المؤلفون: Anthony P. Coll, MN Bedenbaugh, DT Porter, David H. Rowitch, John R. B. Perry, D A van Heel, X Dai, Rachel N. Lippert, Debra Rimmington, A. L. Gonçalves Soares, Felix R. Day, Duckett K, Patrick Sweeney, Zhaoyang Xu, Ahsan Nabi Khan, Hilary C. Martin, John Tadross, Roger D. Cone, Brian Y.H. Lam, Klj Ellacott, Richard B. Simerly, J Rosmaninho-Salgado, Alice E. Williamson, Gkc Dowsett, Sarah Finer, Irene Cimino, Giles S.H. Yeo, Audrey Melvin, Kara Rainbow, Claudia Langenberg, Stephen O'Rahilly, Nicholas J. Wareham, Katherine Ridley, Richard C. Trembath, Staffan Holmqvist, Sophie Buller, N J Timpson, Kaitlin H Wade, Ken K. Ong, Elena G. Bochukova

المصدر: Nature
2021, ' MC3R links nutritional state to childhood growth and the timing of puberty ', Nature, vol. 599, no. 7885, pp. 436-441 . https://doi.org/10.1038/s41586-021-04088-9Test

مصطلحات موضوعية: Male, medicine.medical_specialty, Time Factors, Calorie, Adolescent, media_common.quotation_subject, Hypothalamus, Nutritional Status, Estrous Cycle, Nutrient sensing, Biology, Weight Gain, Article, Mice, Child Development, Central melanocortin system, Internal medicine, medicine, Animals, Humans, Sexual maturity, Obesity, Sexual Maturation, Insulin-Like Growth Factor I, Child, media_common, Aged, 80 and over, Menarche, Multidisciplinary, Homozygote, Puberty, Appetite, Melanocortins, Melanocortin 4 receptor, Phenotype, medicine.anatomical_structure, Endocrinology, Lean body mass, Female, Melanocortin, Receptor, Melanocortin, Type 3

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2690bb58b6dc1e9ea01491ecfdde0e49Test
https://doi.org/10.1038/s41586-021-04088-9Test

المؤلفون: Andrew M. White, Anita Dellsén, Niklas Larsson, Quentin Kaas, Frank Jansen, Alleyn T. Plowright, Laurent Knerr, Thomas Durek, David J. Craik

المصدر: Journal of medicinal chemistry. 65(19)

مصطلحات موضوعية: Pyridazines, Structure-Activity Relationship, Receptors, Melanocortin, Drug Discovery, Molecular Medicine, Receptor, Melanocortin, Type 4, Cysteine, Xylenes, Peptides, Receptor, Melanocortin, Type 1, Melanocortins, Receptor, Melanocortin, Type 3

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a1ebcd561d0e46c4a7118ee9206de1Test
https://pubmed.ncbi.nlm.nih.gov/36167503Test

المؤلفون: Michelle N. Bedenbaugh, Samantha C. Brener, Jose Maldonado, Rachel N. Lippert, Patrick Sweeney, Roger D. Cone, Richard B. Simerly

المصدر: The Journal of comparative neurology. 530(16)

مصطلحات موضوعية: Male, Mice, Sex Characteristics, General Neuroscience, Hypothalamus, Animals, Brain, Female, Melanocortins, Receptor, Melanocortin, Type 3

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7004aa4c61585fe5a3fe01e1bbf2e72cTest
https://pubmed.ncbi.nlm.nih.gov/35770983Test

المؤلفون: Phaedra Geer, Marc A. Giulianotti, Skye R. Doering, Travis M. Lavoi, Mark D. Ericson, Radleigh Santos, Katie T. Freeman, Carrie Haskell-Luevano, Richard A. Houghten, Jon R. Appel, Ginamarie Debevec, Clemencia Pinilla

