المؤلفون: Leon P. Loevenich, Thomas Engleitner, Marlies Michl, Sebastian Vosberg, Matjaz Rokavec, Andreas Jung, Heiko Hermeking, Philipp A. Greif, Jens Neumann, Jörg Kumbrink, Roland Rad, Thomas Kirchner, Peter Jung, Rupert Öllinger, Sophie L. Boos

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 517-540 (2022)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: Colorectal cancer, EdU, 5-ethynyl-2’-deoxyuridine, RNP, ribonucleoprotein, Cetuximab, RC799-869, DMSO, dimethyl sulfoxide, medicine.disease_cause, MEK, mitogen-activated protein/extracellular signal-regulated kinase kinase, eKRAS, clustered regularly interspaced short palindromic repeats/Cas9-generated KRASG12D, PDTO, patient-derived tumor organoid, PCR, polymerase chain reaction, ERK, extracellular signal-regulated kinase, GSEA, gene set enrichment analysis, IC50, half-maximal inhibitory concentration, CT-PDTO, chemotherapy-adapted patient-derived tumor organoid, 5’-FU, 5-fluorouracil, Medicine, E2F1, Epidermal growth factor receptor, ANOVA, analysis of variance, Original Research, Aurora Kinase A, biology, TOC, tumor organoid culture, Liver Neoplasms, Gastroenterology, AfaSel, afatinib + selumetinib, FOLFIRI, folinic acid, Combination chemotherapy, Diseases of the digestive system. Gastroenterology, ADF, advanced Dulbecco’s modified Eagle medium/F12, FFPE, formalin-fixed paraffin-embedded, Organoids, CRISPR, clustered regularly interspaced short palindromic repeats, CRC, colorectal cancer, FOLFIRI, Cas9, CRISPR-associated 9 protein, 5’-FU, irinotecan (or SN-38), KRAS, Colorectal Neoplasms, SN-38, irinotecan active metabolite, Chemoresistance, medicine.drug, AURKA, Aurora kinase A, CRC Organoid, c-MYC, c-MYC oncogene, cDNA, complementary DNA, Cmab, cetuximab, E2F, E2 transcription factor, RAS, rat sarcoma viral oncogene homolog, 3D, 3-dimensional, Humans, MSI, microsatellite instable, UMI, unique molecular identifier, EGF, epidermal growth factor, HER, human epithelial growth factor receptor, Hepatology, business.industry, PARP, poly-adenosine diphosphate ribose polymerase, LMU, Ludwig-Maximilians-University, medicine.disease, digestive system diseases, EGFR, epidermal growth factor receptor, Cancer research, biology.protein, TCGA, The Cancer Genome Atlas, business, MAPK, mitogen-activated protein kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230937cfbfdbfc2312a8988f38a35f08Test
http://www.sciencedirect.com/science/article/pii/S2352345X21002228Test

المؤلفون: Poupak Fallahi, Valeria Mazzi, Roberto Vita, Silvia Martina Ferrari, Gabriele Materazzi, David Galleri, Salvatore Benvenga, Paolo Miccoli, Alessandro Antonelli

المصدر: International Journal of Molecular Sciences, Vol 16, Iss 3, Pp 6153-6182 (2015)

مصطلحات موضوعية: dedifferentiated thyroid cancer, radioiodine, papillary thyroid carcinoma, RET (REarranged during Transfection), BRAF (B-Raf proto-oncogene, serine/threonine kinase), RAS (Rat Sarcoma), vascular endothelial growth factor receptor 2, vandetanib, cabozantinib, sorafenib, Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: http://www.mdpi.com/1422-0067/16/3/6153Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/abae97fe4bc649ee875d853bf40c7795Test

