Antidiuretic hormone and the activation of glucose production during high intensity aerobic exercise
| العنوان: | Antidiuretic hormone and the activation of glucose production during high intensity aerobic exercise |
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| المؤلفون: | Nirubasini Paramalingam, Paul A. Fournier, Vinutha B Shetty, Elizabeth A. Davis, Timothy W. Jones, Heather C. Roby, Grant J. Smith |
| المصدر: | Metabolism Open Metabolism Open, Vol 11, Iss, Pp 100113-(2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Vasopressin, Physiology, Antidiuretic hormone, Endogeny, QD415-436, SE, Standard error, Blood glucose level, Biochemistry, Internal medicine, medicine, BGL, Blood glucose levels, Aerobic exercise, QP1-981, Ra, Rate of glucose appearance, Glucose production, High intensity exercise, ADH, Antidiuretic hormone, Morning, Type 1 diabetes, business.industry, Repeated measures design, T1D, Type 1 diabetes, medicine.disease, Original Research Paper, Endocrinology, AVP, ADH, Arginine vasopressin, V̇O2peak, Peak rate of oxygen consumption, business, Antidiuretic, Hormone |
| الوصف: | Objective This study aimed to investigate the role that antidiuretic hormone (ADH) may play in the activation of glucose production during high intensity aerobic exercise. Materials/methods This study was part of larger study based on a repeated measures cross-over study design and involved ten adult participants who exercised in the morning at 80 % V̇O2peak for up to 40 min or until exhaustion. During and after exercise, the participants were subjected to a morning euglycaemic/euinsulinaemic clamp while [6,6-2H2]glucose was infused and blood sampled to measure the endogenous rate of glucose appearance (Ra) and ADH levels. Results The levels of plasma ADH were 1.8 ± 0.2 pmol/L (mean ± SEM) at rest and increased to 10.5 ± 2.1 pmol/L at the end of exercise (mean ± SEM), which lasted 8.5–40 min. In response to exercise, glucose Ra also rose significantly (p Highlights • Intense aerobic exercise in T1D causes a significant increase in plasma ADH level and endogenous glucose production rate. • This study raises the possibility of a causal relationship between these variables during intense exercise in humans. • The role of ADH in activation of endogenous glucose production during intense exercise warrants further investigations. |
| اللغة: | English |
| تدمد: | 2589-9368 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff1ec4a7b8f88a29a36b32510aabf88Test http://europepmc.org/articles/PMC8333141Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7ff1ec4a7b8f88a29a36b32510aabf88 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25899368 |
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