mass in adulthood and may have beneficial consequences for later metabolic health and disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://vuir.vu.edu.au/9406Test/; Laker, Rhianna C, Gallo, Linda A, Wlodek, Mary E, Siebel, Andrew L, Wadley, Glenn D and McConell, Glenn orcid:0000-0002-8572-9065 (2011) Short-term exercise training early in life restores deficits in pancreatic β-cell mass associated with growth restriction in adult male rats. American Journal of Physiology - Endocrinology and Metabolism, 301 (5). E931-E940. ISSN 0193-1849 (print) 1522-1555 (online) |
| DOI: | 10.1152/ajpendo.00114.2011 |
| الإتاحة: | https://doi.org/10.1152/ajpendo.00114.2011Test https://vuir.vu.edu.au/9406Test/ http://ajpendo.physiology.org/content/301/5/E931.abstractTest |
| رقم الانضمام: | edsbas.88A91C01 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1152/ajpendo.00114.2011 |
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