المؤلفون: Beumer, Joep, Bauzá-Martinez, Julia, Veth, Tim S., Geurts, Veerle, Boot, Charelle, Gilliam-Vigh, Hannah, Poulsen, Steen S., Knop, Filip K., Wu, Wei, Clevers, Hans

المساهمون: Hubrecht Institute with UMC, CMM, Cancer

مصطلحات موضوعية: CRISPR-Cas9, enteroendocrine cells, intestinal organoids, peptidomics, prohormone processing, General

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/447917Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/447917Test

المؤلفون: Sofia Ferreira, Ana F. Raimundo, Inês Farrim, Regina Menezes

المصدر: Journal Biomedical and Biopharmaceutical Research (BBR), Vol 19, Iss 2, Pp 337-354 (2022)

مصطلحات موضوعية: amilina, polipéptido, amilóide dos ilhéus (iapp), kexina 2, processamento de pro-hormonas, saccharomyces cerevisiae, amylin, islet amyloid polypeptide (iapp), kexin 2, prohormone processing, Therapeutics. Pharmacology, RM1-950

العلاقة: https://www.alies.pt/BBR%20Editions/Vol-19-2-2022/bbr.19.2.301.pdfTest; https://doaj.org/toc/2182-2379Test; https://doaj.org/article/a9b85f4c8254466db275361cd8fd418fTest

الإتاحة: https://doi.org/10.19277/bbr.19.2.301Test
https://doaj.org/article/a9b85f4c8254466db275361cd8fd418fTest

المؤلفون: Park, Chung‐Mo, Bruenn, Jeremy A., Ganesa, Chandrashekar, Flurkey, William F., Bozarth, Robert F., Koltin, Yigal

المساهمون: Park, Chung‐Mo

مصطلحات موضوعية: DOUBLE-STRANDED-RNA, PROHORMONE-PROCESSING ENZYME, KILLER TOXIN, SACCHAROMYCES-CEREVISIAE, MAMMALIAN-CELLS, GENE ENCODES, ALPHA-FACTOR, YEAST, PROTEASE, VIRUS

العلاقة: Molecular Microbiology, Vol.11 No.1, pp.155-164; https://hdl.handle.net/10371/190010Test; A1994MQ20600016; 2-s2.0-0028306740; 147992

الإتاحة: https://doi.org/10.1111/j.1365-2958.1994.tb00297.xTest
https://hdl.handle.net/10371/190010Test

المؤلفون: Sam G. Galvin (11313930), Richard G. Kay (2327857), Rachel Foreman (11313933), Pierre Larraufie (6067598), Claire L. Meek (7242761), Emma Biggs (11313936), Peter Ravn (494111), Lutz Jermutus (608646), Frank Reimann (707211), Fiona M. Gribble (7242782)

مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Physiology, Biotechnology, Immunology, Developmental Biology, Virology, Chemical Sciences not elsewhere classified, mouse pancreatic islets, GIP, Type 2 Diabetes, islet insulin production, Glucose-dependent insulinotropic pe., Mouse Islet Peptidome, GLP, mouse islet incubations, LC-MS, prohormone processing defects, mouse islets

العلاقة: https://figshare.com/articles/journal_contribution/The_Human_and_Mouse_Islet_Peptidome_Effects_of_Obesity_and_Type_2_Diabetes_and_Assessment_of_Intraislet_Production_of_Glucagon-like_Peptide_1/16411344Test

الإتاحة: https://doi.org/10.1021/acs.jproteome.1c00463.s001Test

المؤلفون: Greenwood, Mingkwan, Paterson, Alex, Rahman, Parveen Akhter, Gillard, Benjamin Thomas, Langley, Sydney, Iwasaki, Yasumasa, Murphy, David, Greenwood, Michael Paul

المصدر: Greenwood , M , Paterson , A , Rahman , P A , Gillard , B T , Langley , S , Iwasaki , Y , Murphy , D & Greenwood , M P 2020 , ' Transcription factor Creb3l1 regulates the synthesis of prohormone convertase enzyme PC1/3 in endocrine cells ' , Journal of Neuroendocrinology , vol. 32 , no. 4 , E12851 . https://doi.org/10.1111/jne.12851Test

مصطلحات موضوعية: dehydration, pituitary, POMC, prohormone processing, supraoptic nucleus, transcription

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1111/jne.12851Test
https://hdl.handle.net/1983/10d28188-9854-4542-aa2c-c357349af22dTest
https://research-information.bris.ac.uk/en/publications/10d28188-9854-4542-aa2c-c357349af22dTest
https://research-information.bris.ac.uk/ws/files/233004749/jne.12851.pdfTest

المؤلفون: Joep Beumer, Julia Bauzá-Martinez, Tim S. Veth, Veerle Geurts, Charelle Boot, Hannah Gilliam-Vigh, Steen S. Poulsen, Filip K. Knop, Wei Wu, Hans Clevers

المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research

المصدر: Beumer, J, Bauzá-Martinez, J, Veth, T S, Geurts, V, Boot, C, Gilliam-Vigh, H, Poulsen, S S, Knop, F K, Wu, W & Clevers, H 2022, ' Mapping prohormone processing by proteases in human enteroendocrine cells using genetically engineered organoid models ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 46, e2212057119 . https://doi.org/10.1073/pnas.2212057119Test
Proceedings of the National Academy of Sciences of the United States of America, 119(46). National Academy of Sciences

مصطلحات موضوعية: Multidisciplinary, enteroendocrine cells, Insulin/metabolism, Enteroendocrine Cells, peptidomics, Peptide Hydrolases/genetics, prohormone processing, Enteroendocrine Cells/metabolism, Organoids, intestinal organoids, Endopeptidases/metabolism, Endopeptidases, Humans, Insulin, CRISPR-Cas9, Peptide Hydrolases

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266b5fb4e15516660a7b245ba371ce25Test
https://pubmed.ncbi.nlm.nih.gov/36343264Test

المؤلفون: J. Peter H. Burbach, Philip Grant, Anita J. C. G. M. Hellemons, Joseph A. Degiorgis, Ka Wan Li, Harish C. Pant

المصدر: Biology Open, Vol 3, Iss 1, Pp 50-58 (2013)

مصطلحات موضوعية: FMRFamide, Cephalopods, Mollusk, Stellate ganglion, Giant axon, Prohormone processing, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: http://bio.biologists.org/content/3/1/50Test; https://doaj.org/toc/2046-6390Test

الوصول الحر: https://doaj.org/article/69f3acfbe5f74259880abc412250695cTest

المؤلفون: Michael eWeiss, Shu-Jin eChan

المصدر: Frontiers in Endocrinology, Vol 6 (2015)

مصطلحات موضوعية: Diabetes Mellitus, Proinsulin, Insulin receptor, Prohormone processing, hormone biosynthesis, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

العلاقة: http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00057/fullTest; https://doaj.org/toc/1664-2392Test

الوصول الحر: https://doaj.org/article/3ae53b5d285a4ef6a805ccf7661215edTest

المؤلفون: Ouafik, L'Houcine, Giraud, Pierre, Salers, Paul, Dutour, Anne, Castanas, Elias, Boudouresque, Françoise, Oliver, Charles

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 1987 Jan 01. 84(1), 261-264.

الوصول الحر: https://www.jstor.org/stable/28989Test

المؤلفون: Mezey, Eva, Fricker, Lloyd D., Pruss, Rebecca M., Siegel, Ruth E., Brownstein, Michael J.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 1985 Jul . 82(14), 4745-4749.

الوصول الحر: https://www.jstor.org/stable/26121Test