المؤلفون: Beetham, Henry, Griffith, Billie G. C., Murina, Olga, Loftus, Alexander E. P., Parry, David A., Temps, Carolin, Culley, Jayne, Muir, Morwenna, Unciti-Broceta, Asier, Sims, Andrew H., Byron, Adam, Brunton, Valerie G.

المصدر: Beetham , H , Griffith , B G C , Murina , O , Loftus , A E P , Parry , D A , Temps , C , Culley , J , Muir , M , Unciti-Broceta , A , Sims , A H , Byron , A & Brunton , V G 2022 , ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ' , Cancer Research , vol. 82 , no. 4 , pp. 632-647 . https://doi.org/10.1158/0008-5472.CAN-21-0373Test

مصطلحات موضوعية: Aniline Compounds/pharmacology, Animals, Breast Neoplasms/enzymology, Cell Line, Tumor, Cell Proliferation/drug effects, Female, Gene Expression Profiling/methods, Gene Expression Regulation, Neoplastic, Gene Knockout Techniques, Humans, Kaplan-Meier Estimate, MCF-7 Cells, Mice, Knockout, Nitriles/pharmacology, Protein Kinase Inhibitors/pharmacology, Protein Serine-Threonine Kinases/genetics, Quinolines/pharmacology, Signal Transduction/drug effects, Xenograft Model Antitumor Assays/methods, src-Family Kinases/antagonists & inhibitors

العلاقة: https://research.manchester.ac.uk/en/publications/11f89f31-67bf-4164-b15e-5158da2d6cf6Test

الإتاحة: https://doi.org/10.1158/0008-5472.CAN-21-0373Test
https://research.manchester.ac.uk/en/publications/11f89f31-67bf-4164-b15e-5158da2d6cf6Test

المساهمون: Takuji Okusaka, Kenji Ikeda, Masatoshi Kudo, Richard Finn, Shukui Qin, Kwang-Hyub Han, Ann-Lii Cheng, Fabio Piscaglia, Masahiro Kobayashi, Max Sung, Minshan Chen, Lucjan Wyrwicz, Jung-Hwan Yoon, Zhenggang Ren, Kalgi Mody, Corina Dutcus, Toshiyuki Tamai, Min Ren, Seiichi Hayato, Hiromitsu Kumada, Han, Kwang Hyup

مصطلحات موضوعية: Adult, Aged, 80 and over, Antineoplastic Agents / adverse effects, Antineoplastic Agents / pharmacology, Antineoplastic Agents / therapeutic use, Body Weight / drug effects, Carcinoma, Hepatocellular / drug therapy, Dose-Response Relationship, Drug, Female, Humans, Liver Neoplasms / complications, Liver Neoplasms / drug therapy, Male, Middle Aged, Phenylurea Compounds / adverse effects, Phenylurea Compounds / pharmacology, Phenylurea Compounds / therapeutic use, Quinolines / adverse effects, Quinolines / pharmacology, Quinolines / therapeutic use, Sorafenib / adverse effects, Sorafenib / pharmacology, Sorafenib / therapeutic use, Treatment Outcome, Body weight, Dosing, Hepatocellular carcinoma

العلاقة: JOURNAL OF GASTROENTEROLOGY; J01416; OAK-2022-04247; https://ir.ymlib.yonsei.ac.kr/handle/22282913/190430Test; T202126062; JOURNAL OF GASTROENTEROLOGY, Vol.56(6) : 570-580, 2021-06

الإتاحة: https://doi.org/10.1007/s00535-021-01785-0Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190430Test

المؤلفون: Lang, Fabian, Wunderle, Lydia, Badura, Susanne, Schleyer, Eberhard, Brüggemann, Monika, Serve, Hubert, Schnittger, Susanne, Gökbuget, Nicola, Pfeifer, Heike, Wagner, Sebastian, Ashelford, Kevin, Bug, Gesine, Ottmann, Oliver G.

المصدر: http://lobid.org/resources/99370676275806441Test#!, 21(1):70.

مصطلحات موضوعية: Aged, 80 and over [MeSH], Aged [MeSH], PI3K/mTor inhibition, Transcription Factors/genetics [MeSH], Antineoplastic Agents/pharmacology [MeSH], Imidazoles/pharmacokinetics [MeSH], Phase I clinical trial, Proto-Oncogene Proteins c-akt/genetics [MeSH], Quinolines/pharmacology [MeSH], Leukemia/metabolism [MeSH], BEZ235, Male [MeSH], Phosphoinositide-3 Kinase Inhibitors/pharmacokinetics [MeSH], Phosphoinositide-3 Kinase Inhibitors/therapeutic use [MeSH], Leukemia/drug therapy [MeSH], Phosphoinositide-3 Kinase Inhibitors/pharmacology [MeSH], Research Article, Drug Resistance, Neoplasm [MeSH], Imidazoles/pharmacology [MeSH], Female [MeSH], Quinolines/therapeutic use [MeSH], Adult [MeSH], TOR Serine-Threonine Kinases/antagonists, Humans [MeSH], Treatment Outcome [MeSH], Leukemia/genetics [MeSH], PTEN Phosphohydrolase/genetics [MeSH], Middle Aged [MeSH]

العلاقة: https://repository.publisso.de/resource/frl:6452350Test; https://doi.org/10.1186/s40360-020-00446-xTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523358Test/

الإتاحة: https://doi.org/10.1186/s40360-020-00446-xTest
https://repository.publisso.de/resource/frl:6452350Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523358Test/

المؤلفون: Awada, Rayan, Verdier, Dorothée, Froger, Solène, Brulard, Eric, de Faria Maraschin, Simone, Etienne, Hervé, Breton, David

المساهمون: UMR - Interactions Plantes Microorganismes Environnement (UMR IPME), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD France-Sud ), Département Systèmes Biologiques (Cirad-BIOS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)

المصدر: ISSN: 2045-2322.

مصطلحات موضوعية: Somatic embryogenesis, Coffee, High throughput optimization, Automated screening system, Active compounds, MESH: Automation, Laboratory, MESH: Coffea / cytology, MESH: Quinolines / pharmacology, MESH: Reproducibility of Results, MESH: Seeds / cytology, MESH: Seeds / drug effects, MESH: Seeds / growth & development, MESH: Coffea / drug effects, MESH: Hight-Throughput Screening Assays / instrumentation, MESH: Hight-Throughput Screening Assays / methods, MESH: Histone Deacetylase inhibitors / pharmacology, MESH: Hydroxamic Acids / pharmacology, MESH: Hydroxylamines / pharmacology, MESH: Miniaturization, MESH: Pilot Projects, MESH: Plant Cells / drug effects, MESH: Plant Somatic Embryogenesis Techniques / methods, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31965007; hal-03454869; https://hal.umontpellier.fr/hal-03454869Test; https://hal.umontpellier.fr/hal-03454869/documentTest; https://hal.umontpellier.fr/hal-03454869/file/s41598-020-57800-6.pdfTest; PUBMED: 31965007; PUBMEDCENTRAL: PMC6972844; WOS: 000512142100048

الإتاحة: https://doi.org/10.1038/s41598-020-57800-6Test
https://hal.umontpellier.fr/hal-03454869Test
https://hal.umontpellier.fr/hal-03454869/documentTest
https://hal.umontpellier.fr/hal-03454869/file/s41598-020-57800-6.pdfTest

المساهمون: Hee Jin Kim, Hanna Cho, Seongbeom Park, Hyemin Jang, Young Hoon Ryu, Jae Yong Choi, Seung Hwan Moon, Seung Jun Oh, Minyoung Oh, Duk L. Na, Chul Hyoung Lyoo, Eun-Joo Kim, William W. Seeley, Jae Seung Kim, Kyung Chan Choi, Sang Won Seo, Lyoo, Chul Hyoung

مصطلحات موضوعية: Aged, Aminopyridines/pharmacology, Autopsy, Brain/diagnostic imaging, Brain/pathology, Carbolines/pharmacology, Creutzfeldt-Jakob Syndrome/diagnostic imaging, Creutzfeldt-Jakob Syndrome/pathology, Humans, Male, Monoamine Oxidase/metabolism, Neurofibrillary Tangles/pathology, Positron-Emission Tomography/methods, Quinolines/pharmacology, tau Proteins/metabolism, Creutzfeldt-Jakob disease, Flortaucipir PET, Monoamine oxidase B, THK5351 PET

