المؤلفون: McMillan, David, Martinez-Fleites, Carlos, Porter, John, Fox, David, Davis, Rachel E., Mori, Prashant, Ceska, Tom, Carrington, Bruce, Lawson, Alastair, Bourne, Tim, O'Connell, James

المصدر: Faculty Publications

مصطلحات موضوعية: molecules, TNF-TNFR1, TNF, Tumour necrosis factor, tumor, Algorithms, Animals, Binding, Competitive (drug effects), Humans, Models, Molecular, Protein Binding (drug effects), Protein Conformation (drug effects), Protein Multimerization (drug effects), Receptors, Tumor Necrosis Factor, Type I (chemistry, metabolism), Signal Transduction (drug effects), Small Molecule Libraries (chemistry, pharmacology), Tumor Necrosis Factor-alpha (chemistry, Public Health Education and Promotion

وصف الملف: application/pdf

العلاقة: https://scholarcommons.sc.edu/sph_health_promotion_education_behavior_facpub/373Test; https://scholarcommons.sc.edu/context/sph_health_promotion_education_behavior_facpub/article/1374/viewcontent/s41467_020_20828_3.pdfTest

الإتاحة: https://doi.org/10.1038/s41467-020-20828-3Test;
https://doi.org/10.1038/s41467-020-20828-3Test
https://scholarcommons.sc.edu/sph_health_promotion_education_behavior_facpub/373Test
https://scholarcommons.sc.edu/context/sph_health_promotion_education_behavior_facpub/article/1374/viewcontent/s41467_020_20828_3.pdfTest

المؤلفون: O'Connell, James, Porter, John, Kroeplien, Boris, Norman, Tim, Rapecki, Stephen, Davis, Rachel E., McMillan, David, Arakaki, Tracy, Burgin, Alex, Fox Iii, David, Ceska, Tom, Lecomte, Fabien, Maloney, Alison, Vugler, Alex, Carrington, Bruce, Cossins, Benjamin P, Bourne, Tim, Lawson, Alastair

المصدر: Faculty Publications

مصطلحات موضوعية: Drug discovery and development, Screening, Structure-based drug design, Tumour necrosis factor, Animals, Anti-Inflammatory Agents (pharmacology, therapeutic use), Arthritis, Experimental (drug therapy, immunology), Cell Line, Crystallography, X-Ray, Drug Discovery, Male, Mice, Molecular Dynamics Simulation, Neutrophil Infiltration (drug effects), Neutrophils (drug effects, Protein Multimerization (drug effects), Protein Stability (drug effects), Protein Structure, Quaternary (drug effects), Receptors, Tumor Necrosis Factor, Type I (immunology, metabolism), Recombinant Proteins (isolation & purification, metabolism, ultrastructure)

وصف الملف: application/pdf

العلاقة: https://scholarcommons.sc.edu/sph_health_promotion_education_behavior_facpub/376Test; https://scholarcommons.sc.edu/context/sph_health_promotion_education_behavior_facpub/article/1377/viewcontent/s41467_019_13616_1.pdfTest

الإتاحة: https://doi.org/10.1038/s41467-019-13616-1Test;
https://doi.org/10.1038/s41467-019-13616-1Test
https://scholarcommons.sc.edu/sph_health_promotion_education_behavior_facpub/376Test
https://scholarcommons.sc.edu/context/sph_health_promotion_education_behavior_facpub/article/1377/viewcontent/s41467_019_13616_1.pdfTest

المؤلفون: Dang, Dung T., van Onzen, Arthur H.A.M., Dorland, Yvonne L., Brunsveld, Luc

المصدر: Dang , D T , van Onzen , A H A M , Dorland , Y L & Brunsveld , L 2018 , ' Cucurbit[8]uril reactivation of an inactivated caspase-8 mutant reveals differentiated enzymatic substrate processing ' , ChemBioChem , vol. 19 , no. 23 , pp. 2490-2494 . https://doi.org/10.1002/cbic.201800521Test

مصطلحات موضوعية: caspases, cucurbit[8]uril, protein assembly, protein engineering, supramolecular chemistry, Enzyme Reactivators/chemistry, Catalysis/drug effects, Imidazoles/chemistry, Protein Multimerization/drug effects, Humans, Bridged-Ring Compounds/chemistry, Point Mutation, Caspase 8/genetics

وصف الملف: application/pdf

العلاقة: https://research.tue.nl/en/publications/414d47ec-dd89-46a6-aa55-5b17a226aec3Test

الإتاحة: https://doi.org/10.1002/cbic.201800521Test
https://research.tue.nl/en/publications/414d47ec-dd89-46a6-aa55-5b17a226aec3Test
https://pure.tue.nl/ws/files/115773477/Dang_et_al_2018_ChemBioChem.pdfTest
http://www.scopus.com/inward/record.url?scp=85056096357&partnerID=8YFLogxKTest

