دورية أكاديمية
Clinical phenotypes of IgG4-related disease: an analysis of two international cross-sectional cohorts
| العنوان: | Clinical phenotypes of IgG4-related disease: an analysis of two international cross-sectional cohorts |
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| المؤلفون: | Wallace, Zachary S, Zhang, Yuqing, Perugino, Cory A, Naden, Ray, Choi, Hyon K, Stone, John H, Akamizu T, Akiyama M, Bateman A, Blockmans D, Brito-Zeron P, Campochiaro C, Carruthers M, Chari S, Chiba T, Choi H, Fernandez Codina A, Cornell L, Culver E, Della-Torre E, Deshpande V, Dicaire JF, Dong L, Ebbo M, A Ferry J, Fragkoulis G, Frost F, Frulloni L, A Hart P, Hernandez-Molina G, Inoue D, Keat K, Kamisawa T, Kawa S, Kawano M, Khosroshahi A, Kobayashi H, Kodama Y, Kubo S, Kubota K, Lanzillotta M, Lerch MM, Liu Y, Löhr M, Marvisi C, Martinez-Valle F, Martin-Nares E, Masaki Y, Matsui S, Mizushima I, P Naden R, Nakamura S, Nordeide J, Notohara K, Okazaki K, Paira S, A Perugino C, Popovic J, Ramos-Casals M, Rosenbaum J, Ryu J, Sato Y, Sharma A, Saeki T, Sekiguchi H, Schleinitz N, V Sokol E, H Stone J, R Stone J, Takahashi H, Takahashi N, Takahira M, Tanaka Y, Umehara H, Vaglio A, Villamil A, Wada Y, S Wallace Z, Webster G, Yamada K, Yamamoto M, Yi J, Zamboni G, Zen Y, Zhang W. |
| المساهمون: | Wallace, Zachary S, Zhang, Yuqing, Perugino, Cory A, Naden, Ray, Choi, Hyon K, Stone, John, H, Akamizu, T, Akiyama, M, Bateman, A, Blockmans, D, Brito-Zeron, P, Campochiaro, C, Carruthers, M, Chari, S, Chiba, T, Choi, H, Fernandez Codina, A, Cornell, L, Culver, E, Della-Torre, E, Deshpande, V, Dicaire, Jf, Dong, L, Ebbo, M, A Ferry, J, Fragkoulis, G, Frost, F, Frulloni, L, A Hart, P, Hernandez-Molina, G, Inoue, D, Keat, K, Kamisawa, T, Kawa, S, Kawano, M, Khosroshahi, A, Kobayashi, H, Kodama, Y, Kubo, S, Kubota, K, Lanzillotta, M, Lerch, Mm, Liu, Y, Löhr, M, Marvisi, C, Martinez-Valle, F, Martin-Nares, E, Masaki, Y, Matsui, S, Mizushima, I, P Naden, R, Nakamura, S, Nordeide, J, Notohara, K, Okazaki, K, Paira, S, A Perugino, C, Popovic, J, Ramos-Casals, M, Rosenbaum, J, Ryu, J, Sato, Y, Sharma, A, Saeki, T, Sekiguchi, H, Schleinitz, N, V Sokol, E, H Stone, J, R Stone, J, Takahashi, H, Takahashi, N, Takahira, M, Tanaka, Y, Umehara, H, Vaglio, A, Villamil, A, Wada, Y, S Wallace, Z, Webster, G, Yamada, K, Yamamoto, M, Yi, J, Zamboni, G, Zen, Y, Zhang, W. |
| سنة النشر: | 2019 |
| المجموعة: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| مصطلحات موضوعية: | IgG4-related disease, cluster analysi, epidemiology, Adult, America, Aortiti, Asia, Asian Continental Ancestry Group, Continental Population Group, Cross-Sectional Studie, Digestive System Disease, Europe, Female, Human, Immunoglobulin G, Immunoglobulin G4-Related Disease, Male, Middle Aged, Mikulicz' Disease, Otorhinolaryngologic Disease, Phenotype, Retroperitoneal Fibrosis |
| الوصف: | Objective I gG4-related disease (IgG4-RD) is a heterogeneous, multiorgan condition of unclear aetiology that can cause organ failure. Difficulty recognising IgG4-RD contributes to diagnostic delays. We sought to identify key IgG4-RD phenotypes.Methods We used two cross-sectional studies assembled by an international, multispecialty network of IgG4-RD specialists who submitted 765 cases to derive and replicate phenotypic groups. Phenotype groups of disease manifestations and key covariate distributions across the identified groups were measured using latent class analysis.Results In the derivation cohort (n=493), we identified four groups with distinct manifestations: Group 1 (31%), Pancreato-Hepato-Biliary disease; Group 2 (24%), Retroperitoneal Fibrosis and/or Aortitis; Group 3 (24%), Head and Neck-Limited disease and Group 4 (22%), classic Mikulicz syndrome with systemic involvement. We replicated the identification of four phenotype groups in the replication cohort. Compared with cases in Groups 1, 2 and 4, respectively, cases in Group 3 were more likely to be female (OR 11.60 (95% CI 5.39 to 24.98), 10.35 (95% CI 4.63 to 23.15) and 9.24 (95% CI 3.53 to 24.20)) and Asian (OR 6.68 (95% CI 2.82 to 15.79), 7.43 (95% CI 2.97 to 18.56) and 6.27 (95% CI 2.27 to 17.29)). Cases in Group 4 had a higher median serum IgG4 concentration (1170 mg/dL) compared with groups 1-3 (316, 178 and 445 mg/dL, respectively, p<0.001).Conclusion We identified four distinctive IgG4-RD phenotypes according to organ involvement. Being Asian or female may predispose individuals to head and neck-limited disease. These phenotypes serve as a framework for identifying IgG4-RD and studying its aetiology and optimal treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30612117; info:eu-repo/semantics/altIdentifier/wos/WOS:000471061000020; volume:78; issue:3; firstpage:406; lastpage:412; numberofpages:7; journal:ANNALS OF THE RHEUMATIC DISEASES; http://hdl.handle.net/11562/1015651Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85059659885 |
| DOI: | 10.1136/annrheumdis-2018-214603 |
| الإتاحة: | https://doi.org/10.1136/annrheumdis-2018-214603Test http://hdl.handle.net/11562/1015651Test |
| رقم الانضمام: | edsbas.30743363 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/annrheumdis-2018-214603 |
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