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1دورية أكاديمية
المؤلفون: Prema S. Karunanithi, Puja Dhanota, J. Bennett Addison, Shen Tong, Oliver Fiehn, Philipp Zerbe
المصدر: BMC Plant Biology, Vol 19, Iss 1, Pp 1-14 (2019)
مصطلحات موضوعية: Diterpene synthase, Cytochrome P450 monooxygenase, Diterpenoid biosynthesis, Marrubiin, Plant natural products, Marrubium vulgare, Botany, QK1-989
وصف الملف: electronic resource
العلاقة: http://link.springer.com/article/10.1186/s12870-019-1702-5Test; https://doaj.org/toc/1471-2229Test
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2دورية أكاديمية
المؤلفون: Guillaume Mata (1685596), Dillon H. Miles (8962160), Samuel L. Drew (8682102), Jeremy Fournier (3594275), Kenneth V. Lawson (2391673), Artur K. Mailyan (1588903), Ehesan U. Sharif (6847676), Xuelei Yan (1698157), Joel W. Beatty (1328199), Jesus Banuelos (4036886), Jie Chen (5892), Elaine Ginn (2124058), Ada Chen (1698127), Kimberline Y. Gerrick (6061382), Amber T. Pham (8682105), Kent Wong (2160739), Divyank Soni (9383865), Puja Dhanota (6506090), Stefan G. Shaqfeh (9383868), Cesar Meleza (6899225), Nell Narasappa (11592941), Hema Singh (11592944), Xiaoning Zhao (184301), Lixia Jin (1570120), Ulrike Schindler (9383871), Matthew J. Walters (296691), Stephen W. Young (7022015), Nigel P. Walker (8682108), Manmohan Reddy Leleti (8682111), Jay P. Powers (1721107), Jenna L. Jeffrey (2029015)
مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Immunology, Developmental Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, early lead series, tumor immune microenvironment, significant immune response, molecular docking studies, selective pi3kγ inhibitors, pyrazolopyrimidine amide inhibitors, 56 , immune cells, vitro <, studies indicate, pyrazolopyrimidine isoindolinones, optimal amide, metabolic stability, m1 macrophages, like properties, kinase γ, isoindolinone substituents, inflammatory phenotype, inflammatory mediators, increasing pro, highly potent, highly expressed, favorable drug
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المؤلفون: Dillon H. Miles, Ada Chen, Manmohan Reddy Leleti, Divyank Soni, Stephen W Young, Artur K. Mailyan, Kenneth V. Lawson, Stefan G Shaqfeh, Ehesan U. Sharif, Jenna L. Jeffrey, Jesus Banuelos, Xuelei Yan, Samuel L Drew, Kimberline Gerrick, Nigel Walker, Puja Dhanota, Lixia Jin, Jay P. Powers, Elaine Ginn, Guillaume Mata, Kent Wong, Hema Singh, Jeremy Fournier, Joel W. Beatty, Ulrike Schindler, Amber Pham, Matthew J. Walters, Jie Chen, Cesar Meleza, Xiaoning Zhao, Nell Narasappa
المصدر: Journal of Medicinal Chemistry. 65:1418-1444
مصطلحات موضوعية: Male, Pyrazolopyrimidine, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Immune system, Amide, Drug Discovery, Animals, Class Ib Phosphatidylinositol 3-Kinase, Humans, Structure–activity relationship, Potency, Phosphoinositide-3 Kinase Inhibitors, Phosphoinositide 3-kinase, biology, Amides, Phenotype, In vitro, Rats, Molecular Docking Simulation, Pyrimidines, chemistry, Biochemistry, Drug Design, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37aec4464f4375ff8b99d31a40b9e89Test
https://doi.org/10.1021/acs.jmedchem.1c01153Test -
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المؤلفون: Dillon H. Miles, Ada Chen, Manmohan Reddy Leleti, Divyank Soni, Stephen W Young, Artur K. Mailyan, Kenneth V. Lawson, Stefan G Shaqfeh, Ehesan U. Sharif, Pei-Yu Chen, Jenna L. Jeffrey, Jesus Banuelos, Xuelei Yan, Samuel L Drew, Nigel Walker, Puja Dhanota, Lixia Jin, Jay P. Powers, Elaine Ginn, Guillaume Mata, Kent Wong, Jeremy Fournier, Joel W. Beatty, Rhiannon Thomas-Tran, Ulrike Schindler, Amber Pham, Matthew J. Walters, Jie Chen, Cesar Meleza, Xiaoning Zhao
المصدر: Journal of Medicinal Chemistry. 63:11235-11257
مصطلحات موضوعية: Gene isoform, Stereochemistry, Crystallography, X-Ray, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Animals, Class Ib Phosphatidylinositol 3-Kinase, Humans, Binding site, Phosphoinositide-3 Kinase Inhibitors, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Trifluoromethyl, Bicyclic molecule, Lipid signaling, Rats, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, Drug Design, Molecular Medicine, Selectivity, Adenosine triphosphate
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237c477c3969b94ce636dfc76aca3e4fTest
https://doi.org/10.1021/acs.jmedchem.0c01203Test -
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المؤلفون: J. Bennett Addison, Oliver Fiehn, Shen Tong, Philipp Zerbe, Puja Dhanota, Prema Sambandaswami Karunanithi
المصدر: BMC Plant Biology, Vol 19, Iss 1, Pp 1-14 (2019)
BMC Plant Biology
BMC plant biology, vol 19, iss 1مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, Marrubium vulgare, Plant Biology, Plant Science, Marrubiin, Medicinal, 01 natural sciences, Substrate Specificity, Hydroxylation, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Diterpene synthase, Gene Expression Regulation, Plant, Diterpenoid biosynthesis, lcsh:Botany, Plant Proteins, 2. Zero hunger, biology, Cytochrome P450 monooxygenase, food and beverages, Plants, Plants, Genetically Modified, lcsh:QK1-989, Biochemistry, Diterpenes, Biotechnology, Marrubium, Research Article, Crop and Pasture Production, Plant Biology & Botany, Genetically Modified, Plant natural products, Flowers, Saccharomyces cerevisiae, Microbiology, Gas Chromatography-Mass Spectrometry, Metabolic engineering, 03 medical and health sciences, Isomerism, Biosynthesis, Tobacco, Genetics, Plants, Medicinal, Gene Expression Profiling, Cytochrome P450, Plant, Monooxygenase, biology.organism_classification, Terpenoid, Plant Leaves, 030104 developmental biology, Gene Expression Regulation, chemistry, biology.protein, Diterpene, 010606 plant biology & botany
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fcb1bfd5d193ee941c02619f1a064e9Test
https://doi.org/10.1186/s12870-019-1702-5Test -
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النص الكامل