المؤلفون: Gabrielsen, Mads, Buetow, Lori, Nakasone, Mark A, Ahmed, Syed Feroj, Sibbet, Gary J, Smith, Brian O, Zhang, Wei, Sidhu, Sachdev S, Huang, Danny T

المصدر: Gabrielsen , M , Buetow , L , Nakasone , M A , Ahmed , S F , Sibbet , G J , Smith , B O , Zhang , W , Sidhu , S S & Huang , D T 2017 , ' A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants ' , Molecular Cell , vol. 68 , no. 2 , pp. 456-470.e10 . https://doi.org/10.1016/j.molcel.2017.09.027Test

مصطلحات موضوعية: Drug Discovery/methods, Enzyme Activators/chemistry, Enzyme Inhibitors/chemistry, HEK293 Cells, HeLa Cells, Humans, Protein Multimerization/drug effects, Tumor Suppressor Proteins/agonists, Ubiquitin-Protein Ligase Complexes/antagonists & inhibitors, Ubiquitin-Protein Ligases, X-Linked Inhibitor of Apoptosis Protein/agonists

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/b2fb8a6a-4fe5-46d1-aaf5-7b50d4f5e663Test

الإتاحة: https://doi.org/10.1016/j.molcel.2017.09.027Test
https://discovery.dundee.ac.uk/en/publications/b2fb8a6a-4fe5-46d1-aaf5-7b50d4f5e663Test
https://discovery.dundee.ac.uk/ws/files/75155004/PIIS1097276517307050.pdfTest

المؤلفون: Royal, Alice A, Tinker, Andrew, Harmer, Stephen C

المصدر: Royal , A A , Tinker , A & Harmer , S C 2017 , ' Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking ' , PLoS ONE , vol. 12 , no. 10 , e0186293 . https://doi.org/10.1371/journal.pone.0186293Test

مصطلحات موضوعية: Animals, CHO Cells, Cell Membrane/drug effects, Cricetinae, Cricetulus, Endoplasmic Reticulum/drug effects, Genes, Reporter, Golgi Apparatus/drug effects, HEK293 Cells, Humans, Ion Channel Gating/drug effects, KCNQ1 Potassium Channel/metabolism, Mutation/genetics, Phosphatidylinositol 4,5-Diphosphate/metabolism, Potassium Channels, Voltage-Gated/metabolism, Protein Binding/drug effects, Protein Multimerization/drug effects, Protein Transport/drug effects, Sirolimus/pharmacology

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1371/journal.pone.0186293Test
https://hdl.handle.net/1983/e514aac4-3f9f-4fe8-bf0c-8fe083982c1bTest
https://research-information.bris.ac.uk/en/publications/e514aac4-3f9f-4fe8-bf0c-8fe083982c1bTest
https://research-information.bris.ac.uk/ws/files/184566443/Royal_2017_PLoSOne_Phosphatidylinositol_4_5_bisphosphate_is_required_for_KCNQ1_KCNE1_channel_function_but_not_anterograde_trafficking.pdfTest

المؤلفون: Perni, Michele, Galvagnion, Céline, Maltsev, Alexander, Meisl, Georg, Müller, Martin B D, Challa, Pavan K, Kirkegaard, Julius B, Flagmeier, Patrick, Cohen, Samuel I A, Cascella, Roberta, Chen, Serene W, Limbocker, Ryan, Sormanni, Pietro, Heller, Gabriella T, Aprile, Francesco A, Cremades, Nunilo, Cecchi, Cristina, Chiti, Fabrizio, Nollen, Ellen A A, Knowles, Tuomas P J, Vendruscolo, Michele, Bax, Adriaan, Zasloff, Michael, Dobson, Christopher M

المصدر: Perni , M , Galvagnion , C , Maltsev , A , Meisl , G , Müller , M B D , Challa , P K , Kirkegaard , J B , Flagmeier , P , Cohen , S I A , Cascella , R , Chen , S W , Limbocker , R , Sormanni , P , Heller , G T , Aprile , F A , Cremades , N , Cecchi , C , Chiti , F , Nollen , E A A , Knowles , T P J , Vendruscolo , M , Bax , ....

مصطلحات موضوعية: Algorithms, Amino Acid Sequence, Animals, Genetically Modified, Biological Products/chemistry, Caenorhabditis elegans/genetics, Cell Line, Tumor, Cholestanols/chemistry, Humans, Membrane Lipids/chemistry, Molecular Structure, Neuroblastoma/metabolism, Paresis/genetics, Parkinson Disease/metabolism, Protein Aggregates/drug effects, Protein Aggregation, Pathological/prevention & control, Protein Binding/drug effects, Protein Multimerization/drug effects, alpha-Synuclein/chemistry

الإتاحة: https://doi.org/10.1073/pnas.1610586114Test
https://curis.ku.dk/portal/da/publications/a-natural-product-inhibits-the-initiation-of-synuclein-aggregation-and-suppresses-its-toxicityTest(66f5d50b-c4dc-4871-aa17-b0b795c35b1e).html

المؤلفون: Guzmán-Hernández, Maria Luisa, Potter, Gael, Egervari, Kristof Levente, Kiss, Jozsef Zoltan, Balla, Tamas

المصدر: ISSN: 1059-1524 ; Molecular biology of the cell, vol. 25, no. 7 (2014) p. 1061-1072.

