Triclosan and bisphenol a affect decidualization of human endometrial stromal cells
| العنوان: | Triclosan and bisphenol a affect decidualization of human endometrial stromal cells |
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| المؤلفون: | Sergio Rossi, Luigi Cobellis, Raffaella Specchio, Vincenza Laforgia, Verdiana Merafina, Maurizio Forte, Lavinia Mosca, D.G. Mita, Luigi Mita, Stefania Crispi, Maria De Falco, Maria Antonietta Castaldi |
| المساهمون: | Forte, Maurizio, Mita, Luigi, Cobellis, Luigi, Merafina, Verdiana, Specchio, Raffaella, Rossi, Sergio, Mita, Damiano Gustavo, Mosca, Lavinia, Castaldi, Maria Antonietta, DE FALCO, Maria, Laforgia, Vincenza, Crispi, Stefania, De Falco, Maria |
| المصدر: | Molecular and cellular endocrinology 422 (2016): 74–83. doi:10.1016/j.mce.2015.11.017 info:cnr-pdr/source/autori:Forte, Maurizio; Mita, Luigi; Cobellis, Luigi; Merafina, Verdiana; Specchio, Raffaella; Rossi, Sergio; Mita, Damiano Gustavo; Mosca, Lavinia; Castaldi, Maria Antonietta; De Falco, Maria; Laforgia, Vincenza; Crispi, Stefania/titolo:Triclosan and bisphenol a affect decidualization of human endometrial stromal cells./doi:10.1016%2Fj.mce.2015.11.017/rivista:Molecular and cellular endocrinology (Print)/anno:2016/pagina_da:74/pagina_a:83/intervallo_pagine:74–83/volume:422 |
| بيانات النشر: | Elsevier BV, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, endocrine system, medicine.medical_specialty, Stromal cell, Endocrine disrupting chemical, Environmental pollution, Endocrine Disruptors, Biology, Endometrium, Biochemistry, 03 medical and health sciences, Bisphenol A, 0302 clinical medicine, Endocrinology, Cell Movement, Internal medicine, Decidua, medicine, Humans, Endocrine system, IGFBP1, Endocrine disrupting chemicals, Endocrine Disruptor, Molecular Biology, Cells, Cultured, Progesterone, Cell Proliferation, 030219 obstetrics & reproductive medicine, urogenital system, Cell growth, Stromal Cell, Cell Cycle, Decidualization, Middle Aged, Cell cycle, Triclosan, Prolactin, Up-Regulation, Insulin-Like Growth Factor Binding Protein 1, 030104 developmental biology, medicine.anatomical_structure, Female, Stromal Cells, Human |
| الوصف: | In recent years, impaired fertility and endometrium related diseases are increased. Many evidences suggest that environmental pollution might be considered a risk factor for endometrial physiopathology. Among environmental pollutants, endocrine disrupting chemicals (EDCs) act on endocrine system, causing hormonal imbalance which, in turn, leads to female and male reproductive dysfunctions. In this work, we studied the effects of triclosan (TCL) and bisphenol A (BPA), two widespread EDCs, on human endometrial stromal cells (ESCs), derived from endometrial biopsies from woman not affected by endometriosis. Cell proliferation, cell cycle, migration and decidualization mechanisms were investigated. Treatments have been performed with both the EDCs separately or in presence and in absence of progesterone used as decidualization stimulus. Both TCL and BPA did not affect cell proliferation, but they arrested ESCs at G2/M phase of cell cycle enhancing cell migration. TCL and BPA also increased gene expression and protein levels of some decidualization markers, such as insulin growth factor binding protein 1 (IGFBP1) and prolactin (PRL), amplifying the effect of progesterone alone. All together, our data strongly suggest that TCL and BPA might alter human endometrium physiology so affecting fertility and pregnancy outcome. |
| تدمد: | 0303-7207 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf7ed778432a0defa05d6ae0813453bTest https://doi.org/10.1016/j.mce.2015.11.017Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9cf7ed778432a0defa05d6ae0813453b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03037207 |
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