دورية أكاديمية
Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies.
| العنوان: | Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies. |
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| المؤلفون: | Bowman, R.L., Klemm, F., Akkari, L., Pyonteck, S.M., Sevenich, L., Quail, D.F., Dhara, S., Simpson, K., Gardner, E.E., Iacobuzio-Donahue, C.A., Brennan, C.W., Tabar, V., Gutin, P.H., Joyce, J.A. |
| المصدر: | Cell reports, vol. 17, no. 9, pp. 2445-2459 |
| سنة النشر: | 2016 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Animals, Base Sequence, Bone Marrow Cells/pathology, Brain Neoplasms/genetics, Brain Neoplasms/pathology, Cell Lineage, Disease Models, Animal, Gene Expression Regulation, Neoplastic, Gene Regulatory Networks, Glioma/genetics, Glioma/pathology, Humans, Integrin alpha4/metabolism, Macrophage Activation, Macrophages/metabolism, Macrophages/pathology, Mice, Microglia/metabolism, Microglia/pathology, Sequence Analysis, RNA, Transcription Factors/metabolism, CD49D, Macrophage, brain metastasis, glioma, microglia, tumor-associated macrophages |
| الوصف: | Extensive transcriptional and ontogenetic diversity exists among normal tissue-resident macrophages, with unique transcriptional profiles endowing the cells with tissue-specific functions. However, it is unknown whether the origins of different macrophage populations affect their roles in malignancy. Given potential artifacts associated with irradiation-based lineage tracing, it remains unclear if bone-marrow-derived macrophages (BMDMs) are present in tumors of the brain, a tissue with no homeostatic involvement of BMDMs. Here, we employed multiple models of murine brain malignancy and genetic lineage tracing to demonstrate that BMDMs are abundant in primary and metastatic brain tumors. Our data indicate that distinct transcriptional networks in brain-resident microglia and recruited BMDMs are associated with tumor-mediated education yet are also influenced by chromatin landscapes established before tumor initiation. Furthermore, we demonstrate that microglia specifically repress Itga4 (CD49D), enabling its utility as a discriminatory marker between microglia and BMDMs in primary and metastatic disease in mouse and human. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27840052; info:eu-repo/semantics/altIdentifier/eissn/2211-1247; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_D0474EC65CDA8; https://serval.unil.ch/notice/serval:BIB_D0474EC65CDATest; https://serval.unil.ch/resource/serval:BIB_D0474EC65CDA.P003/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_D0474EC65CDA8Test |
| DOI: | 10.1016/j.celrep.2016.10.052 |
| الإتاحة: | https://doi.org/10.1016/j.celrep.2016.10.052Test https://serval.unil.ch/notice/serval:BIB_D0474EC65CDATest https://serval.unil.ch/resource/serval:BIB_D0474EC65CDA.P003/REF.pdfTest http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_D0474EC65CDA8Test |
| حقوق: | info:eu-repo/semantics/openAccess ; Copying allowed only for non-profit organizations ; https://serval.unil.ch/disclaimerTest |
| رقم الانضمام: | edsbas.21386A48 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.celrep.2016.10.052 |
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