التفاصيل البيبلوغرافية
| العنوان: |
OP0160 HLA-DRB1 ASSOCIATIONS WITH AUTOANTIBODY-DEFINED SUBGROUPS IN IDIOPATHIC INFLAMMATORY MYOPATHIES (IIM) |
| المؤلفون: |
Leclair, V., Galindo-Feria, A. S., Rothwell, S., Kryštůfková, O., Mann, H., Pyndt Diederichsen, L., Andersson, H., Klein, M., Tansley, S., Mchugh, N., Lamb, J., Vencovský, J., Chinoy, H., Holmqvist, M., Padyukov, L., Lundberg, I. E., Diaz-Gallo, L. M. |
| المصدر: |
Annals of the Rheumatic Diseases ; volume 81, issue Suppl 1, page 104.1-105 ; ISSN 0003-4967 1468-2060 |
| بيانات النشر: |
BMJ |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
General Biochemistry, Genetics and Molecular Biology, Immunology, Immunology and Allergy, Rheumatology |
| الوصف: |
Background There is a gap between how IIM patients are classified in practice and current validated classification criteria 1 . Also, different associations with genetic variations in HLA can inform about different T-cell mechanisms involved in disease pathogenesis. Objectives We aimed to systematically study associations between HLA-DRB1 alleles, clinical manifestations, and autoantibody-defined IIM subgroups. Methods We included 1348 IIM patients from five European countries. An unsupervised cluster analysis was performed using 14 autoantibodies: anti-Jo1, -PL7, -PL12, -EJ, -OJ, -SRP, -U1RNP, -Ro52, -Mi2, -TIF1γ, -MDA5, -PMScl, -SAE1, and -NXP2 to identify patients’ subgroups. Logistic regressions were used to estimate the associations between HLA-DRB1 alleles, clinical manifestations and the identified subgroups. Results Eight subgroups were defined by the autoantibody status (Table 1). Three of the subgroups (1, 2 and 6) have overlapping autoantibodies, while four are almost monospecific (3,4,5 and 7), and one (8) has patients negative for tested autoantibodies. Figure 1 represents the significant associations between HLA-DRB1 alleles and the eight subgroups. Heliotrope rash and Gottron’s sign were significantly more frequent in subgroups 3 (OR:2.2 95%CI:[1.1-4.8], OR:2.6 95%CI:[1.3-5.9], respectively), 4 (OR:12 95%CI:[3.6-75], OR:7.8 95%CI:[2.8-33], respectively) and 7 (OR:22 95%CI:[4.5-385], OR:10 95%CI:[3.1-65], respectively), and Raynaud’s phenomenon was significantly more frequent in subgroup 6 (OR:3.3 95%CI:[1.2-11]). Table 1. Autoantibody-defined subgroups using an unsupervised cluster analysis. Subgroups/ Medoids Variables 1 Ro52 2 U1RNP 3 PMScl 4 Mi2 5 Jo1 6 Jo1/Ro52 7 TIF1 8 None* All n (% ) 137 (10) 183 (14) 107 (8) 65 (5) 119 (9) 140 (10) 78 (6) 519 (39) 1348 (100) Female (% ) 93 (68) 116 (63) 79 (74) 45 (69) 76 (64) 96 (69) 64 (82) 313 (60) 882 (65) Age at diagnosis, median (IQR) 56 (16) 51.5 (23) 51 (25) 57 (22.5) 47.5 (23.25) 52 (19.5) 53.5 (21.75) 58 (22) 55 (23) Autoantibodies Anti-Jo1 0 6 ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1136/annrheumdis-2022-eular.1695 |
| الإتاحة: |
https://doi.org/10.1136/annrheumdis-2022-eular.1695Test |
| رقم الانضمام: |
edsbas.DEEF5ED2 |
| قاعدة البيانات: |
BASE |
