Parathyroid hormone receptor stimulation induces human adipocyte lipolysis and browning
| العنوان: | Parathyroid hormone receptor stimulation induces human adipocyte lipolysis and browning |
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| المؤلفون: | Niels Jessen, Bjørn Richelsen, Steen B. Pedersen, Peter Breining, Jacob B. Hansen, Mads Kjolby |
| المصدر: | Breining, P, Pedersen, S B, Kjolby, M, Hansen, J B, Jessen, N & Richelsen, B 2021, ' Parathyroid hormone receptor stimulation induces human adipocyte lipolysis and browning ', European Journal of Endocrinology, vol. 184, no. 5, pp. 687-697 . https://doi.org/10.1530/EJE-20-0713Test |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, endocrine system, medicine.medical_specialty, Adipose Tissue, Brown/metabolism, Lipolysis, Endocrinology, Diabetes and Metabolism, Receptor expression, Parathyroid hormone, Adipose tissue, Parathyroid Hormone/pharmacology, 030209 endocrinology & metabolism, White adipose tissue, Lipolysis/drug effects, Adipose Tissue/drug effects, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Adipose Tissue, Brown, Receptor, Parathyroid Hormone, Type 1/metabolism, Adipocyte, Internal medicine, Brown adipose tissue, Adipocytes, medicine, Humans, Uncoupling Protein 1, Receptor, Parathyroid Hormone, Type 1, Aged, Chemistry, Thermogenesis/drug effects, Thermogenesis, Uncoupling Protein 1/metabolism, General Medicine, Middle Aged, Thermogenin, Cross-Sectional Studies, medicine.anatomical_structure, Adipose Tissue, Parathyroid Hormone, 030220 oncology & carcinogenesis, Female, hormones, hormone substitutes, and hormone antagonists, Adipocytes/drug effects |
| الوصف: | Objective Activation of brown adipose tissue is a promising strategy to treat and prevent obesity and obesity-related disorders. Activation of uncoupling protein 1 (UCP1) leads to uncoupled respiration and dissipation of stored energy as heat. Induction of UCP1-rich adipocytes in white adipose tissue, a process known as ‘browning’, serves as an alternative strategy to increase whole body uncoupling capacity. Here, we aim to assess the association between parathyroid hormone (PTH) receptor expression and UCP1 expression in human adipose tissues and to study PTH effects on human white and brown adipocyte lipolysis and UCP1 expression. Design A descriptive study of human neck adipose tissue biopsies substantiated by an interventional study on human neck-derived adipose tissue cell models. Methods Thermogenic markers and PTH receptor gene expression are assessed in human neck adipose tissue biopsies and are related to individual health records. PTH-initiated lipolysis and thermogenic gene induction are assessed in cultured human white and brown adipocyte cell models. PTH receptor involvement is investigated by PTH receptor silencing. Results PTH receptor gene expression correlates with UCP1 gene expression in the deep-neck adipose tissue in humans. In cell models, PTH receptor stimulation increases lipolysis and stimulates gene transcription of multiple thermogenic markers. Silencing of the PTH receptor attenuates the effects of PTH indicating a direct PTH effect via this receptor. Conclusion PTH 1 receptor stimulation by PTH may play a role in human adipose tissue metabolism by affecting lipolysis and thermogenic capacity. |
| تدمد: | 1479-683X 0804-4643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9393d6212f2abdcb21a7db48ea58f29Test https://doi.org/10.1530/eje-20-0713Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....b9393d6212f2abdcb21a7db48ea58f29 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1479683X 08044643 |
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