Association between use of Qingfei Paidu Tang and mortality in hospitalized patients with COVID-19: A national retrospective registry study
| العنوان: | Association between use of Qingfei Paidu Tang and mortality in hospitalized patients with COVID-19: A national retrospective registry study |
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| المؤلفون: | Haibo Zhang, Bowang Chen, Lanxia Gan, Zhiye Zhou, Jiapeng Lu, Haibo Wang, Xueke Bai, Xi Li, Ying Shi, Shuang Hu, Qing Wang, Lihua Zhang, Jiamin Liu, Xiaoyan Zhang, Xin Zheng, Jing Li |
| المصدر: | Phytomedicine |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Qingfei Paidu Tang, Pharmaceutical Science, 0302 clinical medicine, Interquartile range, Drug Discovery, Medicine, Hospital Mortality, Registries, Medicine, Chinese Traditional, QPT, Qingfei Paidu Tang, 0303 health sciences, Incidence, Incidence (epidemiology), Medical record, Hazard ratio, OR, odds ratios, HR, hazard ratios, Acute Kidney Injury, Middle Aged, IPTW, inverse probability treatment weighting, SMD, standard mean difference, COVID-19, Coronavirus Disease 2019, 030220 oncology & carcinogenesis, Molecular Medicine, Female, Original Article, Chemical and Drug Induced Liver Injury, Adult, China, medicine.medical_specialty, Lower risk, 03 medical and health sciences, Internal medicine, Humans, Mortality, IQR, interquartile range, Aged, Proportional Hazards Models, Retrospective Studies, 030304 developmental biology, Pharmacology, business.industry, Proportional hazards model, COVID-19, Retrospective cohort study, Odds ratio, Confidence interval, COVID-19 Drug Treatment, CI, confidence interval, Complementary and alternative medicine, Propensity score matching, business, Drugs, Chinese Herbal |
| الوصف: | Background : Qingfei Paidu Tang (QPT), a formula of traditional Chinese medicine, which was suggested to be able to ease symptoms in patients with Coronavirus Disease 2019 (COVID-19), has been recommended by clinical guidelines and widely used to treat COVID-19 in China. However, whether it decreases mortality remains unknown. Purpose : We aimed to explore the association between QPT use and in-hospital mortality among patients hospitalized for COVID-19. Study design : A retrospective study based on a real-world database was conducted. Methods : We identified patients consecutively hospitalized with COVID-19 in 15 hospitals from a national retrospective registry in China, from January through May 2020. Data on patients’ characteristics, treatments, and outcomes were extracted from the electronic medical records. The association of QPT use with COVID-19 related mortality was evaluated using Cox proportional hazards models based on propensity score analysis. Results : Of the 8939 patients included, 28.7% received QPT. The COVID-19 related mortality was 1.2% (95% confidence interval [CI] 0.8% to 1.7%) among the patients receiving QPT and 4.8% (95% CI 4.3% to 5.3%) among those not receiving QPT. After adjustment for patient characteristics and concomitant treatments, QPT use was associated with a relative reduction of 50% in in-hospital COVID-19 related mortality (hazard ratio, 0.50; 95% CI, 0.37 to 0.66 P Graphical abstract Image, graphical abstract |
| تدمد: | 0944-7113 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc91bde7b94928332a0a85d8d5cf1399Test https://doi.org/10.1016/j.phymed.2021.153531Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dc91bde7b94928332a0a85d8d5cf1399 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09447113 |
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