مصطلحات موضوعية: info:eu-repo/classification/ddc/616.8, Animals, COS Cells, Cell Membrane/drug effects/metabolism/ultrastructure, Cercopithecus aethiops, Endoplasmic Reticulum/drug effects/metabolism, GTP Phosphohydrolases/metabolism, Glycosylation/drug effects, Golgi Apparatus/drug effects/metabolism, Green Fluorescent Proteins/metabolism, Human Umbilical Vein Endothelial Cells/drug effects/metabolism, Humans, Phosphatidylinositol 4,5-Diphosphate/metabolism, Protein Multimerization/drug effects, Protein Transport/drug effects, Recombinant Fusion Proteins/metabolism, Sirolimus/pharmacology, Vascular Endothelial Growth Factor A/secretion/ultrastructure

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/24501421; https://archive-ouverte.unige.ch/unige:74474Test; unige:74474

الإتاحة: https://doi.org/10.1091/mbc.E13-07-0418Test
https://archive-ouverte.unige.ch/unige:74474Test

المؤلفون: Arthur H. A. M. van Onzen, Yvonne L. Dorland, Luc Brunsveld, Dung Thanh Dang

المساهمون: Chemical Biology, Biomedical Engineering

المصدر: ChemBioChem, 19(23), 2490-2494. Wiley-VCH Verlag
Chembiochem

مصطلحات موضوعية: Bridged-Ring Compounds, Stereochemistry, Caspase 8/genetics, Dimer, Mutant, Supramolecular chemistry, protein assembly, 010402 general chemistry, 01 natural sciences, Biochemistry, Catalysis, supramolecular chemistry, Catalysis/drug effects, chemistry.chemical_compound, Enzyme Reactivators, Enzyme Reactivators/chemistry, Imidazoles/chemistry, Humans, Point Mutation, Bridged-Ring Compounds/chemistry, Protein Dimerization, Molecular Biology, Caspase 8, Full Paper, biology, 010405 organic chemistry, Organic Chemistry, Imidazoles, Substrate (chemistry), Active site, protein engineering, Protein engineering, Full Papers, Protein Multimerization/drug effects, 0104 chemical sciences, Monomer, caspases, chemistry, cucurbit[8]uril, biology.protein, Molecular Medicine, Protein Multimerization

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0fdb701117397593ac304bbfd4cf9afTest
https://doi.org/10.1002/cbic.201800521Test

المؤلفون: Arribat, Yoan, Bonneaud, Nathalie, Talmat-Amar, Yasmina, Layalle, Sophie, Parmentier, Marie-Laure, Maschat, Florence

المساهمون: Institut de Génomique Fonctionnelle (IGF), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 1932-6203.

مصطلحات موضوعية: Amino Acid Sequence, Animals, Disease Models, Animal, Drosophila melanogaster/*drug effects/genetics/growth & development/metabolism, Eye/drug effects/metabolism/pathology, Female, Gene Expression Regulation, HeLa Cells, Humans, Huntington Disease/genetics/*metabolism/pathology, Larva/*drug effects/genetics/growth & development/metabolism, Male, Molecular Sequence Data, Motor Activity, Mutation, Nerve Tissue Proteins/*chemistry/genetics/metabolism, Neurons/drug effects/metabolism/pathology, Oligopeptides/chemistry/isolation & purification/*pharmacology, Peptides/*chemistry/metabolism, Protein Binding, Protein Multimerization/drug effects, Protein Transport, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

العلاقة: hal-01984749; https://hal.science/hal-01984749Test; https://hal.science/hal-01984749/documentTest; https://hal.science/hal-01984749/file/pone.0068775.pdfTest

الإتاحة: https://doi.org/10.1371/journal.pone.0068775Test
https://hal.science/hal-01984749Test
https://hal.science/hal-01984749/documentTest
https://hal.science/hal-01984749/file/pone.0068775.pdfTest

المؤلفون: Shen, Weiwei, Frieden, Maud, Demaurex, Nicolas

المصدر: ISSN: 0021-9258 ; The Journal of biological chemistry, vol. 286, no. 42 (2011) p. 36448-36459.

مصطلحات موضوعية: info:eu-repo/classification/ddc/612, Calcium/metabolism, Chelating Agents/pharmacology, Endoplasmic Reticulum/genetics/metabolism, Fluorescence Resonance Energy Transfer/methods, HeLa Cells, Humans, Membrane Proteins/genetics/metabolism, Neoplasm Proteins/genetics/metabolism, Protein Multimerization/drug effects/physiology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/21880734; https://archive-ouverte.unige.ch/unige:21499Test; unige:21499

الإتاحة: https://doi.org/10.1074/jbc.M111.269415Test
https://archive-ouverte.unige.ch/unige:21499Test