دورية أكاديمية
Comparative study of the efficacy of olmesartan/amlodipine vs. perindopril/amlodipine in peripheral blood pressure after missed dose in type 2 diabetes
| العنوان: | Comparative study of the efficacy of olmesartan/amlodipine vs. perindopril/amlodipine in peripheral blood pressure after missed dose in type 2 diabetes |
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| المؤلفون: | Redon J, Pichler G, Missed Dose Study Group ( Lembo G, Benedetto FA, De Curtis G, Desideri G, Dognini GP, Ferri C, Fogari R, Ganau A, Gargiulo A, Gaudio G, Germanò G, Malatino L, Bucci M, Mos L, Novo S, Pedrinelli R, Perticone F, Portaluppi F, Mulé G, Sarzani R, Schillaci G, Spagnuolo V, Strazzullo P, Taddei S, Trimarco B, Veglio F, Verdecchia P, Volpe M) |
| المساهمون: | Redon J, Pichler G, Missed Dose Study Group, ( Lembo G, Benedetto, Fa, De Curtis, G, Desideri, G, Dognini, Gp, Ferri, C, Fogari, R, Ganau, A, Gargiulo, A, Gaudio, G, Germanò, G, Malatino, L, Bucci, M, Mos, L, Novo, S, Pedrinelli, R, Perticone, F, Portaluppi, F, Mulé, G, Sarzani, R, Schillaci, G, Spagnuolo, V, Strazzullo, P, Taddei, S, Trimarco, B, Veglio, F, Verdecchia, P, Volpe, M) |
| سنة النشر: | 2016 |
| المجموعة: | ARUd'A - Archivio Istituzionale della ricerca dell'università Chieti-Pescara (IRIS) |
| مصطلحات موضوعية: | Amlodipine, Antihypertensive agent, Blood pressure, Diabetes mellitu, Olmesartan, Perindopril, Adult, Aged, Angiotensin II Type 1 Receptor Blocker, Angiotensin-Converting Enzyme Inhibitor, Calcium Channel Blocker, Diabetes Mellitus, Type 2, Double-Blind Method, Drug Combination, Female, Human, Hypertension, Imidazole, Male, Medication Adherence, Middle Aged, Tetrazole, Treatment Outcome, Internal Medicine, Physiology, Cardiology and Cardiovascular Medicine |
| الوصف: | BACKGROUND: Central aortic blood pressure (CBP) and CBP-derived parameters are independent predictors of cardiovascular risk. Angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme inhibitors plus calcium channel blockers are the recommended first-line treatments in hypertensive diabetic patients; however, the effect in reducing CBP when a dose is skipped has not been established yet. The aim was to determine whether the fixed-dose combination of olmesartan/amlodipine (OLM/AML) provides equal efficacy and safety as the perindopril/AML (PER/AML) combination in reducing CBP, augmentation index (AIx), and pulse wave velocity (PWV) when a drug dose is missed. METHODS: In this noninferiority, randomized, double-blind, double-dummy parallel group, controlled design trial, 88 patients received either OLM 20-40mg/AML 5-10mg (41 patients) or PER 4-8mg/AML 5-10mg (47 patients) for 24 weeks. The main endpoint was the aortic systolic BP (SBP) after 24 weeks of treatment at 48 hours from the last administration. RESULTS: The OLM/AML combination reached the noninferiority criteria in reducing central systolic BP after 24 weeks of treatment and after the missed dose, compared to the PER/AML combination (-17 and -8mm Hg, respectively). Peripheral BP, AIx, and PWV were significantly lower in both groups after 24 weeks of treatment and 48 hours after the missed dose, observing a trend to a greater reduction in CBP-derived parameters in the OLM/AML group. CONCLUSIONS: The OLM/AML combination is safe, well tolerated, and not inferior to the combination of PER/AML in lowering CBP and CBP-derived parameters in diabetic patients. OLM/AML provides longer-lasting efficacy in terms of CBP reduction compared to PER/AML. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26867060; info:eu-repo/semantics/altIdentifier/wos/WOS:000369671400028; volume:34; issue:2; firstpage:359; lastpage:367; numberofpages:9; journal:JOURNAL OF HYPERTENSION; https://hdl.handle.net/11564/686194Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84957563456; http://journals.lww.com/jhypertensionTest |
| DOI: | 10.1097/HJH.0000000000000793 |
| الإتاحة: | https://doi.org/10.1097/HJH.0000000000000793Test https://hdl.handle.net/11564/686194Test http://journals.lww.com/jhypertensionTest |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.4F6B8638 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/HJH.0000000000000793 |
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