وصف الملف: application/pdf

العلاقة: BMC NEUROLOGY; J00368; OAK-2019-05717; https://ir.ymlib.yonsei.ac.kr/handle/22282913/173303Test; T201904454; BMC NEUROLOGY, Vol.19(1) : 211, 2019; 63870

الإتاحة: https://doi.org/10.1186/s12883-019-1434-zTest
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173303Test

المؤلفون: Laforge, M, Silvestre, R, Rodrigues, V, Garibal, J, Campillo-Gimenez, L, Mouhamad, S, Monceaux, V, Cumont, M, Rabezanahary, H, Pruvost, A, Cordeiro-da-Silva, A, Hurtrel, B, Silvestri, G, Senik, A, Estaquier, J

المساهمون: Instituto de Investigação e Inovação em Saúde

مصطلحات موضوعية: Acquired Immunodeficiency Syndrome / drug therapy, Acquired Immunodeficiency Syndrome / enzymology, Acquired Immunodeficiency Syndrome / pathology, Amino Acid Chloromethyl Ketones / pharmacology, Animals, CD4-CD8 Ratio, CD4-Positive T-Lymphocytes / enzymology, CD4-Positive T-Lymphocytes / pathology, Caspase Inhibitors / pharmacology, Disease Progression, Female, Lymphocyte Depletion, Macaca mulatta, Quinolines / pharmacology, Simian Acquired Immunodeficiency Syndrome / drug therapy, Simian Acquired Immunodeficiency Syndrome / enzymology, Simian Acquired Immunodeficiency Syndrome / pathology, Simian Immunodeficiency Virus / metabolism

وصف الملف: application/pdf

العلاقة: info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F64064%2F2009/PT; Journal of Clinical Investigation, vol.128(4), p. 1627-1640; https://www.jci.org/articles/view/95127Test; https://hdl.handle.net/10216/127047Test

الإتاحة: https://doi.org/10.1172/JCI95127Test
https://hdl.handle.net/10216/127047Test

المؤلفون: Ferlin, Juliette, Farhat, Rayan, Belouzard, Sandrine, Cocquerel, Laurence, Bertin, Antoine, Hober, Didier, Dubuisson, Jean, Rouillé, Yves

المساهمون: Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Virologie - ULR 3610 (Laboratoire de Virologie), Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), This work was supported in part by the French ‘Agence Nationale de Recherche sur le Sida et les hépatites virales’ (ANRS). J . F. was supported by a pre-doctoral fellowship from ANRS., The authors thank Dr Philippe Desprès, Dr Volker Thiel and Dr Feng Zhang for providing viruses and plasmids. Some data were generated with the help of the imaging core facility of the Institut Pasteur de Lille (BICeL).

المصدر: ISSN: 0022-1317.

مصطلحات موضوعية: coxsackievirus B4, human coronavirus, ADP-ribosylation factor, hepatitis C virus, MESH: Animals, MESH: Brefeldin A, MESH: Gene Knockdown Techniques, MESH: Guanine Nucleotide Exchange Factors/genetics, MESH: Guanine Nucleotide Exchange Factors/metabolism, MESH: Humans, MESH: Mice, MESH: Pyridines/pharmacology, MESH: Quinolines/pharmacology, MESH: RNA Interference, MESH: RNA Viruses/physiology, MESH: Virus Replication/physiology, MESH: Cell Line, MESH: Cell Survival, MESH: Gene Expression Regulation/drug effects, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29923822; hal-02113930; https://hal.science/hal-02113930Test; https://hal.science/hal-02113930/documentTest; https://hal.science/hal-02113930/file/version%20post-print.pdfTest; PUBMED: 29923822

الإتاحة: https://doi.org/10.1099/jgv.0.001099Test
https://hal.science/hal-02113930Test
https://hal.science/hal-02113930/documentTest
https://hal.science/hal-02113930/file/version%20post-print.pdfTest

المساهمون: College of Medicine, Dept. of Pediatrics, Tae-Sun Ha, Ja Ae Nam, Su-Bin Seong, Moin A. Saleem, Se Jin Park, Jae Il Shin, Shin, Jae Il

