التفاصيل البيبلوغرافية
| العنوان: |
Real-world evaluation of care for type 2 diabetes in Malaysia: A cross-sectional analysis of the treatment adherence to guideline evaluation in type 2 diabetes (TARGET-T2D) study |
| المؤلفون: |
Lim, Lee-Ling, Hussein, Zanariah, Noor, Nurain Md, Raof, Anis S. Abd, Mustafa, Norlaila, Bidin, Mohamed B. Long, Ghani, Rohana Abdul, Samsuddin, Syahrizan, Yong, Sy-Liang, Foo, Siew-Hui, Raghuram, Kavitha, Suwannasri, Payiarat, W. B., Wan Mohamad, Chiew, Thiam-Kian, Chan, Siew-Pheng |
| المساهمون: |
Ong, Hean Teik, Malaysian Endocrine and Metabolic Society |
| المصدر: |
PLOS ONE ; volume 19, issue 1, page e0296298 ; ISSN 1932-6203 |
| بيانات النشر: |
Public Library of Science (PLoS) |
| سنة النشر: |
2024 |
| المجموعة: |
PLOS Publications (via CrossRef) |
| الوصف: |
Aim Given a lack of data on diabetes care performance in Malaysia, we conducted a cross-sectional study to understand the clinical characteristics, control of cardiometabolic risk factors, and patterns of use of guideline-directed medical therapy (GDMT) among patients with type 2 diabetes (T2D), who were managed at publicly-funded hospitals between December 2021 and June 2022. Methods Patients aged ≥18 years with T2D from eight publicly-funded hospitals in the Greater Kuala Lumpur region, who had ≥2 outpatient visits within the preceding year and irrespective of treatment regimen, were eligible. The primary outcome was ≥2 treatment target attainment (defined as either HbA 1c <7.0%, blood pressure [BP] <130/80 mmHg, or low-density lipoprotein cholesterol [LDL-C] <1.8 mmol/L). The secondary outcomes were the individual treatment target, a combination of all three treatment targets, and patterns of GDMT use. To assess for potential heterogeneity of study findings, all outcomes were stratified according to prespecified baseline characteristics namely 1) history of atherosclerotic cardiovascular disease (ASCVD; yes/no) and 2) clinic type (Diabetes specialist versus General medicine). Results Among 5094 patients (mean±SD age 59.0±13.2 years; T2D duration 14.8±9.2 years; HbA 1c 8.2±1.9% (66±21 mmol/mol); BMI 29.6±6.2 kg/m 2 ; 45.6% men), 99% were at high/very high cardiorenal risk. Attainment of ≥2 treatment targets was at 18%, being higher in General medicine than in Diabetes specialist clinics (20.8% versus 17.5%; p = 0.039). The overall statin coverage was 90%. More patients with prior ASCVD attained LDL-C <1.4 mmol/L than those without (13.5% versus 8.4%; p<0.001). Use of sodium-glucose cotransporter-2 (SGLT2) inhibitors (13.2% versus 43.2%), glucagon-like peptide-1 receptor agonists (GLP1-RAs) (1.0% versus 6.2%), and insulin (27.7% versus 58.1%) were lower in General medicine than in Diabetes specialist clinics. Conclusions Among high-risk patients with T2D, treatment target attainment and use of ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1371/journal.pone.0296298 |
| الإتاحة: |
https://doi.org/10.1371/journal.pone.0296298Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.FB366C97 |
| قاعدة البيانات: |
BASE |
