التفاصيل البيبلوغرافية
| العنوان: |
Pharmacotherapeutic Potential of Bitter Gourd (Momordica charantia) in Age-related Neurological Diseases. |
| المؤلفون: |
Hosseini Adarmanabadi, Seyed Mohammad Hosein, Khalil Abadi, Orod Jalali, Amiri, Amirhossein, Tamannaeifar, Rozhina, Balanian, Sahar, Rasekhjam, Mehdi, Samiazar, Mohammad Sadra, Hasanpour, Sara, Peiravi, Samira, Alijanzadeh, Dorsa, Poudineh, Mohadeseh, Amiri, Hamidreza, Mazhari, Seyed Amirhossein, Khademi, Reza, Deravi, Niloofar, Fathi, Mobina |
| المصدر: |
Journal of Integrative Neuroscience; 2024, Vol. 23 Issue 4, p1-17, 17p |
| مصطلحات موضوعية: |
MOMORDICA charantia, NEUROLOGICAL disorders, ALZHEIMER'S disease, TAU proteins, MINERAL supplements, ACETYLCHOLINESTERASE, OLDER people, MILD cognitive impairment |
| مستخلص: |
Due to the growth of the elderly population, age-related neurological disorders are an increasing problem. Aging begins very gradually and later leads to several neurological issues such as lower neurotransmitter levels, oxidative stress, neuronal inflammation, and continual neuronal loss. These changes might contribute to brain disorders such as Alzheimer's disease (AD), dementia or mild cognitive impairment, and epilepsy and glioma, and can also aggravate these disorders if they were previously present. Momordica charantia (bitter gourd), a member of the Cucurbitaceae family, is a good source of carbohydrates, proteins, vitamins, and minerals. It is used for diabetes and known for its hypoglycemic and antioxidant effects. In this review, we discuss the pharmaceutical effects of M. charantia on agerelated neurological disorders. We searched several databases, including PubMed and Google Scholar, using MeSH terms. We searched articles published up until 2022 regardless of publication language. M. charantia is rich in luteolin, which increases acetylcholine in neurons by binding to enzymes in acetylcholine metabolism pathways, including butyrylcholinesterase and acetylcholinesterase. This binding inhibits the hyperphosphorylation of tau protein by restraining its kinase enzyme. Furthermore, this substance can lower serum cholesterol and has multi-target activity in AD and memory loss. M. charantia can also improve memory by decreasing tau protein and it also has potent antioxidant activity and anti-inflammatory effects. This review highlights that M. charantia has effects on many age-related neurological disorders, and can be a cost-effective supplement with minimal side effects. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Integrative Neuroscience is the property of IMR Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder