المؤلفون: BBJ, BioMe, BioVU, Canadian Partnership for Tomorrow's Health/OHS, China Kadoorie Biobank Collaborative Group, Colorado Center for Personalized Medicine, deCODE Genetics, ESTBB, FinnGen, Generation Scotland, Genes & Health, LifeLines, Mass General Brigham Biobank, Michigan Genomics Initiative, QIMR Berghofer Biobank, Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health Initiative, UKBB, Wang, Ying, Lopera, Esteban, Kerminen, Sini, Karjalainen, Juha, Kurki, Mitja, Partanen, Juulia J., Palta, Priit, Ganna, Andrea, Koskela, Jukka T., Palotie, Aarno V., Daly, Mark J., Neale, Benjamin M., Kaprio, Jaakko

المساهمون: Statistical and population genetics, Complex Disease Genetics, Helsinki Institute of Life Science HiLIFE, Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, Data Science Genetic Epidemiology Lab, Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator

مصطلحات موضوعية: accuracy heterogeneity, Global-Biobank Meta-analysis Initiative, multi-ancestry genetic prediction, polygenic risk scores, 1182 Biochemistry, cell and molecular biology, 1184 Genetics, developmental biology, physiology

وصف الملف: application/pdf

العلاقة: A.R.M. is funded by K99/R00MH117229 . E.L. is funded by the Colciencias fellowship ed.783. S.N. was supported by Takeda Science Foundation . Y.O. was supported by JSPS KAKENHI ( 22H00476 ) and AMED ( JP21gm4010006 , JP22km0405211 , JP22ek0410075 , JP22km0405217 , and JP22ek0109594 ); JST Moonshot R&D ( JPMJMS2021 and JPMJMS2024 ); Takeda Science Foundation; and Bioinformatics Initiative of Osaka University Graduate School of Medicine, Osaka University . E.R.G. is supported by NIH awards R35HG010718 , R01HG011138 , and R01GM140287 and NIH /NIA AG068026 . V.L.F. was supported by the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 675033 (EGRET plus). L.B. and B.B. receive support from the K.G. Jebsen Center for Genetic Epidemiology funded by Stiftelsen Kristian Gerhard Jebsen; the Faculty of Medicine and Health Sciences, NTNU; the Liaison Committee for education, research and innovation in Central Norway; and the Joint Research Committee between St. Olavs Hospital and the Faculty of Medicine and Health Sciences, NTNU. K.L. and R.M. were supported by the Estonian Research Council grant PUT ( PRG687 ) and by INTERVENE. This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement no. 101016775 . W.Z. was supported by the NHGRI of the NIH under award number T32HG010464 . The work of the contributing biobanks was supported by numerous grants from governmental and charitable bodies ( Data S1 ). A.R.M. is funded by K99/R00MH117229. E.L. is funded by the Colciencias fellowship ed.783. S.N. was supported by Takeda Science Foundation. Y.O. was supported by JSPS KAKENHI (22H00476) and AMED (JP21gm4010006, JP22km0405211, JP22ek0410075, JP22km0405217, and JP22ek0109594); JST Moonshot R&D (JPMJMS2021 and JPMJMS2024); Takeda Science Foundation; and Bioinformatics Initiative of Osaka University Graduate School of Medicine, Osaka University. E.R.G. is supported by NIH awards R35HG010718, R01HG011138, and R01GM140287 and NIH/NIA AG068026. V.L.F. was supported by the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 675033 (EGRET plus). L.B. and B.B. receive support from the K.G. Jebsen Center for Genetic Epidemiology funded by Stiftelsen Kristian Gerhard Jebsen; the Faculty of Medicine and Health Sciences, NTNU; the Liaison Committee for education, research and innovation in Central Norway; and the Joint Research Committee between St. Olavs Hospital and the Faculty of Medicine and Health Sciences, NTNU. K.L. and R.M. were supported by the Estonian Research Council grant PUT (PRG687) and by INTERVENE. This project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement no. 101016775. W.Z. was supported by the NHGRI of the NIH under award number T32HG010464. The work of the contributing biobanks was supported by numerous grants from governmental and charitable bodies (Data S1). Study design, A.R.M. J.H. Y.O. and Y.W.; data collection/contribution, L.B. P.A. B.B. P.D. K.H. R.M. Y.M. S.S. J.U. C.W. N.J.C. I.S. and J.H.; data analysis, Y.W. S.N. E.L. S.K. K.T. K.L. M.K. W.Z. K.-H.W. M.-J.F. L.B. V.L.F. and J.H.; writing, Y.W. S.N. E.L. Y.O. A.R.M. and J.H.; revision, Y.W. S.N. E.L. K.T. W.Z. S.S. J.W.S. B.N.W. C.W. E.R.G. N.J.C. Y.O. A.R.M. and J.H. E.R.G. received an honorarium from the journal Circulation Research of the American Heart Association as a member of the editorial board.; BBJ , BioMe , BioVU , Canadian Partnership for Tomorrow's Health/OHS , China Kadoorie Biobank Collaborative Group , Colorado Center for Personalized Medicine , deCODE Genetics , ESTBB , FinnGen , Generation Scotland , Genes & Health , LifeLines , Mass General Brigham Biobank , Michigan Genomics Initiative , QIMR Berghofer Biobank , Taiwan Biobank , The HUNT Study , UCLA ATLAS Community Health Initiative , UKBB , Wang , Y , Lopera , E , Kerminen , S , Karjalainen , J , Kurki , M , Partanen , J J , Palta , P , Ganna , A , Koskela , J T , Palotie , A V , Daly , M J , Neale , B M & Kaprio , J 2023 , ' Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts ' , Cell genomics , vol. 3 , no. 1 , 100241 . https://doi.org/10.1016/j.xgen.2022.100241Test; ORCID: /0000-0002-2527-5874/work/147911502; ORCID: /0000-0002-0154-7222/work/147917209; ORCID: /0000-0001-6361-6759/work/147917210; ORCID: /0000-0001-9320-7008/work/147917252; ORCID: /0000-0002-8147-240X/work/147918311; 85147104921; 1159bdc3-8e2f-40bb-94de-73b5ba0c099a; http://hdl.handle.net/10138/567951Test; 001101897300001