المصدر: J Med Chem

مصطلحات موضوعية: Agonist, endocrine system, Pyrrolidines, medicine.drug_class, Drug Evaluation, Preclinical, 01 natural sciences, Article, Pyrrolidine, Small Molecule Libraries, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Melanocortin receptor, Drug Discovery, medicine, Animals, Humans, Protein Isoforms, Receptor, Guanidine, 030304 developmental biology, Mice, Knockout, 0303 health sciences, integumentary system, digestive, oral, and skin physiology, Antagonist, Small molecule, Melanocortin 3 receptor, High-Throughput Screening Assays, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Biochemistry, Molecular Medicine, Melanocortin, Energy Metabolism, Algorithms, hormones, hormone substitutes, and hormone antagonists, Receptor, Melanocortin, Type 3

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9eb1c484c45bcbe6d841d2afad5501Test
https://doi.org/10.1021/acs.jmedchem.0c02041Test

المؤلفون: Luis E, Gimenez, Terry A, Noblin, Savannah Y, Williams, Satarupa, Mullick Bagchi, Ren-Lei, Ji, Ya-Xiong, Tao, Claus B, Jeppesen, Kilian W, Conde-Frieboes, Tomi K, Sawyer, Paolo, Grieco, Roger D, Cone

المصدر: Journal of medicinal chemistry. 65(8)

مصطلحات موضوعية: Structure-Activity Relationship, Alanine, HEK293 Cells, Receptors, Corticotropin, Humans, Ligands, Peptides, Melanocortins, Receptor, Melanocortin, Type 3

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::b869ec1cb5ff309b3585bd19864df3b4Test
https://pubmed.ncbi.nlm.nih.gov/35404053Test

المؤلفون: Yu-You, Du, Ming-Xing, Yao, Hui-Xia, Yu, Hao-Lin, Mo, Qi-Yuan, Yang, Jia-Jia, Yu, Li-Xin, Wang, Ji-Shu, Zhou, Yang, Li

المصدر: General and Comparative Endocrinology. 330:114149

مصطلحات موضوعية: Carps, Endocrinology, beta-MSH, Animals, Cosyntropin, Tissue Distribution, Animal Science and Zoology, Cloning, Molecular, Receptor, Melanocortin, Type 3

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f4ccb19658256c2d4690585b02225fTest
https://doi.org/10.1016/j.ygcen.2022.114149Test

المؤلفون: Stacey L. Wilber, Katlyn A. Fleming, Carrie Haskell-Luevano, Mary M. Lunzer, Danielle N. Adank, Mark D. Ericson, Zoe M Koeperich

المصدر: ACS Chem Neurosci

مصطلحات موضوعية: Agonist, medicine.medical_specialty, Physiology, medicine.drug_class, Cognitive Neuroscience, Population, Ligands, Biochemistry, Article, Energy homeostasis, Eating, Mice, 03 medical and health sciences, 0302 clinical medicine, Melanocortin receptor, Internal medicine, medicine, Animals, Homeostasis, education, Receptor, 030304 developmental biology, 0303 health sciences, education.field_of_study, Chemistry, Receptors, Melanocortin, Leptin, digestive, oral, and skin physiology, Cell Biology, General Medicine, Endocrinology, Receptor, Melanocortin, Type 4, Ghrelin, Melanocortin, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery, Receptor, Melanocortin, Type 3

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104e4d2d9e9fe36b34a6d903e803b669Test
https://doi.org/10.1021/acschemneuro.0c00409Test

المؤلفون: Xiaolu Tai, Xiaowei Lei, Qingfeng Li, Xiaozhu Wang, Yanbin Fu, Shen Qu, Cong Zhang, Yue Zhai, Chao Zhang, Diliqingna Dilimulati, Meng Wang, Liumei Lu, Yunpeng Li, Jing Xu

