دورية أكاديمية
Association between macrocalcification and papillary thyroid carcinoma and corresponding valuable diagnostic tool: retrospective study
| العنوان: | Association between macrocalcification and papillary thyroid carcinoma and corresponding valuable diagnostic tool: retrospective study |
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| المؤلفون: | Mengyao Ye, Shan Wu, Qi Zhou, Fang Wang, Xiaojun Chen, Xiaohua Gong, Wenjun Wu |
| المصدر: | World Journal of Surgical Oncology, Vol 21, Iss 1, Pp 1-7 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Surgery LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Thyroid nodule, Papillary thyroid carcinoma, Macrocalcification, Fine needle aspiration biopsy, Proto-Oncogene Proteins B-raf V600E, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Background Microcalcifications are suggested to be an indicator of thyroid malignancy, especially for papillary thyroid carcinoma (PTC), nonetheless, the association between macrocalcification and PTC is underexplored. Furthermore, screening methods like ultrasonography and ultrasound-guided fine needle aspiration biopsy (US-FNAB) are limited in evaluating macro-calcified thyroid nodules. Thus, we aimed to investigate the relationship between macrocalcification and PTC. We also explored the diagnostic efficiency of US-FNAB and proto-Oncogene Proteins B-raf V600E (BRAF V600E) mutation in macro-calcified thyroid nodules evaluation. Methods A retrospective research of 2645 thyroid nodules from 2078 participants was performed and divided into three groups as non-, micro-, and macro-calcified for further PTC incidence comparison. Besides, a total of 100 macro-calcified thyroid nodules with both results of US-FNAB and BRAF V600E mutation were screened out for subsequent evaluation of diagnostic efficiency. Results Compared to non-calcification, macrocalcification showed a significantly higher incidence of PTC (31.5% vs. 23.2%, P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1477-7819 |
| العلاقة: | https://doaj.org/toc/1477-7819Test |
| DOI: | 10.1186/s12957-023-03016-7 |
| الوصول الحر: | https://doaj.org/article/df8c4965bc6e49cebb777a2441738517Test |
| رقم الانضمام: | edsdoj.f8c4965bc6e49cebb777a2441738517 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14777819 |
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| DOI: | 10.1186/s12957-023-03016-7 |