المؤلفون: Hong-Min Liu, Ya-Hong Wu, Yihui Song, Min Zhao, Bin Yu

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 750-762 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PMSF, phenylmethanesulfonyl fluoride, LS, LEOPARD syndrome, Mutant, IC50, half maximal inhibitory concentration, Protein tyrosine phosphatase, HTS, high-throughput screening, chemistry.chemical_compound, 0302 clinical medicine, DiFMUP, 6,8-difluoro-4-methylumbelliferyl phosphate, General Pharmacology, Toxicology and Pharmaceutics, AML, acute myelogenous leukemia, Tm, melting temperature, 0303 health sciences, LB, lysogeny broth, SDS-PAGE, sodium dodecyl sulphate polyacyrlamide gel electrophoresis, High-throughput screening, R2, coefficient of determination, S/B, signal over background, STAT, signal transducer and activator of transcription, SHP2, Src homology phosphotyrosyl phosphatase 2, Biochemistry, 030220 oncology & carcinogenesis, Original Article, BTLA, B and T lymphocyte attenuator, PTP, protein tyrosine phosphatase, SH2, Src homology 2, Proto-oncogene tyrosine-protein kinase Src, Thermal shift assay, Allosteric regulation, Phosphatase, JAK, janus kinase, AKT, protein kinase B, SHP2-WT, wild type Src homology phosphotyrosyl phosphatase 2, SHP2-PTP, protein tyrosine phosphatase domain of Src homology phosphotyrosyl phosphatase 2, 03 medical and health sciences, PI3K, phosphatidylinositol 3 kinase, NS, Noonan syndrome, RAS, rat sarcoma, FI, fluorescence intensity, NPC, no protein control, 030304 developmental biology, ΔTm, melting temperature change, DiFMU, 6,8-difluoro-4-methylumbelliferyl hydroxid, ALK, anaplastic lymphoma kinase, lcsh:RM1-950, HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, MEK, extracellular regulated protein kinase kinases, JMML, juvenile myelomonocytic leukaemia, Enzyme assay, PD-1, programmed death 1, p-IRS1, phosphorylated insulin receptor substrate 1, Bis-tris, bis-(2-hydroxyethyl)amino-tris(hydroxymethyl)methane, OD, optical density, lcsh:Therapeutics. Pharmacology, chemistry, DTT, dithiothreitol, SHP2, Allosteric inhibitors, Bioisostere, LOC, ligand only control, SD, standard deviation, MAPK, mitogen-activated protein kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114cd1e4de1acb4de79002f71ffaa0beTest
https://doi.org/10.1016/j.apsb.2020.10.021Test

المؤلفون: Luigi Ricciardiello, Giulia Piazzi, Chiara Alquati, Anna Prossomariti

المساهمون: Prossomariti A., Piazzi G., Alquati C., Ricciardiello L.

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 491-506 (2020)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, Colorectal cancer, Wnt/β-Catenin, Resistance, FZD, frizzled, mTORC1, Review, PI3K, phosphatidylinositol-3-kinase, DEPTOR, DEP domain-containing mTOR-interacting protein, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, GTPase, guanosine triphosphatase, Antineoplastic Combined Chemotherapy Protocols, Crosstalk, beta Catenin, Phosphoinositide-3 Kinase Inhibitors, Kinase, Gastroenterology, Wnt signaling pathway, mTORC1, mammalian target of rapamycin complex 1, APC, adenomatous polyposis coli, eIF4E, eukaryotic translation initiation factor 4E, FOXO3A, Forkhead box O3A, MNK, Mitogen-activated Protein kinase interacting kinases, Gene Expression Regulation, Neoplastic, Crosstalk (biology), PI3K/AKT/mTORC1, CRC, colorectal cancer, PORCN, Porcupine, 030211 gastroenterology & hepatology, Colorectal Neoplasms, RAS, Rat Sarcoma, Signal Transduction, Rheb, ras homolog enriched in brain, TSC, tuberous sclerosis, 4E-BP1, 4E binding protein 1, mTOR, mammalian target of rapamycin, RNF43, ring finger protein 43, Biology, Mechanistic Target of Rapamycin Complex 1, TNKSi, tankyrase inhibitors, AKT, protein kinase B, 03 medical and health sciences, eEF2K, elongation factor 2 kinase, MEK, Mitogen-activated protein kinase kinase, Cell Line, Tumor, medicine, GSK3, glycogen synthase kinase 3, Animals, Humans, FAP, familial adenomatous polyposis, lcsh:RC799-869, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, TNKS, tankyrase, Colorectal Cancer, Hepatology, ZNRF3, zinc/ring finger 3, medicine.disease, YAP, Yes-associated protein, EGFR, epidermal growth factor receptor, Wnt Proteins, Disease Models, Animal, 030104 developmental biology, DVL, Dishevelled, Drug Resistance, Neoplasm, Catenin, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, Proto-Oncogene Proteins c-akt, LRP, low-density lipoprotein receptors 5 and 6, S6K, S6 Kinase

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7a306ac692719a8347e0c547725351Test
http://www.sciencedirect.com/science/article/pii/S2352345X20300515Test

المؤلفون: Johanna McChord, Katharina Ganss, Christian Krautz, Sebastian Hempel, Klaus-Peter Knoch, Michele Solimena, Robert Grützmann, Philippe Ravassard, Kamal Chowdhury, Jürgen Weitz, Stephan Kersting, Christian Pilarsky, Hassan Mziaut, Steffen Wolk, Georg Henniger

المساهمون: Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Technische Universität Dresden = Dresden University of Technology (TU Dresden), Max-Planck-Institut für Biophysikalische Chemie - Max Planck Institute for Biophysical Chemistry [Göttingen], Max-Planck-Gesellschaft, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)

المصدر: Molecular metabolism
Molecular metabolism, Elsevier, 2020, 31, pp.150-162. ⟨10.1016/j.molmet.2019.11.012⟩
Molecular Metabolism, Vol 31, Iss, Pp 150-162 (2020)
Molecular Metabolism
Mol. Metab. 31, 150-162 (2020)

مصطلحات موضوعية: Male, 0301 basic medicine, Pten, phosphatase and tensin homolog, Pi3k, phosphatidylinositol-4,5-bisphosphate 3-kinase, Apoptosis, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], miR-132, microRNA 132, miR-132, Creb, cAMP response element-binding protein, BrdU, bromodeoxyuridine, Mice, 0302 clinical medicine, Insulin-Secreting Cells, miRNA, microRNA, Raf, rapidly accelerated fibrosarcoma, Cells, Cultured, Mice, Knockout, Gene knockdown, Forkhead Box Protein O3, FOXO3, Original Article, β cell regeneration, Beta cell, Signal Transduction, lcsh:Internal medicine, Cell Survival, T2D, type 2 diabetes, 030209 endocrinology & metabolism, Biology, Fgfr3, fibroblast growth factor receptor 3, GSIS, glucose-stimulated insulin secretion, 03 medical and health sciences, RT-PCR, reverse transcription polymerase chain reaction, Pancreatectomy, Nras, neuroblastoma RAS viral oncogene homolog, Downregulation and upregulation, Pten/Akt/Foxo3a, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], microRNA, Animals, Humans, PTEN, Gnb, G protein subunit beta, lcsh:RC31-1245, Molecular Biology, Protein kinase B, Gnb1, G protein subunit beta 1, IPA, Ingenuity Pathway Analysis, Cell Proliferation, Mir-132, Beta Cell Regeneration, Pten/akt/foxo3a, pHH3, phosphohistone H3, Mapk1, mitogen-activated protein kinase 1, PTEN Phosphohydrolase, Cell Biology, LCM, laser capture microscopy, Mice, Inbred C57BL, MicroRNAs, HEK293 Cells, 030104 developmental biology, Ras, rat sarcoma, Pik3r1, phosphoinositide-3 kinase regulatory subunit 1, Akt, protein kinase B, Cancer research, biology.protein, Foxo3a, Forkhead box O3a, Sos1, Son of Sevenless homolog 1, Proto-Oncogene Proteins c-akt

وصف الملف: application/pdf; application/zip

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac233ce670f178447662777e657c669Test
https://doi.org/10.1016/j.molmet.2019.11.012Test

المؤلفون: Christoph Wittich, Claus A. M. Seidel, Radovan Dvorsky, Soheila Rezaei Adariani, Farhad Bazgir, Ehsan Amin, Mohammad Reza Ahmadian, Neda S. Kazemein Jasemi

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, RIT, RAS-like protein expressed in many tissues, GTPase-activating protein, HRAS, Harvey rat sarcoma, GTPase, RALA, RAS-like protein A, RASD, dexamethasone-induced RAS-related, Biochemistry, protein interactions, RA, RAS association domain, RB, RAS-binding domain, NORE-1, GAP, GTPase-activating protein, ERK, extracellular signal-regulated kinase, GTP, guanosine triphosphate, GTPase, guanosine triphosphatase, RASSF, RAS association domain family, RAF, rapidly accelerated fibrosarcoma, biology, PLCε, phospholipase C epsilon, RAS association domain, HK1, hexokinase-1, RIN, RAS and RAB interactor, CR domain, cysteine-rich domain, RALA, TIAM, T-lymphoma invasion and metastasis protein, RERGL, RAS-related and estrogen-regulated growth inhibitor-like protein, RHEB, RAS homologous enriched in brain, RAP, RAS proximate, Guanine nucleotide exchange factor, PI3K, phosphoinositide 3-kinase, RHEB, Research Article, effectors, Protein Binding, Signal Transduction, SHANK, SH3 and multiple ankyrin repeat domain, RHO, RAS homologous, RGS, regulator of G protein signaling, AF6, ALL1-fused gene from chromosome 6, Computational biology, PDZGEF, PDZ-domain-containing guanine nucleotide exchange factor, Protein–protein interaction, GEF, guanine nucleotide exchange factor, 03 medical and health sciences, Regulator of G protein signaling, RRAS, RAS-related protein, NKIRAS, NF-kappa-B inhibitor-interacting RAS-like protein, NRAS, neuroblastoma RAS, PKC, protein kinase C, RAS, rat sarcoma, RERG, RAS-related and estrogen-regulated growth inhibitor, Humans, Protein Interaction Domains and Motifs, HRAS, SIN1, stress-activated protein kinase-interacting protein 1, Molecular Biology, RALGDS, RAL guanine nucleotide dissociation stimulator, KRAS, Kristen rat sarcoma, 030102 biochemistry & molecular biology, SARAH, Salvador–RASSF–Hippo domain, Tumor Suppressor Proteins, Computational Biology, Cell Biology, NORE1, novel RAS effector, RAS-binding domain, 030104 developmental biology, HEK293 Cells, MBP, maltose binding protein, RGL, RAL guanine nucleotide dissociation stimulator-like, MEK, MAPK/ERK kinase, biology.protein, ras Proteins, RASSF5, SNX17, sorting nexin-17, RASSF1, Apoptosis Regulatory Proteins, RASSF, MAPK, mitogen-activated protein kinase, RAS

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c908bf66f01ab88e26b2531338812873Test
http://europepmc.org/articles/PMC8163975Test

المؤلفون: Gilbert J. Cote, Nguyet Minh Hoang, Oorvashi Roy Puli, Marie Claude Hofmann, Heather E. Danysh, Elena McBeath, Brian P. Danysh, Maria E. Cabanillas, Deepankar K. Sinha, Reid T. Powell

المصدر: Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 11, Pp 1121-1134 (2018)
Neoplasia (New York, N.Y.)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, endocrine system diseases, BRAF, v-Raf murine sarcoma viral oncogene homolog B (or B-RAF), ERK, extracellular signal-regulated kinase (or mitogen-activated protein kinase 1), hTERT, human telomerase reverse transcriptase, Papillary thyroid cancer, PI3K, phosphatidylinositol-4, 5-bisphosphate 3-kinase, 0302 clinical medicine, Cell Movement, ETS, E26 transformation-specific (or E-twenty-six), Thyroid cancer, Regulation of gene expression, ATC, anaplastic thyroid carcinoma, PDTC, poorly differentiated papillary thyroid carcinoma, Nuclear Proteins, AKT, protein kinase B (or PKB), lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunohistochemistry, TERT, telomerase reverse transcriptase, 3. Good health, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Thyroid Cancer, Papillary, TSH, thyroid stimulating hormone, 030220 oncology & carcinogenesis, Mitogen-Activated Protein Kinases, EMT, epithelial-mesenchymal transition, RAS, rat-sarcoma (gene family), Signal Transduction, Proto-Oncogene Proteins B-raf, Original article, Epithelial-Mesenchymal Transition, ETV5, ETS translocation variant 5 (or ERM), mTOR, mammalian target of rapamycin, PEA3, polyoma enhancer activator 3, Biology, lcsh:RC254-282, MAPK pathway, mitogen-activated protein kinase pathway, 03 medical and health sciences, Cell Line, Tumor, medicine, Humans, SOS, son of sevenless, Epithelial–mesenchymal transition, GRB2, growth factor receptor-bound protein 2, Transcription factor, PI3K/AKT/mTOR pathway, Cell Proliferation, Twist-Related Protein 1, RAF, rapidly accelerated fibrosarcoma (gene family), TGFBR, transforming growth factor receptor, medicine.disease, 030104 developmental biology, PTC, papillary thyroid carcinoma, Tumor progression, Mutation, Cancer research, Biomarkers, MEK, mitogen-activated protein kinase kinase (or MAP2K, MAPKK), V600E, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca0dc81b99cd04b707e47e050584981Test
http://www.sciencedirect.com/science/article/pii/S1476558618304299Test

المؤلفون: Ivan Silbern, Henning Urlaub, Reinhard Jahn, Kuan-Ting Pan, Stefan Bonn, Maksims Fiosins, Silvio O. Rizzoli, Eugenio F. Fornasiero

المصدر: Molecular & Cellular Proteomics : MCP
Molecular and Cellular Proteomics
Molecular & cellular proteomics 20, 100061-(2021). doi:10.1016/j.mcpro.2021.100061

مصطلحات موضوعية: Botulinum Toxins, CK1, casein kinase 1, SNAP-25, synaptosomal-associated protein, 25kDa, Syntaxin 1, synaptobrevin, CLK, SRPK1 and Clk/Sty protein kinase, Biochemistry, CREB1, CAMP-responsive element binding protein 1, PAK, p21-activated kinase, Analytical Chemistry, SV, synaptic vesicle, AAV, adeno-associated virus, Receptor, Cannabinoid, CB1, TEAB, triethylammonium bicarbonate buffer, Clostridium botulinum, Syntaxin, metabolism [Calcium], metabolism [Syntaxin 1], NMDAR, N-methyl-d-aspartate receptor, metabolism [Phosphoproteins], Neurons, 0303 health sciences, AGC, automatic gain control, 030302 biochemistry & molecular biology, pharmacology [Neurotoxins], STE, “sterile” serine/threonine protein kinases, Endocytosis, Cell biology, DAPK, death-associated protein kinase, metabolism [Neurons], SNARE, RT, room temperature, GRK, G-protein-coupled receptor kinase, GluDH, glutamate dehydrogenase, Synaptic vesicle, Exocytosis, 03 medical and health sciences, PKC, protein kinase C, Humans, Rats, Wistar, Molecular Biology, metabolism [Synaptic Vesicles], metabolism [Glutamic Acid], CAA, chloroacetamide, cytology [Hippocampus], CaMKII, calcium-calmodulin kinase 2, MAPK, mitogen-activated protein kinase, HeLa Cells, ITR, inverted terminal repeat (sequence), Proteome, SNARE, N-ethylmaleimide-sensitive factor-attachment protein receptors, BoNT, botulinum neurotoxin, Hippocampus, R-SNARE Proteins, synapse, botulinum neurotoxins, Protein phosphorylation, POI, protein of interest, Phosphorylation, bRP, basic reversed-phase chromatography, CDK, cyclin-dependent kinase, FA, formic acid, TFE, trifluoroethanol, Voltage-dependent calcium channel, Chemistry, Depolarization, PP1, protein phosphatase 1, metabolism [Receptor, Cannabinoid, CB1], AMPAR, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, Synaptic Vesicles, exocytosis, syntaxin, TCEP, tris(2-carboxyethyl)phosphine, Neurotoxins, PNGase F, peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase, Glutamic Acid, AMPA receptor, Neurotransmission, phosphomimetic studies, pharmacology [Botulinum Toxins], GSK3, glycogen synthase kinase 3, Animals, AGC, protein kinase A, G, C kinase group, ddc:610, metabolism [Synaptosomes], 030304 developmental biology, GO, gene ontology, metabolism [R-SNARE Proteins], Research, cannabinoid receptor, ACN, acetonitrile, Phosphoproteins, CK2, casein kinase 2, RAS, rat sarcoma gene, Calcium, AP, action potential, CMGC, CDK, MAP, GSK, CDKL kinase group, GABA, γ-aminobutyric acid, Synaptosomes

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d93635b9e859a1023882c0903a6342Test
https://pubmed.ncbi.nlm.nih.gov/33582301Test

المؤلفون: Xiao-Feng Xiong, Yang Sun, Xue Ping Chen, Zhendong Song, Ziyang Xu, Yang Ge, Meijing Wang

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 13-29 (2021)

مصطلحات موضوعية: PDAC, pancreatic ductal adenocarcinoma, STAT, signal transducers and activators of transcription, RAS, rat sarcoma protein, Protein tyrosine phosphatase, Review, TIGIT, T-cell immunoglobulin and ITIM domain protein, SCC, squamous cell carcinoma, B-ALL, B-cell acute lymphoblastic leukemia, SCNA, somatic copy number change, 0302 clinical medicine, KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, Selectivity, CTLA-4, cytotoxic T lymphocyte-associated antigen-4, General Pharmacology, Toxicology and Pharmaceutics, Tyrosine, GAB2, Grb2-associated binding protein-2, PD-1/PDL-1, programmed cell death protein-1/programmed death ligand-1, AML, acute myeloid leukemia, 0303 health sciences, PTK, protein tyrosine kinase, Chemistry, SHP2, Src homology containing protein tyrosine phosphatase 2, TKIs, tyrosine kinase inhibitors, 030220 oncology & carcinogenesis, Tumor therapy, JAK, Janus kinase, BTLA, B and T lymphocyte attenuator, PTP, protein tyrosine phosphatase, RTKs, receptor tyrosine kinase inhibitors, Proto-oncogene tyrosine-protein kinase Src, Allosteric inhibitor, Phosphatase, Allosteric regulation, CSF-1, colony stimulating factor-1, Tumor targeted, 03 medical and health sciences, PI3K, phosphatidylinositol 3 kinase, TYROSINE PHOSPHATASE SHP2, SAR, structure–activity relationship, ERK1/2, extracelluar signal-regulated kinase 1/2, SBDD, structure-based drug design, GRB2, growth factor receptor-bound protein 2, PDX, patient-derived xenograft, 030304 developmental biology, FLT3, Fms-like tyrosine kinase-3, ALK, anaplastic lymphoma kinase, lcsh:RM1-950, Bioavailability, EGFR, epidermal growth factor receptor, CADD, computer aided drug design, lcsh:Therapeutics. Pharmacology, HGF/SF, hepatocyte growth factor/scatter factor, NLRP3, NLR family, pyrin domain containing protein 3, HER2, human epidermal growth factor receptor-2, Cancer research, SHP2, MAPK, mitogen-activated protein kinase, hERG, human ether-a-go-go-related gene

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377d61b2602a59fd7130cd6ded70715cTest
https://pubmed.ncbi.nlm.nih.gov/33532178Test

المؤلفون: Jaw-Yuan Wang, Wei-Chih Su, Hsiang-Lin Tsai, Hsiu-Chung Cheng, Tsung-Kun Chang