المصدر: Molecular Metabolism, Vol 53, Iss, Pp 101317-(2021)
Molecular Metabolism

مصطلحات موضوعية: Cell, Hypothalamus, Biology, MC4R, Single cell RNA-Seq, Energy homeostasis, Mice, GPCR, medicine, Animals, Humans, Receptor, Molecular Biology, Internal medicine, Cells, Cultured, G protein-coupled receptor, Cloning, MC3R, Cell Biology, RC31-1245, Melanocortins, Cell biology, HEK293 Cells, medicine.anatomical_structure, Receptor, Melanocortin, Type 4, Original Article, Signal transduction, Melanocortin, Dimerization, Function (biology), hormones, hormone substitutes, and hormone antagonists, Receptor, Melanocortin, Type 3, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8fdb9174e75c094a86319af6bfd82a3Test
http://www.sciencedirect.com/science/article/pii/S2212877821001642Test

المؤلفون: Lam, BYH, Williamson, A, Finer, S, Day, FR, Tadross, JA, Gonçalves Soares, A, Wade, K, Sweeney, P, Bedenbaugh, MN, Porter, DT, Melvin, A, Ellacott, KLJ, Lippert, RN, Buller, S, Rosmaninho-Salgado, J, Dowsett, GKC, Ridley, KE, Xu, Z, Cimino, I, Rimmington, D, Rainbow, K, Duckett, K, Holmqvist, S, Khan, A, Dai, X, Bochukova, EG, Genes & Health Research Team, Trembath, RC, Martin, HC, Coll, AP, Rowitch, DH, Wareham, NJ, Van Heel, DA, Timpson, N, Simerly, RB, Ong, KK, Cone, RD, Langenberg, C, Perry, JRB, Yeo, GS, O'Rahilly, S

المساهمون: Lam, BYH [0000-0002-3638-9025], Williamson, A [0000-0002-7599-9301], Finer, S [0000-0002-2684-4653], Day, FR [0000-0003-3789-7651], Tadross, JA [0000-0002-8424-1252], Wade, K [0000-0003-3362-6280], Porter, DT [0000-0002-8042-3251], Cimino, I [0000-0003-1397-5408], Holmqvist, S [0000-0001-6709-6666], Khan, A [0000-0002-5189-6906], Martin, HC [0000-0002-4454-9084], Rowitch, DH [0000-0002-0079-0060], Wareham, NJ [0000-0003-1422-2993], van Heel, DA [0000-0002-0637-2265], Timpson, N [0000-0002-7141-9189], Simerly, RB [0000-0001-5840-0152], Ong, KK [0000-0003-4689-7530], Cone, RD [0000-0003-3333-5651], Langenberg, C [0000-0002-5017-7344], Perry, JRB [0000-0001-6483-3771], Yeo, GS [0000-0001-8823-3615], O'Rahilly, S [0000-0003-2199-4449], Apollo - University of Cambridge Repository

مصطلحات موضوعية: Aged, 80 and over, Male, Menarche, Time Factors, Adolescent, Homozygote, Puberty, Hypothalamus, Nutritional Status, Estrous Cycle, Weight Gain, Melanocortins, Mice, Child Development, Phenotype, Animals, Humans, Female, Sexual Maturation, Insulin-Like Growth Factor I, Child, Receptor, Melanocortin, Type 3

وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fea96e53d6ebf5fbc07720240571134Test

المؤلفون: Hui Wang, Ze-Bin Jiang, Qiao Liu, Hao-Lin Mo, Yang Li, Li-Xin Wang, Hui-Xia Yu, Wei-Jia Song, Xin-Miao Zhang

مصطلحات موضوعية: Fish Proteins, endocrine system, animal structures, Physiology, General Medicine, Aquatic Science, Biology, Biochemistry, Melanocortin 3 receptor, alpha-MSH, Oncorhynchus mykiss, Animals, Rainbow trout, Amino Acid Sequence, Phylogeny, hormones, hormone substitutes, and hormone antagonists, Receptor, Melanocortin, Type 3

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f0be9f6a630d2103be611df7e6deddTest
https://doi.org/10.21203/rsTest.3.rs-507819/v1