Prediction of unfavorable outcomes in West Nile virus neuroinvasive infection - Result of a multinational ID-IRI study
| العنوان: | Prediction of unfavorable outcomes in West Nile virus neuroinvasive infection - Result of a multinational ID-IRI study |
|---|---|
| المؤلفون: | Arjan Harxhi, Nenad Pandak, Hüsnü Pullukçu, Selma Tosun, Antonio Cascio, Serkan Oncu, Éva Nagy, Olga Shmaylenko, Corneliu Petru Popescu, Mirjana Strbac, Simin Aysel Florescu, Jelena Djekic Malbasa, Rodrigo Hasbun, Emanoil Ceausu, Ilaria Coledan, Galina Gopatsa, Ami Neuberger, Hasip Kahraman, Simona Ruta, Botond Lakatos, Daniel Codreanu, Razi Evendar, Yasemin Cag, Hakan Erdem, Mihaela Zaharia, Gorana Dragovac, Natalia Pshenichnaya |
| المساهمون: | Ege Üniversitesi, Popescu C.P., Florescu S.A., Hasbun R., Harxhi A., Evendar R., Kahraman H., Neuberger A., Codreanu D., Zaharia M.F., Tosun S., Ceausu E., Ruta S.M., Dragovac G., Pshenichnaya N., Gopatsa G., Shmaylenko O., Nagy E., Malbasa J.D., Strbac M., Pandak N., Pullukcu H., Lakatos B., Cag Y., Cascio A., Coledan I., Oncu S., Erdem H. |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, West Nile virus, WNV, Meningitis, Encephalitis, Neuroinvasive, Death, medicine.medical_specialty, Internationality, 030106 microbiology, Disease, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, West Nile viru, Neuroinvasive disease, Central Nervous System Diseases, Predictive Value of Tests, Encephaliti, Virology, Internal medicine, medicine, Humans, Glasgow Coma Scale, 030212 general & internal medicine, Mortality, Aged, Retrospective Studies, Aged, 80 and over, Univariate analysis, business.industry, Mortality rate, Middle Aged, medicine.disease, Hospitalization, Meningiti, Infectious Diseases, Heart failure, Population Surveillance, Female, business, Tomography, X-Ray Computed, West Nile Fever |
| الوصف: | Background: WNV causes 1.4% of all central nervous system infections and is the most common cause of epidemic neuro-invasive disease in humans. Objectives: Our main objective was to investigate retrospectively West Nile virus neuroinvasive disease (WNND) cases hospitalized during 2010–2017 and identified factors that can influence prognosis. Study design: We documented the demographic, epidemiologic, clinical and laboratory data of WNND and identified factors that can influence prognosis. The data were recruited through Infectious Diseases International Research Initiative (ID-IRI), which serves as a network for clinical researches. Results: We investigated 165 patients with WNND in 10 countries from three continents. 27 patients died and the mortality rate was 16.4%. In an univariate analysis age, congestive heart failure, neoplasm and ischemic heart disease (p < 0.001), neuropsychiatric disorders (p = 0.011), chronic hepatitis (p = 0.024) and hypertension (p = 0.043) were risk factors for death. Fatal evolution was also correlated with ICU addmission, disorientation, speech disorders, change in consciousnes, coma, a low Glasgow coma score, obtundation, confusion (p < 0.001), history of syncope (p = 0.002) and history of unconsciousness (p = 0.037). In a binomial logistic regresssion analysis only age and coma remained independent prediction factors for death. We created an equation that was calculated according to age, co-morbidities and clinical manifestations that may be used to establish the prognosis of WNND patients. Conclusions: WNND remain an important factor for morbidity and mortality worldwide, evolution to death or survival with sequelae are not rare. Our study creates an equation that may be used in the future to establish the prognosis of WNND patients. © 2019 Elsevier B.V. PN-III-P1.2-PCCDI-2017-0005/2018 “The research of the Romanian patients was funded through CCCDI-UEFISCDI project PN-III-P1.2-PCCDI-2017-0005/2018, Romania.” |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b21df2236f6935f8663ce00d0ffb43cTest https://hdl.handle.net/11454/63060Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6b21df2236f6935f8663ce00d0ffb43c |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |