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المؤلفون: Giulia I. Corsi, Kunli Qu, Ferhat Alkan, Xiaoguang Pan, Yonglun Luo, Jan Gorodkin
المصدر: Corsi, G I, Qu, K, Alkan, F, Pan, X, Luo, Y & Gorodkin, J 2022, ' CRISPR/Cas9 gRNA activity depends on free energy changes and on the target PAM context ', Nature Communications, vol. 13, 3006 . https://doi.org/10.1038/s41467-022-30515-0Test
Corsi, G I, Qu, K, Alkan, F, Pan, X, Luo, Y & Gorodkin, J 2022, ' CRISPR/Cas9 gRNA activity depends on free energy changes and on the target PAM context ', Nature Communications, vol. 13, no. 1, 3006 . https://doi.org/10.1038/s41467-022-30515-0Testمصطلحات موضوعية: Genome, Multidisciplinary, General Physics and Astronomy, General Chemistry, CRISPR-Cas Systems, RNA, Guide/genetics, General Biochemistry, Genetics and Molecular Biology, RNA, Guide, Kinetoplastida
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e29800189ea77ae64d3b55d513203d2Test
https://doi.org/10.1038/s41467-022-30515-0Test -
2دورية أكاديمية
المؤلفون: Bratlie, Sigrid
المصدر: Genialt. 26(3):12
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المؤلفون: de Jong, Olivier G, Murphy, Daniel E, Mäger, Imre, Willms, Eduard, Garcia-Guerra, Antonio, Gitz-Francois, Jerney J, Lefferts, Juliet, Gupta, Dhanu, Steenbeek, Sander C, van Rheenen, Jacco, El Andaloussi, Samir, Schiffelers, Raymond M, Wood, Matthew J A, Vader, Pieter, Afd Pharmaceutics, Pharmaceutics
المساهمون: Afd Pharmaceutics, Pharmaceutics
المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications, 11(1). Nature Publishing Groupمصطلحات موضوعية: 0301 basic medicine, Cell, General Physics and Astronomy, Membrane trafficking, Cell Communication, 0302 clinical medicine, Genes, Reporter, CRISPR, Guide RNA, lcsh:Science, Multidisciplinary, Chemistry, Extracellular Vesicles/genetics, Extracellular vesicle, Non-coding RNA, Publisher Correction, Endocytosis, 3. Good health, Cell biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, RNA, Guide, Kinetoplastida, Science, Guide/genetics, RNA, Guide/genetics, General Biochemistry, Genetics and Molecular Biology, Article, Fluorescence, Cell Line, Reporter/genetics, 03 medical and health sciences, Extracellular Vesicles, Genes, Reporter/genetics, medicine, Humans, Gene, RNA, Small Untranslated/genetics, Assay systems, Small Untranslated/genetics, RNA, Biological Transport, Endocytosis/genetics, General Chemistry, 030104 developmental biology, HEK293 Cells, Genes, RNA, Small Untranslated, Nanoparticles, lcsh:Q, CRISPR-Cas Systems
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96795276f8b51089cc73b9e0f0bcf265Test
https://doaj.org/article/1db2023ed1d94f558ace5b4d70bad252Test -
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المؤلفون: Guillermo Montoya, Tillmann Pape, Simon Erlendsson, Stefano Stella, Anders Fuglsang, Piero Temperini, Nicholas Sofos, Arturo Carabias
المصدر: Nature Communications
Carabias, A, Fuglsang, A, Temperini, P, Pape, T, Sofos, N, Stella, S, Erlendsson, S & Montoya, G 2021, ' Structure of the mini-RNA-guided endonuclease CRISPR-Cas12j3 ', Nature Communications, vol. 12, 4476 . https://doi.org/10.1038/s41467-021-24707-3Test
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)مصطلحات موضوعية: Models, Molecular, CRISPR-Cas systems, Protein Conformation, Science, CRISPR-Associated Proteins, General Physics and Astronomy, CRISPR-Associated Proteins/chemistry, Computational biology, RNA, Guide/genetics, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, chemistry.chemical_compound, Endonuclease, 0302 clinical medicine, Protein structure, Genome editing, Catalytic Domain, Bacteriophages/enzymology, CRISPR, Bacteriophages, DNA Cleavage, 030304 developmental biology, Trans-activating crRNA, Gene Editing, 0303 health sciences, Multidisciplinary, Endodeoxyribonucleases, biology, Escherichia coli Proteins, Mutagenesis, Cryoelectron Microscopy, RNA, General Chemistry, RNA, Viral/genetics, Endodeoxyribonucleases/chemistry, chemistry, Escherichia coli Proteins/chemistry, biology.protein, Mutagenesis, Site-Directed, RNA, Viral, CRISPR-Cas Systems, Structural biology, 030217 neurology & neurosurgery, DNA, RNA, Guide, Kinetoplastida
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380dfd70481600acb8e2ab65f51df601Test
http://europepmc.org/articles/PMC8298400Test -
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المؤلفون: S. Shareef, Victoria Harding, C B T Moore, Kathleen A. Christie, Kevin Blighe, Thomais Kakouli-Duarte, Leandro Castellano, Justin Stebbing, Bo L. Chawes, Rachel S. Kelly, M A Nesbit, Connie Chao-Shern, Jessica Lasky-Su, Larry DeDionisio
المصدر: BMC Genomics, Vol 19, Iss 1, Pp 1-20 (2018)
Blighe, K, DeDionisio, L, Christie, K A, Chawes, B, Shareef, S, Kakouli-Duarte, T, Chao-Shern, C, Harding, V, Kelly, R S, Castellano, L, Stebbing, J, Lasky-Su, J A, Nesbit, M A & Moore, C B T 2018, ' Gene editing in the context of an increasingly complex genome ', BMC Genomics, vol. 19, no. 1, pp. 595 . https://doi.org/10.1186/s12864-018-4963-8Test
BMC Genomicsمصطلحات موضوعية: 0301 basic medicine, lcsh:QH426-470, Genomic complexity, lcsh:Biotechnology, epigenome, complex genetics, Context (language use), Computational biology, Review, Biology, sequencing technology development, Gene editing, ENCODE, RNA, Guide/genetics, Genome, integrated omics, 03 medical and health sciences, Epigenome, Genome editing, lcsh:TP248.13-248.65, Genetics, CRISPR, Humans, 1000 Genomes Project, genome, Gene Editing/methods, Cas9, gene editing, Genome, Human, genomic complexity, Genetic Variation, Integrated omics, Complex genetics, enviroCORE - IT Carlow, lcsh:Genetics, 030104 developmental biology, Sequencing technology development, Human genome, Genetic Engineering, Transcriptome, transcriptome, Biotechnology, RNA, Guide, Kinetoplastida
وصف الملف: application/pdf; PDF
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d3fcd835b3bd37b0a7f074c584badfTest
http://link.springer.com/article/10.1186/s12864-018-4963-8Test -
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المؤلفون: João Amorim, José Bessa, Renata Bordeira-Carriço, Ana Gali-Macedo, Chiara Perrod
المساهمون: Instituto de Investigação e Inovação em Saúde
المصدر: STAR Protocols
STAR Protocols, Vol 1, Iss 3, Pp 100208-(2020)مصطلحات موضوعية: animal structures, Microinjections, Gene Editing / methods, ved/biology.organism_classification_rank.species, Zebrafish / genetics, Sequence Deletion / genetics, Mutagenesis (molecular biology technique), Genomics, Computational biology, General Biochemistry, Genetics and Molecular Biology, Genome engineering, 03 medical and health sciences, 0302 clinical medicine, Model Organisms, Protocol, Genetics, CRISPR, Animals, RNA, Guide / genetics, lcsh:Science (General), Model organism, Microinjections / methods, Zebrafish, Sequence Deletion, 030304 developmental biology, Gene Editing, Cloning, 0303 health sciences, Genome, General Immunology and Microbiology, biology, ved/biology, Cas9, General Neuroscience, CRISPR-Cas Systems / physiology, biology.organism_classification, 3. Good health, Mutagenesis, Site-Directed / methods, Mutagenesis, Site-Directed, CRISPR-Cas Systems, Genetic Engineering, Genetic Engineering / methods, 030217 neurology & neurosurgery, RNA, Guide, Kinetoplastida, lcsh:Q1-390
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49184fd730cbbb7e73f1e52d9e18e2e4Test
https://hdl.handle.net/10216/145275Test -
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المؤلفون: Natasha Lopes Fischer, Rashad Mammadov, Stefan Bekiranov, Hayrunnisa Unlu, Turan Tufan, Cem Kuscu, Mazhar Adli, Sevki Arslan, Masato T. Kanemaki, Agnes Czikora
المصدر: Journal of molecular biology. 431(1)
مصطلحات موضوعية: CRISPR-Associated Proteins, EP300 protein, human, K-562 cell line, CRISPR Cas system, 0302 clinical medicine, histone H3, Structural Biology, CRISPR, RNA, Guide, genetics, Clustered Regularly Interspaced Short Palindromic Repeats, Promoter Regions, Genetic, non-regulatory regions, Regulation of gene expression, Gene Editing, 0303 health sciences, biology, messenger RNA, gene control, gene expression regulation, Chromatin, Histone, priority journal, HEK293 cell line, enhancer region, RNA, Guide, Kinetoplastida, octamer transcription factor 4, E1A associated p300 protein, HEK293T cell line, p300, Computational biology, Article, Cell Line, CRISPR-Associated Proteins/*genetics, CRISPR-Cas Systems/*genetics, Clustered Regularly Interspaced Short Palindromic Repeats/*genetics, E1A-Associated p300 Protein/*genetics, Gene Editing/*methods, Gene Expression Regulation, HEK293 Cells, Humans, Promoter Regions, Genetic/genetics, RNA, Guide/genetics, 03 medical and health sciences, CRISPR associated protein, promoter region, Epigenome editing, MyoD1 protein, controlled study, Epigenetics, AID (auxin-inducible degron), human, procedures, Enhancer, Molecular Biology, 030304 developmental biology, enhancer-like elements, epigenetics, human cell, Epigenome, guide RNA, biology.protein, chromatin, CRISPR-Cas Systems, auxin, mammal cell, E1A-Associated p300 Protein, 030217 neurology & neurosurgery, clustered regularly interspaced short palindromic repeat
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3162e4123e128e44c4adb6a91a18b072Test
https://pubmed.ncbi.nlm.nih.gov/30098338Test -
8Tuning dCas9's ability to block transcription enables robust, noiseless knockdown of bacterial genes
المؤلفون: Lun Cui, Enno R. Oldewurtel, Sven van Teeffelen, Antoine Vigouroux, David Bikard
المساهمون: Biologie de Synthèse - Synthetic biology, Institut Pasteur [Paris] (IP), Morphogénèse et Croissance microbiennes / Microbial Morphogenesis and Growth, This work was supported by the European Research Council (ERC) under the Europe Union's Horizon 2020 research and innovation program [Grant Agreement No. (677823) to DB and No. (679980) to SvT], the French Government's Investissement d'Avenir program Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious Diseases' (ANR‐10‐LABX‐62‐IBEID) to SvT, DB, and AV, the Marie de Paris 'Emergence(s)' program and the Volkswagen Foundation to SvT, and the Pasteur‐Weizmann consortium to DB., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), European Project: 677823,H2020,ERC-2015-STG,CRISPAIR(2016), European Project: 679980,H2020,ERC-2015-STG,RCSB(2016), Institut Pasteur [Paris]
المصدر: Molecular Systems Biology
Molecular Systems Biology, 2018, 14 (3), pp.e7899. ⟨10.15252/msb.20177899⟩
Molecular Systems Biology, EMBO Press, 2018, 14 (3), pp.e7899. ⟨10.15252/msb.20177899⟩مصطلحات موضوعية: 0301 basic medicine, MESH: CRISPR-Cas Systems, Cell morphology, single‐cell, MESH: RNA, Guide/genetics, chemistry.chemical_compound, Transcription (biology), RNA polymerase, Gene expression, Gene Knockdown Techniques, Guide RNA, Promoter Regions, Genetic, Quantitative Biology & Dynamical Systems, Gene knockdown, gene-expression noise, MESH: Gene Expression Regulation, Bacterial, Applied Mathematics, Articles, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Computational Theory and Mathematics, MESH: Genes, Bacterial, General Agricultural and Biological Sciences, Transcription, RNA, Guide, Kinetoplastida, Information Systems, Transcriptional Activation, gene‐expression noise, MESH: Bacteria/genetics, Computational biology, Biology, Article, General Biochemistry, Genetics and Molecular Biology, CRISPR‐dCas9, 03 medical and health sciences, MESH: Promoter Regions, Genetic, Gene, Bacteria, General Immunology and Microbiology, CRISPR-dCas9, CRISPRi, Gene Expression Regulation, Bacterial, single-cell, MESH: Gene Knockdown Techniques, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, peptidoglycan cell wall, 030104 developmental biology, chemistry, Genes, Bacterial, MESH: Transcriptional Activation, CRISPR-Cas Systems, Synthetic Biology & Biotechnology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9d3bb78cc58edd6f7687eb8ad78ee6Test
https://hal-pasteur.archives-ouvertes.fr/pasteur-01967521Test -
9مورد إلكتروني
المصدر: Corsi , G I , Qu , K , Alkan , F , Pan , X , Luo , Y & Gorodkin , J 2022 , ' CRISPR/Cas9 gRNA activity depends on free energy changes and on the target PAM context ' , Nature Communications , vol. 13 , 3006 .
مصطلحات الفهرس: CRISPR-Cas Systems, Genome, RNA, Guide/genetics, article
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10مورد إلكتروني
المصدر: Corsi , G I , Qu , K , Alkan , F , Pan , X , Luo , Y & Gorodkin , J 2022 , ' CRISPR/Cas9 gRNA activity depends on free energy changes and on the target PAM context ' , Nature Communications , vol. 13 , 3006 .
مصطلحات الفهرس: CRISPR-Cas Systems, Genome, RNA, Guide/genetics, article
