دورية أكاديمية

Skin biopsy in adult patients with meningococcal purpura fulminans: a multicenter retrospective cohort study

التفاصيل البيبلوغرافية
العنوان: Skin biopsy in adult patients with meningococcal purpura fulminans: a multicenter retrospective cohort study
المؤلفون: Contou, Damien, Béduneau, Gaëtan, Rabault, Charlotte, Sonneville, Romain, Marchalot, Antoine, Coudroy, Rémi, Roux, Damien, Cour, Martin, Massol, Julien, Préau, Sébastien, de Prost, Nicolas, Pène, Frédéric, Colin, Gwenhaël, Barbier, François, Toufik, Kamel, Quelven, Quentin, Schnell, Guillaume, Ehrmann, Stephan, Messet, Hélène, Kimmoun, Antoine, Beuret, Pascal, Bruel, Cédric, Colling, Delphine, Conia, Alexandre, Martin, Luis Ensenyat, Reuter, Danielle, Das, Vincent, Challier, Marion, Jozwiak, Mathieu, Galbois, Arnaud, Fraisse, Mégan, Jaber, Samir, Jochmans, Sébastien, Kalfon, Pierre, Conrad, Marie, Lautrette, Alexandre, Darreau, Cédric, Lerolle, Nicolas, Georges, Hugues, Mégarbane, Bruno, Pichereau, Claire, Urbina, Tomas, Maury, Eric, Quenot, Jean-Pierre, Sauneuf, Bertrand, Schmidt, Matthieu, Valette, Xavier, Zafrani, Lara, da Silva, Daniel, Rigault, Guillaume, Woerther, Paul-Louis
المساهمون: Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)
المصدر: ISSN: 1364-8535.
بيانات النشر: HAL CCSD
BioMed Central
سنة النشر: 2023
المجموعة: Université de Montpellier: HAL
مصطلحات موضوعية: [SDV]Life Sciences [q-bio]
الوصف: International audience ; Abstract Background Neisseria meningitidis is the leading responsible bacterium of Purpura Fulminans (PF) accounting for two thirds of PF. Skin biopsy is a simple and minimally invasive exam allowing to perform skin culture and polymerase chain reaction (PCR) to detect Neisseria meningitidis . We aimed to assess the sensitivity of skin biopsy in adult patients with meningococcal PF. Methods A 17-year multicenter retrospective cohort study including adult patients admitted to the ICU for a meningococcal PF in whom a skin biopsy with conventional and/or meningococcal PCR was performed. Results Among 306 patients admitted for PF, 195 had a meningococcal PF (64%) with a skin biopsy being performed in 68 (35%) of them. Skin biopsy was performed in median 1 day after the initiation of antibiotic therapy. Standard culture of skin biopsy was performed in 61/68 (90%) patients and grew Neisseria meningitidis in 28 (46%) of them. Neisseria meningitidis PCR on skin biopsy was performed in 51/68 (75%) patients and was positive in 50 (98%) of them. Among these 50 positive meningococcal PCR, five were performed 3 days or more after initiation of antibiotic therapy. Finally, skin biopsy was considered as contributive in 60/68 (88%) patients. Identification of the meningococcal serogroup was obtained with skin biopsy in 48/68 (71%) patients. Conclusions Skin biopsy with conventional culture and meningococcal PCR has a global sensitivity of 88% and should be systematically considered in case of suspected meningococcal PF even after the initiation of antimicrobial treatment.
نوع الوثيقة: article in journal/newspaper
اللغة: English
العلاقة: hal-04092090; https://hal.science/hal-04092090Test; https://hal.science/hal-04092090/documentTest; https://hal.science/hal-04092090/file/2023%20Contou%20et%20al.,%20Skin%20biopsy.pdfTest
DOI: 10.1186/s13054-023-04461-2
الإتاحة: https://doi.org/10.1186/s13054-023-04461-2Test
https://hal.science/hal-04092090Test
https://hal.science/hal-04092090/documentTest
https://hal.science/hal-04092090/file/2023%20Contou%20et%20al.,%20Skin%20biopsy.pdfTest
حقوق: info:eu-repo/semantics/OpenAccess
رقم الانضمام: edsbas.1D9EA6E9
قاعدة البيانات: BASE