دورية أكاديمية
Usefulness of impulse oscillometry and fractional exhaled nitric oxide in children with Eosinophilic bronchitis
| العنوان: | Usefulness of impulse oscillometry and fractional exhaled nitric oxide in children with Eosinophilic bronchitis |
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| المساهمون: | Yoon Hee Kim, Kyung Won Kim, Jiyoung Baek, Hyun Bin Park, Hyemi Kim, Kyung-Joo Song, Jae Myun Lee, Myung Hyun Sohn, Kyu-Earn Kim, Kim, Kyung Won, Kim, Kyu Earn, Kim, Yoon Hee, Park, Hyun Bin, Son, Myung Hyun, Lee, Jae Myun |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Asthma/diagnosis, Asthma/metabolism, Asthma/physiopathology, Biomarkers/metabolism, Bronchial Provocation Tests, Bronchitis/diagnosis, Bronchitis/metabolism, Bronchitis/physiopathology, Bronchoconstrictor Agents, Bronchodilator Agents, Case-Control Studies, Child, Diagnosis, Differential, Eosinophils/metabolism, Exhalation, Female, Humans, Leukocyte Count, Male, Methacholine Chloride, Nitric Oxide/metabolism, Oscillometry, Pulmonary Eosinophilia/diagnosis, Pulmonary Eosinophilia/metabolism, Pulmonary Eosinophilia/physiopathology, ROC Curve, Sensitivity and Specificity, Spirometry, Sputum/metabolism |
| الوصف: | BACKGROUND: Eosinophilic bronchitis (EB) is a common cause of chronic cough. Although EB shares many immunopathologic features with asthma, it does not show airway hyperresponsiveness or reversible airway obstruction by spirometry. OBJECTIVE: Compared to healthy children without pulmonary disease, we hypothesized that EB patients would demonstrate abnormal pulmonary function and inflammation with impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO), which are more sensitive tests of these parameters than spirometry. METHODS: A total of 232 children with asthma, 109 with EB, and 115 control subjects were enrolled. We compared pulmonary function parameters and FeNO levels among the three groups. Additionally, we designated a screening cutoff value of FeNO combined with IOS parameters to distinguish EB from the control group, and identify which children with EB have more asthmatic characteristics. RESULTS: By IOS, the bronchodilator response of the EB and asthma groups increased significantly compared to controls for both reactance at 5�덳z (�� X5) and reactance area (�� AX) (P��<��0.0001). Cutoff values to distinguish EB from controls were a �� X5 of -20% (sensitivity, 77.5%; specificity, 49.6%), and �� AX of -30% (sensitivity, 75.0%; specificity, 46.0%), when the FeNO is 20�뎟pb. CONCLUSIONS: Reversible airway obstruction in IOS and elevated FeNO levels can be detected in children with EB. This would support that EB in children shows airway characteristics similar to those of asthma, and that a continuum exists between asthma and EB. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 8755-6863 1099-0496 |
| العلاقة: | PEDIATRIC PULMONOLOGY; J02491; OAK-2013-01113; https://ir.ymlib.yonsei.ac.kr/handle/22282913/87230Test; T201302260; PEDIATRIC PULMONOLOGY, Vol.48(3) : 221-228, 2013 |
| DOI: | 10.1002/ppul.22631 |
| DOI: | 10.1002/ppul.22631/abstract |
| الإتاحة: | https://doi.org/10.1002/ppul.22631Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/87230Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ ; not free |
| رقم الانضمام: | edsbas.4087ECAE |
| قاعدة البيانات: | BASE |
| تدمد: | 87556863 10990496 |
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| DOI: | 10.1002/ppul.22631 |