المؤلفون: Hellinen, Laura, Hongisto, Heidi, Ramsay, Eva, Kaarniranta, Kai, Vellonen, Kati Sisko, Skottman, Heli, Ruponen, Marika

المساهمون: Tampere University, BioMediTech

مصطلحات موضوعية: 318 Medical biotechnology

وصف الملف: fulltext

العلاقة: 184; https://trepo.tuni.fi/handle/10024/154889Test; URN:NBN:fi:tuni-202308117555

الإتاحة: https://doi.org/10.1016/j.ejpb.2023.01.026Test
https://trepo.tuni.fi/handle/10024/154889Test

المؤلفون: Ramsay, Eva, Lajunen, Tatu, Bhattacharya, Madhushree, Reinisalo, Mika, Rilla, Kirsi, Kidron, Heidi, Terasaki, Tetsuya, Urtti, Arto

المساهمون: Division of Pharmaceutical Biosciences, Drug Delivery Unit, Pharmaceutical Nanotechnology, Drug Research Program, Divisions of Faculty of Pharmacy, Drug Delivery

مصطلحات موضوعية: Cellular barrier, Choroid, Drug delivery, Drug target, Melanin, Pharmacokinetics, Receptor, Retina, Transporter, 317 Pharmacy

وصف الملف: application/pdf

العلاقة: Ramsay , E , Lajunen , T , Bhattacharya , M , Reinisalo , M , Rilla , K , Kidron , H , Terasaki , T & Urtti , A 2023 , ' Selective drug delivery to the retinal cells : Biological barriers and avenues ' , Journal of Controlled Release , vol. 361 . https://doi.org/10.1016/j.jconrel.2023.07.028Test; ORCID: /0000-0001-6427-8042/work/142859074; ORCID: /0000-0001-6234-9193/work/142859082; 74070654-39f9-4fa1-8bd5-830895756173; http://hdl.handle.net/10138/565363Test; 001048039700001

الإتاحة: http://hdl.handle.net/10138/565363Test

المؤلفون: Ramsay, Eva, Montaser, Ahmed B., Niitsu, Kanako, Urtti, Arto, Auriola, Seppo, Huttunen, Kristiina M., Uchida, Yasuo, Kidron, Heidi, Terasaki, Tetsuya

المصدر: Molecular Pharmaceutics; 7/1/2024, Vol. 21 Issue 7, p3204-3217, 14p

المؤلفون: Ramsay, Eva, Ravina, Manuela, Sarkhel, Sanjay, Hehir, Sarah, Cameron, Neil R., Ilmarinen, Tanja, Skottman, Heli, Kjems, Jørgen, Urtti, Arto, Ruponen, Marika, Subrizi, Astrid

المساهمون: Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, Tampere University

مصطلحات موضوعية: siRNA delivery, polyplex, lipoplex, lipidoid, retinal pigment epithelium, physiologically relevant RPE cell model, melanin, melanosome, Biolääketieteet - Biomedicine

وصف الملف: fulltext

العلاقة: 667; Pharmaceutics; 12; https://trepo.tuni.fi/handle/10024/123106Test; URN:NBN:fi:tuni-202009026870

الإتاحة: https://trepo.tuni.fi/handle/10024/123106Test

المؤلفون: Ramsay, Eva, Hagström, Marja, Vellonen, Kati-Sisko, Boman, Susanna, Toropainen, Elisa, del Amo, Eva M., Kidron, Heidi, Urtti, Arto, Ruponen, Marika

المساهمون: Division of Pharmaceutical Biosciences, Drug Delivery Unit, Drug Research Program

مصطلحات موضوعية: Retinal pigment epithelium, Intravitreal clearance, Ex vivo, Permeability, Bovine, Blood-retina barrier, Ocular pharmacokinetics, PREDICTION, INTRAVITREAL, CLEARANCE, Pharmacy

وصف الملف: application/pdf

العلاقة: We gratefully acknowledge grant funding from Academy of Finland (311122) (AU). We would like to thank Maija Lahtela-Kakkonen for helping with the logistics of the bovine eyes. Lea Pirskanen is acknowledged for her skilful technical assistance. This study was supported by Leo, Mary, and Mary-Ann Hackman Foundation (ER); The Finnish Cultural Foundation (ER); Orion Research Foundation (ER); European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie (grant No 799880) (EDA).; Ramsay , E , Hagström , M , Vellonen , K-S , Boman , S , Toropainen , E , del Amo , E M , Kidron , H , Urtti , A & Ruponen , M 2019 , ' Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation ' , European Journal of Pharmaceutics and Biopharmaceutics , vol. 143 , pp. 18-23 . https://doi.org/10.1016/j.ejpb.2019.08.008Test; ORCID: /0000-0001-6427-8042/work/63349977; http://hdl.handle.net/10138/318291Test; 3f9d95eb-0b51-40f5-a8e1-deba5ca55be2; 000488421000003

الإتاحة: http://hdl.handle.net/10138/318291Test

المؤلفون: Hellinen, Laura, Hongisto, Heidi, Ramsay, Eva, Kaarniranta, Kai, Vellonen, Kati-Sisko, Skottman, Heli, Ruponen, Marika

المساهمون: Drug Delivery Unit, Division of Pharmaceutical Biosciences, Drug Research Program

مصطلحات موضوعية: retinal pigment epithelium, outer blood-retinal barrier, cell models, drug permeation, differentiation, tight junctions, ocular drug delivery, PIGMENT EPITHELIUM, PLASMA-MEMBRANES, MELANIN BINDING, ARPE-19 CELLS, EXPRESSION, PERMEABILITY, PREDICTION, TISSUE, 317 Pharmacy