الإتاحة: http://hdl.handle.net/10138/567951Test

المؤلفون: Sarah Finer, Yen-Feng Lin, Michigan Genomics Initiative, Valeria Lo Faro, Benjamin M. Neale, Nathan Ingold, Estonian Biobank, Peter Straub, Jasmina Uzunovic, Triin Laisk, Whitney E. Hornsby, Sebastian Zoellner, Takahiro Konuma, Jordan A. Shavit, Masahiro Kanai, Xue Zhong, Stephen J. Wicks, Taiwan Biobank, Arjun Bhattacharya, Nicholas J. Douville, Yi Ding, BioVU, Jennifer E. Huffman, Christopher R. Gignoux, Kristian Hveem, Serena Sanna, Brooke N. Wolford, Mitja I. Kurki, Aarno Palotie, Yukinori Okada, FinnGen, Clara Lajonchere, Ida Surakka, Mass General Brigham Biobank, Jie Zheng, Caroline Hayward, Riccardo E. Marioni, Chris Griffiths, Lars G. Fritsche, Rasheed Humaira, Ben Michael Brumpton, Kristi Läll, Kuang Lin, Jordan W. Smoller, Lude Franke, Michelle Daya, David C. Whiteman, Karen A. Hunt, Harold Snieder, Jun Lv, Stuart MacGregor, Alicia R. Martin, Juha Karjalainen, Jonathan A. Shortt, Kuan-Han H. Wu, Jibril B Hirbo, Sameer Chavan, Marie-Julie Favé, Snehal Patil, Kristy Crooks, Sarah E. Graham, Tzu-Ting Chen, Michael Preuss, Matthew Zawistowski, Yen-Chen Anne Feng, Iona Y Millwood, Cisca Wijmenga, Cristen J. Willer, Jansonius Nomdo, Kristin Tsuo, Qimr Berghofer Biobank, Koichi Matsuda, LifeLines, Shinichi Namba, Nicholas M. Rafaels, Priit Palta, Unnur Thorsteinsdottir, Chia-Yen Chen, Generation Scotland, Cecilia M. Lindgren, Huiling Zhao, Andrea Ganna, Bogdan Pasaniuc, Maasha Mutaamba, Nancy J. Cox, Zhengming Chen, George Davey Smith, Mark J. Daly, Sarah E. Medland, Yu Guo, Daniel H. Geschwind, Matthew Law, Judith M. Vonk, Eimear E. Kenny, David J. Porteous, Tian Ge, Judy H. Cho, UK Biobank, Ruth J. F. Loos, Eric R. Gamazon, Wei Zhou, Richard C. Trembath, Philip Awadalla, Kathleen C. Barnes, David A. van Heel, Kari Stefansson, Archie Campbell, Hilary C. Martin, Tom R. Gaunt, Ruth E. Johnson, Sinéad B. Chapman, Esteban A Lopera-Maya, Michael Boehnke, Brett Vanderwerff, Catherine M. Olsen, Marike Boezen, Anita Pandit, BioMe, Ran Tao, Hilary K. Finucane, Anne Richmond, Ying Wang, Liming Li, Geertruida H. de Bock, John Wright, Xiang Zhou, Robin G. Walters, Reedik Mägi, Hailiang Huang

مصطلحات موضوعية: Disease gene, 0303 health sciences, South asia, Collaborative network, Genome-wide association study, Computational biology, Biology, Biobank, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Baseline characteristics, Meta-analysis, 030217 neurology & neurosurgery, 030304 developmental biology, Genetic association

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9439cf051f4d6442c096778e0c35b0c4Test
https://doi.org/10.1101/2021.11.19.21266436Test