Bioassay-guided isolation of anti-inflammatory O-sulfated withanolides from Acnistus arborescens (Solanaceae)
| العنوان: | Bioassay-guided isolation of anti-inflammatory O-sulfated withanolides from Acnistus arborescens (Solanaceae) |
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| المؤلفون: | Carlos O. Morales, Clara Steinbrueck, Alfonso J. García-Piñeres, Juan J. Araya, Nohelia Mora-Ugalde, Randall Loiaza |
| المصدر: | Phytochemistry Letters, vol 29, pp. 190-194 Kérwá Universidad de Costa Rica instacron:UCR |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Sulfated withanolides, medicine.drug_class, Cytotoxicity, Acnistus arborescens, Plant Science, 01 natural sciences, Biochemistry, Anti-inflammatory, chemistry.chemical_compound, Sulfation, Ic50 values, medicine, Bioassay, Anti-inlammatory, biology, Traditional medicine, 010405 organic chemistry, biology.organism_classification, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Withaferin A, Agronomy and Crop Science, Solanaceae, Biotechnology |
| الوصف: | Bioassay-guided fractionation of Acnistus arborescens (Solanaceae) organic extract afforded two anti-inflammatory withanolides: 2,3-Dihydro-3β-O-sulfate withacnistin (1) and 2,3-Dihydro-3β-O-sulfate withaferin A (2) showing IC50 values of 1.0 ± 0.1 and 14 ± 1 μM respectively in a LPS-stimulated RAW 264.7 murine macrophage assay. These compounds were also evaluated against two selected cancer cell lines showing significant cytotoxicity. Although there are several reports dealing with the chemistry of this species, we report for the first time the isolation of O-sulfated withanolides. Universidad de Costa Rica/[ 801-B8-511]/UCR/Costa Rica UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM) UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Biología |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633278953b26ab0a27c5d3b6ee74fa75Test https://www.sciencedirect.com/science/article/pii/S1874390018302556Test#! |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....633278953b26ab0a27c5d3b6ee74fa75 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |