دورية أكاديمية
High-dose-rate brachytherapy boost in prostate cancer: a New Zealand case series
| العنوان: | High-dose-rate brachytherapy boost in prostate cancer: a New Zealand case series |
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| المؤلفون: | Chin, John K. L., Rantshilane, Kenanao D., Chin, Paul K. L., Chaudhuri, Anupam, Tyrie, Leanne K., Hartopeanu, Cristian G. |
| المصدر: | Journal of Radiotherapy in Practice ; volume 15, issue 1, page 23-29 ; ISSN 1460-3969 1467-1131 |
| بيانات النشر: | Cambridge University Press (CUP) |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Oncology, Radiology, Nuclear Medicine and imaging |
| الوصف: | Aim The aim of the present study was to report the survival outcomes and late toxicity of high-dose-rate brachytherapy (HDRBT) boost for dose escalation in patients with intermediate-to-high-risk prostate cancer. Materials and methods Retrospective data were collected from 137 patients who had undergone definitive radiotherapy for prostate cancer between 2006 and 2010. All patients had external-beam radiotherapy (median dose 46Gy) and HDRBT. Brachytherapy dose was 19Gy in two fractions (6 hours apart) with one implant using Ir-192. Results There were 94 high-risk and 43 intermediate-risk patients (NCCN classification). The median follow-up period was 60 months. The 5-year biochemical progression-free survival was 92 and 76% for intermediate- and high-risk groups, respectively. Prostate cancer-specific survival for the intermediate-risk group was 100% and for the high-risk group it was 92% at 5 years. For the entire cohort, the 5-year rate of urethral stricture formation was 13%, and the 5-year rate of late grade 2 and grade 3 gastrointestinal toxicity was 4·7 and 4·6%, respectively. There was no grade 3 or greater genitourinary toxicity. Findings Our data add to the growing body of literature supporting the use of HDRBT in prostate cancer. Late toxicity rates were marginally higher than that expected. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1017/s1460396915000552 |
| الإتاحة: | https://doi.org/10.1017/s1460396915000552Test https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S1460396915000552Test |
| حقوق: | https://www.cambridge.org/core/termsTest |
| رقم الانضمام: | edsbas.59EE7B27 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1017/s1460396915000552 |
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