المصدر: Translational Oncology, Vol 14, Iss 7, Pp 101089-(2021)
Translational Oncology

مصطلحات موضوعية: Oncology, endocrine system diseases, TCF4, Transcription factor 4, Colorectal cancer, RR, relative risk, Review, I2, I-square, HbA1c, Hemoglobin A1c, ADM, antidiabetic medications, AGEs, advanced glycation end-products, SMAD3, Mothers against decapentaplegic homolog 3, US, United States, Impaired glucose tolerance, ADA, American Diabetes Association, Diabetes mellitus, 0302 clinical medicine, GREM1, Gremlin 1, SEPT9, septin 9, RC254-282, APC, Adenomatous polyposis coli, pCR, pathologic complete response, RFS, recurrence-free survival, Metformin, 030220 oncology & carcinogenesis, CRC, colorectal cancer, TCF7L2, Transcription Factor 7 Like 2, medicine.medical_specialty, CSCs, cancer stem cells, WNT, Wingless-related integration site, mTOR, mammalian target of rapamycin, BMI, Body mass index, GLUT1, glucose transporter 1, STZ, streptozotocin, EHMT2, Euchromatic Histone Lysine Methyltransferase 2, VEGFR2, vascular endothelial growth factor 2, mCRC, metastatic colorectal cancer, 03 medical and health sciences, NIDDM, non-insulin-dependent diabetes mellitus, PFS, Progression-free survival, ERFC, Emerging Risk Factors Collaboration, PKC, protein kinase C, KRAS, Kirsten rat sarcoma viral oncogene homolog, AKT, RAC-alpha serine/threonine-protein kinase, WFS1, Wolframin ER Transmembrane Glycoprotein, IGF, Insulin-Like Growth Factor, nutritional and metabolic diseases, medicine.disease, PPARG, Peroxisome Proliferator Activated Receptor Gamma, 030104 developmental biology, Hyperglycemia, TCF7L2, Oncological outcome, 0301 basic medicine, Cancer Research, TP53, tumor protein p53, FOLFOX, Folinic acid, Fluorouracil, Oxaliplatin, RPG, random plasma glucose, Cancer risk, DNA, deoxyribonucleic acid, DM, diabetes mellitus, HNF1B, Hepatocyte nuclear factor-1-beta, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, HR, hazard ratios, CENTRAL, Cochrane Central Register of Controlled Trials, GWAS, Genome-wide association studies, IGF1, Insulin-Like Growth Factor 1, HBP, hexosamine biosynthetic pathway, medicine.drug, PI3K, Phosphoinositide 3-kinases, KCNQ1, Potassium Voltage-Gated Channel Subfamily Q Member 1, EMT, epithelial mesenchymal transition, CAMK1D, Calcium/Calmodulin Dependent Protein Kinase ID, TTR, the time to recurrence, 2-h PG, 2-h plasma glucose, OS, overall survival, ROS, reactive oxygen species, IGFBPs, insulin-like growth factor-binding protein, Internal medicine, RAS, Rat sarcoma, medicine, FPG, fasting plasma glucose, PI3K/AKT/mTOR pathway, VTI1A, Vesicle Transport Through Interaction With T-SNAREs 1A, U.S.FDA, United States Food and Drug administration, OGTT, Oral Glucose Tolerance Test, business.industry, IGF2BP2, Insulin Like Growth Factor 2 MRNA Binding Protein 2, ACF, aberrant crypt foci, AMPK, Cancer, BMJ, British Medical Journal, CI, confidence interval, OR, odds ratio, AMPK, AMP-activated protein kinase, DKD, diabetic kidney disease, TP53INP1, Tumor Protein P53 Inducible Nuclear Protein 1, 5-FU, 5-fluorouracil, NEJM, The New England Journal of Medicine, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b748b9c71d9b30a48c845ddaf0de4297Test
https://doi.org/10.1016/j.tranon.2021.101089Test