وصف الملف: application/pdf

العلاقة: This research was funded by the Academy of Finland (315085) and Finnish Cultural Foundation (L.H.).; Hellinen , L , Hongisto , H , Ramsay , E , Kaarniranta , K , Vellonen , K-S , Skottman , H & Ruponen , M 2020 , ' Drug Flux Across RPE Cell Models : The Hunt for An Appropriate Outer Blood-Retinal Barrier Model for Use in Early Drug Discovery ' , Pharmaceutics , vol. 12 , no. 2 , 176 . https://doi.org/10.3390/pharmaceutics12020176Test; a64ed159-7f11-46f4-b925-efec8d73752a; http://hdl.handle.net/10138/314142Test; 000519268500102

الإتاحة: http://hdl.handle.net/10138/314142Test

المؤلفون: Hellinen, Laura, Hongisto, Heidi, Ramsay, Eva, Kaarniranta, Kai, Vellonen, Kati-Sisko, Skottman, Heli, Ruponen, Marika

المصدر: European Journal of Pharmaceutics and Biopharmaceutics ; volume 184, page 181-188 ; ISSN 0939-6411

مصطلحات موضوعية: Pharmaceutical Science, General Medicine, Biotechnology

الإتاحة: https://doi.org/10.1016/j.ejpb.2023.01.026Test
https://api.elsevier.com/content/article/PII:S0939641123000310?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0939641123000310?httpAccept=text/plainTest

المؤلفون: Ramsay, Eva, Hagström, Marja, Vellonen, Kati Sisko, Boman, Susanna, Toropainen, Elisa, del Amo, Eva M., Kidron, Heidi, Urtti, Arto, Ruponen, Marika

المصدر: Ramsay , E , Hagström , M , Vellonen , K S , Boman , S , Toropainen , E , del Amo , E M , Kidron , H , Urtti , A & Ruponen , M 2019 , ' Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation ' , European Journal of Pharmaceutics and Biopharmaceutics , vol. 143 , pp. 18-23 . https://doi.org/10.1016/j.ejpb.2019.08.008Test

مصطلحات موضوعية: Blood-retina barrier, Bovine, Ex vivo, Intravitreal clearance, Ocular pharmacokinetics, Permeability, Retinal pigment epithelium

وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document

الإتاحة: https://doi.org/10.1016/j.ejpb.2019.08.008Test
https://research.manchester.ac.uk/en/publications/227dbf49-0590-44f2-8562-98a17464d2aaTest
https://pure.manchester.ac.uk/ws/files/158233921/Manuscript.pdfTest
https://pure.manchester.ac.uk/ws/files/149977200/Role_of_retinal_pigment_epithelium_permeability_Manuscript_revised_version.docxTest

المؤلفون: Ramsay, Eva, del Amo, Eva M., Toropainen, Elisa, Tengvall-Unadike, Unni, Ranta, Veli-Pekka, Urtti, Arto, Ruponen, Marika

المساهمون: Faculty of Pharmacy, Division of Pharmaceutical Biosciences, Drug Research Program, Drug Delivery, Drug Delivery Unit

مصطلحات موضوعية: Corneal permeability, Conjunctival permeability, Ocular drug delivery, Eye drops, Ocular absorption, Porcine, QSPR, TOPICALLY APPLIED PILOCARPINE, BETA-BLOCKING-AGENTS, QUANTITATIVE-EVALUATION, PENETRATION BEHAVIOR, PIGMENTED RABBIT, ABSORPTION, MODEL, DELIVERY, TIMOLOL, SCLERA, 317 Pharmacy

وصف الملف: application/pdf

العلاقة: Ramsay , E , del Amo , E M , Toropainen , E , Tengvall-Unadike , U , Ranta , V-P , Urtti , A & Ruponen , M 2018 , ' Corneal and conjunctival drug permeability: Systematic comparison and pharmacokinetic impact in the eye ' , European Journal of Pharmaceutical Sciences , vol. 119 , pp. 83-89 . https://doi.org/10.1016/j.ejps.2018.03.034Test; RIS: urn:166271B1049D03BA4A463175B6C94720; 85045384390; f342dd2a-4ed3-423a-993c-02c9417712e7; http://hdl.handle.net/10138/300635Test; 000432573700009

الإتاحة: http://hdl.handle.net/10138/300635Test

المؤلفون: Ramsay, Eva, Del Amo, Eva M, Toropainen, Elisa, Tengvall-Unadike, Unni, Ranta, Veli-Pekka, Urtti, Arto, Ruponen, Marika

المصدر: Ramsay , E , Del Amo , E M , Toropainen , E , Tengvall-Unadike , U , Ranta , V-P , Urtti , A & Ruponen , M 2018 , ' Corneal and conjunctival drug permeability : Systematic comparison and pharmacokinetic impact in the eye ' , European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences , vol. 119 , pp. 83-89 . https://doi.org/10.1016/j.ejps.2018.03.034Test

مصطلحات موضوعية: Animals, Aqueous Humor/metabolism, Biological Availability, Conjunctiva/blood supply, Cornea/metabolism, Permeability, Pharmaceutical Preparations/metabolism, Quantitative Structure-Activity Relationship, Regional Blood Flow, Swine

الإتاحة: https://doi.org/10.1016/j.ejps.2018.03.034Test
https://research.manchester.ac.uk/en/publications/54533db8-0b16-4a92-b6d2-142167291e0cTest