دورية أكاديمية
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
| العنوان: | Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths |
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| المؤلفون: | Bastard P., Gervais A., Le Voyer T., Rosain J., Philippot Q., Manry J., Michailidis E., Hoffmann H. -H., Eto S., Garcia-Prat M., Bizien L., Parra-Martinez A., Yang R., Haljasmagi L., Migaud M., Sarekannu K., Maslovskaja J., Prost N. D., Tandjaoui-Lambiotte Y., Luyt C. -E., Amador-Borrero B., Gaudet A., Poissy J., Morel P., Richard P., Cognasse F., Troya J., Trouillet-Assant S., Belot A., Saker K., Garcon P., Riviere J. G., Lagier J. -C., Gentile S., Rosen L. B., Shaw E., Morio T., Tanaka J., Dalmau D., Tharaux P. -L., Sene D., Stepanian A., Megarbane B., Triantafyllia V., Fekkar A., Heath J. R., Franco J. L., Anaya J. -M., Sole-Violan J., Imberti L., Biondi A., Bonfanti P., Castagnoli R., Delmonte O. M., Zhang Y., Snow A. L., Holland S. M., Biggs C. M., Moncada-Velez M., Arias A. A., Lorenzo L., Boucherit S., Coulibaly B., Anglicheau D., Planas A. M., Haerynck F., Duvlis S., Nussbaum R. L., Ozcelik T., Keles S., Bousfiha A. A., Bakkouri J. E., Ramirez-Santana C., Paul S., Pan-Hammarstrom Q., Hammarstrom L., Dupont A., Kurolap A., Metz C. N., Aiuti A., Casari G., Lampasona V., Ciceri F., Barreiros L. A., Dominguez-Garrido E., Vidigal M., Zatz M., Beek D. V. D., Sahanic S., Tancevski I., Stepanovskyy Y., Boyarchuk O., Nukui Y., Tsumura M., Vidaur L., Tangye S. G., Burrel S., Duffy D., Quintana-Murci L., Klocperk A., Kann N. Y., Shcherbina A., Lau Y. -L., Leung D., Coulongeat M., Marlet J., Koning R., Reyes L. F., Chauvineau-Grenier A., Venet F., Monneret G., Nussenzweig M. C., Arrestier R., Boudhabhay I., Baris-Feldman H., Hagin D., Wauters J., Meyts I., Dyer A. H., Kennelly S. P., Bourke N. M., Halwani R., Sharif-Askari N. S., Dorgham K., Sallette J., Sedkaoui S. M., AlKhater S., Rigo-Bonnin R., Morandeira F., Roussel L., Vinh D. C., Ostrowski S. R., Condino-Neto A., Prando C., Bondarenko A., Spaan A. N., Gilardin L., Fellay J., Lyonnet S., Bilguvar K., Lifton R. P., Mane S., Anderson M. S., Boisson B., Beziat V., Zhang S. -Y., Andreakos E., Hermine O., Pujol A., Peterson P., Mogensen T. H., Rowen L., Mond J., Debette S., Lamballerie X. D., Duval X., Mentre F., Zins M., Soler-Palacin P., Colobran R., Gorochov G., Solanich X., Susen S., Martinez-Picado J., Raoult D., Vasse M., Gregersen P. K., Piemonti L., Rodriguez-Gallego C., Notarangelo L. D., Su H. C., Kisand K., Okada S., Puel A., Jouanguy E., Rice C. M., Tiberghien P., Zhang Q., Cobat A., Abel L., Casanova J. -L. |
| المساهمون: | Bastard, P., Gervais, A., Le Voyer, T., Rosain, J., Philippot, Q., Manry, J., Michailidis, E., Hoffmann, H. -H., Eto, S., Garcia-Prat, M., Bizien, L., Parra-Martinez, A., Yang, R., Haljasmagi, L., Migaud, M., Sarekannu, K., Maslovskaja, J., Prost, N. D., Tandjaoui-Lambiotte, Y., Luyt, C. -E., Amador-Borrero, B., Gaudet, A., Poissy, J., Morel, P., Richard, P., Cognasse, F., Troya, J., Trouillet-Assant, S., Belot, A., Saker, K., Garcon, P., Riviere, J. G., Lagier, J. -C., Gentile, S., Rosen, L. B., Shaw, E., Morio, T., Tanaka, J., Dalmau, D., Tharaux, P. -L., Sene, D., Stepanian, A., Megarbane, B., Triantafyllia, V., Fekkar, A., Heath, J. R., Franco, J. L., Anaya, J. -M., Sole-Violan, J., Imberti, L., Biondi, A., Bonfanti, P., Castagnoli, R., Delmonte, O. M., Zhang, Y., Snow, A. L., Holland, S. M., Biggs, C. M., Moncada-Velez, M., Arias, A. A., Lorenzo, L., Boucherit, S., Coulibaly, B., Anglicheau, D., Planas, A. M., Haerynck, F., Duvlis, S., Nussbaum, R. L., Ozcelik, T., Keles, S., Bousfiha, A. A., Bakkouri, J. E., Ramirez-Santana, C., Paul, S., Pan-Hammarstrom, Q., Hammarstrom, L., Dupont, A., Kurolap, A., Metz, C. N., Aiuti, A., Casari, G., Lampasona, V., Ciceri, F., Barreiros, L. A., Dominguez-Garrido, E., Vidigal, M., Zatz, M., Beek, D. V. D., Sahanic, S., Tancevski, I., Stepanovskyy, Y., Boyarchuk, O., Nukui, Y., Tsumura, M., Vidaur, L., Tangye, S. G., Burrel, S., Duffy, D., Quintana-Murci, L., Klocperk, A. |
| سنة النشر: | 2021 |
| المجموعة: | IRIS UNIPV (Università degli studi di Pavia) |
| مصطلحات موضوعية: | Adolescent, Adult, Aged, 80 and over, Antibodies, Neutralizing, Autoantibodie, COVID-19, Case-Control Studie, Child, Preschool, Critical Illne, Human, Immunoglobulin G, Infant, Newborn, Interferon Type I, Interferon-alpha, Middle Aged, Young Adult |
| الوصف: | Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or IFN-ω (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or IFN-ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34413139; info:eu-repo/semantics/altIdentifier/wos/WOS:000695969700002; volume:6; issue:62; journal:SCIENCE IMMUNOLOGY; http://hdl.handle.net/11571/1446839Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85113517428 |
| DOI: | 10.1126/sciimmunol.abl4340 |
| الإتاحة: | https://doi.org/10.1126/sciimmunol.abl4340Test http://hdl.handle.net/11571/1446839Test |
| رقم الانضمام: | edsbas.AE4B4BFC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1126/sciimmunol.abl4340 |
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