دورية أكاديمية
Role of VEGF Polymorphisms in the Susceptibility and Severity of Interstitial Lung Disease
| العنوان: | Role of VEGF Polymorphisms in the Susceptibility and Severity of Interstitial Lung Disease |
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| المؤلفون: | Remuzgo-Martínez, Sara, Genre, Fernanda, Pulito-Cueto, Verónica, Atienza-Mateo, Belén, Mora Cuesta, Víctor Manuel, Iturbe Fernández, David, Berastegui Garcia, Cristina |
| المساهمون: | Institut Català de la Salut, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | MDPI |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pulmons - Malalties - Aspectes genètics, Proteïnes quinases - Receptors, DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Interstitial, Other subheadings::Other subheadings::Other subheadings::/genetics, CHEMICALS AND DRUGS::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::Receptor Protein-Tyrosine Kinases::Receptors, Vascular Endothelial Growth Factor, ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares intersticiales, Otros calificadores::Otros calificadores::Otros calificadores::/genética, COMPUESTOS QUÍMICOS Y DROGAS::enzimas y coenzimas::enzimas::transferasas::fosfotransferasas::fosfotransferasas (grupo alcohol aceptor)::proteína cinasas::proteína-tirosina cinasas::receptores proteína-tirosina cinasas::receptores del factor de crecimiento del endotelio vascular |
| الوصف: | Biomarker; Interstitial lung disease; Vascular endothelial growth factor ; Biomarcador; Malaltia pulmonar intersticial; Factor de creixement endotelial vascular ; Biomarcador; Enfermedad pulmonar intersticial; Factor de crecimiento vascular endotelial ; The search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders. Consequently, we assessed, for the first time, the role of VEGF polymorphisms in the susceptibility and severity of ILD. A total of 436 Caucasian ILD patients (244 with idiopathic interstitial pneumonias (IIPs) and 192 with non-IIP) and 536 ethnically-matched healthy controls were genotyped for VEGF rs833061, rs1570360, rs2010963, rs3025020, and rs3025039 polymorphisms by TaqMan assays. Pulmonary function tests were collected from all the patients. VEGF serum levels were determined by ELISA in a subgroup of patients. No VEGF genotype, allele, carrier, or haplotype differences were found between ILD patients and controls as well as between IIP and non-IIP patients. However, an association of rs1570360 with IIP in women and also with lung function in IIP patients was found. None of the VEGF polymorphisms were associated with VEGF levels. In conclusion, our results suggest that VEGF does not seem to play a relevant role in ILD, although rs1570360 may influence the severity of ILD in women and a worse outcome in IIP patients. ; This research was partially supported by a grant from Spanish Society of Pulmonology and Thoracic Surgery (SEPAR 474-2017). S.R.-M. was supported by funds of the RETICS Program (RD16/0012/0009) from the “Instituto de Salud Carlos III” (ISCIII), co-funded by the European Regional Development Fund. V.P.-C. was supported by a pre-doctoral grant from IDIVAL (PREVAL 18/01). B.A.-M. was recipient of a “López Albo” post-residency program funded by Servicio Cántabro de Salud. L.L.-G. was supported by funds from IDIVAL ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2227-9059 |
| العلاقة: | Biomedicines;9; https://doi.org/10.3390/biomedicines9050458Test; info:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0012%2F0009; info:eu-repo/grantAgreement/ES/PE2013-2016/CP16%2F00033; Remuzgo-Martínez S, Genre F, Pulito-Cueto V, Atienza-Mateo B, Mora Cuesta VM, Iturbe Fernández D, et al. Role of VEGF Polymorphisms in the Susceptibility and Severity of Interstitial Lung Disease. Biomedicines. 2021 May;9:458.; https://hdl.handle.net/11351/6659Test; 000653399100001 |
| DOI: | 10.3390/biomedicines9050458 |
| الإتاحة: | https://doi.org/10.3390/biomedicines9050458Test https://hdl.handle.net/11351/6659Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.4A41D4E3 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22279059 |
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| DOI: | 10.3390/biomedicines9050458 |