مصطلحات موضوعية: Acetates/pharmacology, Actinin/metabolism, Adaptor Proteins, Signal Transducing/metabolism, B7-1 Antigen/metabolism, Cells, Cultured, Crk-Associated Substrate Protein/metabolism, Cytoskeletal Proteins/metabolism, Humans, Interleukin-13/pharmacology, Leukotriene Antagonists/pharmacology, Microfilament Proteins/metabolism, Podocytes/drug effects, Podocytes/metabolism, Podocytes/ultrastructure, Quinolines/pharmacology* Zonula Occludens-1 Protein/metabolism, beta Catenin/metabolism, B7-1, Cytoskeletal molecules, Interleukin-13, Leukotriene receptor antagonists, Podocytes, Slit diaphragm

العلاقة: INFLAMMATION RESEARCH; J01059; OAK-2017-05484; https://ir.ymlib.yonsei.ac.kr/handle/22282913/161004Test; https://link.springer.com/article/10.1007%2Fs00011-017-1058-yTest; T201703889; INFLAMMATION RESEARCH, Vol.66(9) : 793-802, 2017

الإتاحة: https://doi.org/10.1007/s00011-017-1058-yTest
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161004Test

المؤلفون: Al-Samkari, Hanny, Galactéros, Frédéric, Glenthøj, Andreas, Rothman, Jennifer A., Andres, Oliver, Grace, Rachael F., Morado-Arias, Marta, Layton, D. Mark, Onodera, Koichi, Verhovsek, Madeleine, Barcellini, Wilma, Chonat, Satheesh, Judge, Malia P., Zagadailov, Erin, Xu, Rengyi, Hawkins, Peter, Beynon, Vanessa, Gheuens, Sarah, van Beers, Eduard J., the ACTIVATE Investigators

المساهمون: Poli Van Creveldkliniek Medisch, Child Health

مصطلحات موضوعية: Adult, Anemia, Hemolytic, Congenital Nonspherocytic/drug therapy, Double-Blind Method, Hemoglobins/analysis, Hemolysis/drug effects, Humans, Piperazines/pharmacology, Pyruvate Kinase/deficiency, Pyruvate Metabolism, Inborn Errors/drug therapy, Quinolines/pharmacology, General Medicine, Randomized Controlled Trial, Multicenter Study, Clinical Trial, Phase III, Journal Article

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/446701Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/446701Test

المؤلفون: Henry Beetham, Billie G.C. Griffith, Olga Murina, Alexander E.P. Loftus, David A. Parry, Carolin Temps, Jayne Culley, Morwenna Muir, Asier Unciti-Broceta, Andrew H. Sims, Adam Byron, Valerie G. Brunton

المصدر: Beetham, H, Griffith, B, Murina, O, Loftus, A, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2021, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research . https://doi.org/10.1158/0008-5472.CAN-21-0373Test
Beetham, H, Griffith, B G C, Murina, O, Loftus, A E P, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2022, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research, vol. 82, no. 4, pp. 632-647 . https://doi.org/10.1158/0008-5472.CAN-21-0373Test

مصطلحات موضوعية: Cancer Research, Breast Neoplasms, Aniline Compounds/pharmacology, Kaplan-Meier Estimate, bosutinib, Protein Serine-Threonine Kinases, Breast Neoplasms/enzymology, Cell Proliferation/drug effects, Gene Knockout Techniques, Breast cancer, Cell Line, Tumor, Signal Transduction/drug effects, Nitriles, Animals, Humans, Integrin-linked kinase, Protein Kinase Inhibitors, Cell Proliferation, Mice, Knockout, Quinolines/pharmacology, Aniline Compounds, Gene Expression Profiling, Xenograft Model Antitumor Assays, synthetic lethality, Gene Expression Regulation, Neoplastic, src-Family Kinases, src-Family Kinases/antagonists & inhibitors, Xenograft Model Antitumor Assays/methods, Oncology, Protein Kinase Inhibitors/pharmacology, Nitriles/pharmacology, Quinolines, MCF-7 Cells, Female, Protein Serine-Threonine Kinases/genetics, Gene Expression Profiling/methods, Signal Transduction, SRC

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60490b72d4b6e9896c2cb3f20e716f6Test
https://www.pure.ed.ac.uk/ws/files/245549967/Loss_of_Integrin_linked_kinase_sensitizes_breast_cancer_to_SRC_inhibitors_published_AAM.pdfTest